HIPHOP chemogenomics database

YML068W / ITT1

Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins

Zygosity: Homozygous strain

fixedexpanded
Profile for YML068W / ITT1

Click on Significant Values for Screen Details

Top fitness defect scores for YML068W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_814	3342-0569	7.01	96.0 µM	2.89E-15		1	1.23E-12
2	SGTC_815	1582-0027	5.84	36.9 µM	3.78E-11		2	2.63E-9
3	SGTC_2843	9000894	5.78	45.5 µM	5.99E-11		1	3.83E-9
4	SGTC_3065	9113888	5.61	49.5 µM	2.04E-10		6	1.03E-8
5	SGTC_1583	clindamycin	4.93	39.6 µM	1.93E-8	mitochondrial processes	3	4.11E-7
6	SGTC_2565	isoliquiritigenin	4.85	100.0 µM	3.25E-8		19	6.28E-7
7	SGTC_1701	st028638	4.34	40.4 µM	6.34E-7		10	7.00E-6
8	SGTC_631	k072-0230	4.30	41.5 µM	7.90E-7	60S ribosome export	13	8.37E-6
9	SGTC_2126	5251174	4.23	33.9 µM	1.18E-6		22	1.16E-5
10	SGTC_3332	9141069	4.21	11.2 µM	1.31E-6		10	1.26E-5
11	SGTC_2845	9003024	3.91	43.0 µM	6.55E-6	amide catabolism	46	4.67E-5
12	SGTC_3217	9129673	3.89	49.5 µM	7.21E-6		42	5.04E-5
13	SGTC_965	1291-5240	3.84	308.0 µM	9.38E-6		32	6.25E-5
14	SGTC_1412	3909-8563	3.70	178.0 µM	1.84E-5		12	1.08E-4
15	SGTC_2131	toluylene red	3.67	5.3 µM	2.16E-5	60S ribosome export	30	1.23E-4
16	SGTC_1797	st048695	3.58	56.8 µM	3.28E-5	NEO1	82	1.73E-4
17	SGTC_3214	9129694	3.44	49.5 µM	6.24E-5		39	2.92E-4
18	SGTC_3205	9113483	3.38	49.5 µM	8.25E-5		57	3.67E-4
19	SGTC_2245	6637752	3.21	200.0 µM	1.72E-4		32	6.68E-4
20	SGTC_632	0781-2353	3.10	4.7 µM	2.72E-4	Golgi	84	9.71E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.126	2.07E-13	YEL001C	IRC22	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.114	3.29E-11	YBR085C-A	YBR085C-A	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.104	1.31E-9	YNL094W	APP1	hom	Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.102	2.94E-9	YGR210C_p	YGR210C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.100	6.27E-9	YER181C_d	YER181C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
0.096	2.21E-8	YKL202W_d	YKL202W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096	2.31E-8	YDR436W	PPZ2	hom	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.095	4.10E-8	YMR088C	VBA1	hom	Permease of basic amino acids in the vacuolar membrane
0.094	5.02E-8	YIL146C	ATG32	hom	Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.094	5.67E-8	YKL006C-A	SFT1	het	Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment
0.090	1.70E-7	YDR400W	URH1	hom	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.089	2.30E-7	YLR307C-A_p	YLR307C-A_p	hom	Putative protein of unknown function
0.084	9.82E-7	YLR054C	OSW2	hom	Protein of unknown function proposed to be involved in the assembly of the spore wall
0.083	1.66E-6	YER067W	RGI1	hom	Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
0.082	1.76E-6	YGR292W	MAL12	hom	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose