YML070W / DAK1

Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

Zygosity: Homozygous strain
fixedexpanded
Profile for YML070W / DAK1

Click on Significant Values for Screen Details ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.66|P-value:8.58E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.65|P-value:8.26E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.34|P-value:1.45E-10 ID:SGTC_732|Compound:3970-1727|FD-Score:2.69|P-value:6.92E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.68|P-value:8.03E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.26|P-value:6.10E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:2.92|P-value:2.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.73|P-value:6.54E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.17|P-value:9.61E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.93|P-value:2.46E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.27|P-value:5.15E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:2.95|P-value:2.30E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.74|P-value:5.53E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-2.99|P-value:2.16E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.58|P-value:1.23E-5 ID:SGTC_1783|Compound:st039459|FD-Score:2.77|P-value:5.06E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.71|P-value:7.10E-4 ID:SGTC_1980|Compound:st071811|FD-Score:2.66|P-value:7.96E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-2.93|P-value:2.82E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.83|P-value:3.85E-4 ID:SGTC_2069|Compound:5228469|FD-Score:5.31|P-value:1.50E-10 ID:SGTC_2304|Compound:7443016|FD-Score:-2.80|P-value:4.98E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.07|P-value:1.47E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.87|P-value:3.22E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.61|P-value:9.23E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-2.73|P-value:6.67E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.37|P-value:3.18E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.23|P-value:6.17E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.80|P-value:3.84E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:2.77|P-value:4.98E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.91|P-value:2.68E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.23|P-value:7.17E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.39|P-value:2.91E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-2.69|P-value:7.58E-4 ID:SGTC_2707|Compound:st078556|FD-Score:2.80|P-value:4.34E-4 ID:SGTC_2717|Compound:st081029|FD-Score:2.77|P-value:4.98E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.38|P-value:1.19E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.72|P-value:1.33E-8 ID:SGTC_2794|Compound:7785382|FD-Score:4.33|P-value:1.39E-7 ID:SGTC_2799|Compound:7812892|FD-Score:3.82|P-value:2.85E-6 ID:SGTC_2803|Compound:7707263|FD-Score:4.33|P-value:1.42E-7 ID:SGTC_2850|Compound:9015429|FD-Score:-2.66|P-value:8.57E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.53|P-value:1.37E-5 ID:SGTC_3342|Compound:9147791|FD-Score:2.75|P-value:5.34E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.66|P-value:8.58E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:-3.65|P-value:8.26E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-5.34|P-value:1.45E-10 ID:SGTC_732|Compound:3970-1727|FD-Score:2.69|P-value:6.92E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.68|P-value:8.03E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.26|P-value:6.10E-5 ID:SGTC_934|Compound:2950-0684|FD-Score:2.92|P-value:2.59E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-2.73|P-value:6.54E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.17|P-value:9.61E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:2.93|P-value:2.46E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.27|P-value:5.15E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:2.95|P-value:2.30E-4 ID:SGTC_1606|Compound:st000094|FD-Score:2.74|P-value:5.53E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-2.99|P-value:2.16E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-3.58|P-value:1.23E-5 ID:SGTC_1783|Compound:st039459|FD-Score:2.77|P-value:5.06E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.71|P-value:7.10E-4 ID:SGTC_1980|Compound:st071811|FD-Score:2.66|P-value:7.96E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-2.93|P-value:2.82E-4 ID:SGTC_1996|Compound:st072960|FD-Score:2.83|P-value:3.85E-4 ID:SGTC_2069|Compound:5228469|FD-Score:5.31|P-value:1.50E-10 ID:SGTC_2304|Compound:7443016|FD-Score:-2.80|P-value:4.98E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-3.07|P-value:1.47E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:2.87|P-value:3.22E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.61|P-value:9.23E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-2.73|P-value:6.67E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.37|P-value:3.18E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.23|P-value:6.17E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.80|P-value:3.84E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:2.77|P-value:4.98E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.91|P-value:2.68E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.23|P-value:7.17E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.39|P-value:2.91E-5 ID:SGTC_2706|Compound:st078239|FD-Score:-2.69|P-value:7.58E-4 ID:SGTC_2707|Compound:st078556|FD-Score:2.80|P-value:4.34E-4 ID:SGTC_2717|Compound:st081029|FD-Score:2.77|P-value:4.98E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:-4.38|P-value:1.19E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.72|P-value:1.33E-8 ID:SGTC_2794|Compound:7785382|FD-Score:4.33|P-value:1.39E-7 ID:SGTC_2799|Compound:7812892|FD-Score:3.82|P-value:2.85E-6 ID:SGTC_2803|Compound:7707263|FD-Score:4.33|P-value:1.42E-7 ID:SGTC_2850|Compound:9015429|FD-Score:-2.66|P-value:8.57E-4 ID:SGTC_3336|Compound:9143619|FD-Score:3.53|P-value:1.37E-5 ID:SGTC_3342|Compound:9147791|FD-Score:2.75|P-value:5.34E-4

Top fitness defect scores for YML070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2069 5228469 5.31 200.0 µM 1.50E-10 3 5.44E-8
2 SGTC_2794 7785382 4.33 27.3 µM 1.39E-7 22 7.45E-6
3 SGTC_2803 7707263 4.33 71.4 µM 1.42E-7 24 7.59E-6
4 SGTC_2799 7812892 3.82 81.8 µM 2.85E-6 superoxide 34 6.61E-5
5 SGTC_2421 5690543 3.61 90.7 µM 9.23E-6 27 1.55E-4
6 SGTC_3336 9143619 3.53 71.4 µM 1.37E-5 29 2.06E-4
7 SGTC_2608 thymoquinone 3.39 42.7 µM 2.91E-5 33 3.56E-4
8 SGTC_2430 5571206 3.37 200.0 µM 3.18E-5 82 3.80E-4
9 SGTC_1248 0469-0687 3.27 58.6 µM 5.15E-5 60 5.38E-4
10 SGTC_2435 5706476 3.23 10.6 µM 6.17E-5 51 6.14E-4
11 SGTC_1570 verbenone 2.95 133.0 µM 2.30E-4 57 0.00160
12 SGTC_1172 0370-0043 2.93 85.0 µM 2.46E-4 68 0.00168
13 SGTC_934 2950-0684 2.92 338.0 µM 2.59E-4 67 0.00174
14 SGTC_2605 digitonin 2.91 300.0 nM 2.68E-4 92 0.00179
15 SGTC_2407 paclitaxel 2.87 400.0 µM 3.22E-4 95 0.00205
16 SGTC_1996 st072960 2.83 66.8 µM 3.85E-4 64 0.00233
17 SGTC_2707 st078556 2.80 66.6 µM 4.34E-4 51 0.00254
18 SGTC_2717 st081029 2.77 62.3 µM 4.98E-4 53 0.00281
19 SGTC_2584 androsterone 2.77 48.7 µM 4.98E-4 cell wall 242 0.00281
20 SGTC_1783 st039459 2.77 87.5 µM 5.06E-4 Golgi 92 0.00284

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.20E-25 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.167 2.34E-22 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.150 2.92E-18 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.143 7.32E-17 YBR153W RIB7 het Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
0.142 1.24E-16 YLR259C HSP60 het Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
0.129 7.10E-14 YMR133W REC114 hom Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
0.125 3.63E-13 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.114 3.40E-11 YOR289W_p YOR289W_p hom Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.113 5.18E-11 YLR410W VIP1 hom Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1
0.113 5.63E-11 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.111 1.18E-10 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.110 1.62E-10 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication
0.108 3.16E-10 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.108 3.26E-10 YBL039W-B_p YBL039W-B_p hom Putative protein of unknown function
0.105 9.77E-10 YDL103C QRI1 het UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress