YML073C / RPL6A

Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML073C / RPL6A

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.60|P-value:3.14E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.57|P-value:3.54E-10 ID:SGTC_75|Compound:0159-0059|FD-Score:3.37|P-value:6.79E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.30|P-value:8.39E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.25|P-value:9.73E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.03|P-value:6.67E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.21|P-value:4.72E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:8.90|P-value:4.93E-17 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.36|P-value:1.90E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.62|P-value:1.59E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.30|P-value:8.24E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.48|P-value:2.69E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.21|P-value:7.60E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.26|P-value:9.41E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.43|P-value:1.43E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.00|P-value:2.74E-11 ID:SGTC_543|Compound:3844-1095|FD-Score:5.72|P-value:3.88E-8 ID:SGTC_562|Compound:3772-2733|FD-Score:5.13|P-value:6.78E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.71|P-value:4.41E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.87|P-value:5.53E-6 ID:SGTC_1182|Compound:1222-0449|FD-Score:6.95|P-value:3.77E-11 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.84|P-value:2.86E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-4.07|P-value:1.27E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.53|P-value:1.57E-9 ID:SGTC_1916|Compound:st067606|FD-Score:3.44|P-value:5.25E-4 ID:SGTC_1938|Compound:st074717|FD-Score:5.99|P-value:9.05E-9 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.83|P-value:3.01E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.61|P-value:3.03E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.09|P-value:1.18E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.50|P-value:2.52E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.86|P-value:6.39E-11 ID:SGTC_2484|Compound:5809818|FD-Score:-3.63|P-value:5.75E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.58|P-value:6.86E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.97|P-value:1.81E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.60|P-value:6.42E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.38|P-value:2.07E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.37|P-value:6.58E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.47|P-value:1.22E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.47|P-value:9.64E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.63|P-value:5.68E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.50|P-value:8.75E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.14|P-value:9.96E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-5.20|P-value:1.31E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.75|P-value:3.93E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.69|P-value:1.16E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:3.60|P-value:3.14E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:6.57|P-value:3.54E-10 ID:SGTC_75|Compound:0159-0059|FD-Score:3.37|P-value:6.79E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.30|P-value:8.39E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:3.25|P-value:9.73E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.03|P-value:6.67E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:5.21|P-value:4.72E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:8.90|P-value:4.93E-17 ID:SGTC_246|Compound:cycloheximide|FD-Score:4.36|P-value:1.90E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.62|P-value:1.59E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.30|P-value:8.24E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:-4.48|P-value:2.69E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.21|P-value:7.60E-5 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.26|P-value:9.41E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.43|P-value:1.43E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:7.00|P-value:2.74E-11 ID:SGTC_543|Compound:3844-1095|FD-Score:5.72|P-value:3.88E-8 ID:SGTC_562|Compound:3772-2733|FD-Score:5.13|P-value:6.78E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:4.71|P-value:4.41E-6 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-4.87|P-value:5.53E-6 ID:SGTC_1182|Compound:1222-0449|FD-Score:6.95|P-value:3.77E-11 ID:SGTC_1184|Compound:1269-1718|FD-Score:-3.84|P-value:2.86E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-4.07|P-value:1.27E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.53|P-value:1.57E-9 ID:SGTC_1916|Compound:st067606|FD-Score:3.44|P-value:5.25E-4 ID:SGTC_1938|Compound:st074717|FD-Score:5.99|P-value:9.05E-9 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:-3.83|P-value:3.01E-4 ID:SGTC_2181|Compound:6316240|FD-Score:3.61|P-value:3.03E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-4.09|P-value:1.18E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-4.50|P-value:2.52E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.86|P-value:6.39E-11 ID:SGTC_2484|Compound:5809818|FD-Score:-3.63|P-value:5.75E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.58|P-value:6.86E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-3.97|P-value:1.81E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.75|P-value:1.89E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.60|P-value:6.42E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.38|P-value:2.07E-7 ID:SGTC_2808|Compound:7946468|FD-Score:3.37|P-value:6.58E-4 ID:SGTC_2853|Compound:9015042|FD-Score:4.47|P-value:1.22E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.47|P-value:9.64E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-3.63|P-value:5.68E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.50|P-value:8.75E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.14|P-value:9.96E-5 ID:SGTC_2952|Compound:9073731|FD-Score:-5.20|P-value:1.31E-6 ID:SGTC_3037|Compound:9091026|FD-Score:-3.75|P-value:3.93E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-4.69|P-value:1.16E-5

Top fitness defect scores for YML073C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_168 3970-0862 8.90 530.5 µM 4.93E-17 16 2.87E-19
2 SGTC_528 3492-0019 7.00 172.0 µM 2.74E-11 calcium & mitochondrial duress 94 1.27E-12
3 SGTC_1182 1222-0449 6.95 220.0 µM 3.77E-11 1 1.84E-12
4 SGTC_2405 ticlatone 6.86 3.5 µM 6.39E-11 19 3.38E-12
5 SGTC_70 0141-0289 6.57 43.3 µM 3.54E-10 mitochondrial stress 63 2.44E-11
6 SGTC_1938 st074717 5.99 56.4 µM 9.05E-9 3 1.02E-9
7 SGTC_543 3844-1095 5.72 191.0 µM 3.88E-8 ERG2 20 5.43E-9
8 SGTC_2688 kanamycin b 5.38 96.7 µM 2.07E-7 calcium & mitochondrial duress 205 3.72E-8
9 SGTC_118 0083-0097 5.21 135.3 µM 4.72E-7 translation 47 9.58E-8
10 SGTC_562 3772-2733 5.13 112.0 µM 6.78E-7 ERG2 48 1.45E-7
11 SGTC_800 3448-7362 4.71 155.0 µM 4.41E-6 translation 103 1.24E-6
12 SGTC_2853 9015042 4.47 58.4 µM 1.22E-5 17 3.94E-6
13 SGTC_488 nitrendipine 4.43 139.0 µM 1.43E-5 34 4.73E-6
14 SGTC_246 cycloheximide 4.36 667.0 µM 1.90E-5 9 6.56E-6
15 SGTC_115 0527-0192 4.03 112.0 µM 6.67E-5 63 2.75E-5
16 SGTC_2651 1327-0036 3.75 5.0 µM 1.89E-4 178 8.97E-5
17 SGTC_2181 6316240 3.61 54.3 µM 3.03E-4 30 1.53E-4
18 SGTC_26 0302-0163 3.60 425.2 µM 3.14E-4 heme biosynthesis & mitochondrial translocase 14 1.60E-4
19 SGTC_1916 st067606 3.44 49.2 µM 5.25E-4 64 2.86E-4
20 SGTC_2808 7946468 3.37 45.5 µM 6.58E-4 49 3.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 4.14E-30 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
0.195 4.47E-30 YBR267W REI1 hom Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
0.194 1.02E-29 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.194 1.26E-29 YJL101C GSH1 hom Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress
0.178 2.41E-25 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.178 2.97E-25 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.178 3.82E-25 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.173 6.81E-24 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.172 1.45E-23 YJL189W RPL39 hom Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog
0.170 5.34E-23 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.165 8.31E-22 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.163 2.19E-21 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.160 1.15E-20 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.159 2.10E-20 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.159 1.97E-20 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data