YML074C / FPR3

Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YML074C / FPR3

Click on Significant Values for Screen Details ID:SGTC_310|Compound:1273-0058|FD-Score:3.82|P-value:2.37E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.15|P-value:3.97E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.11|P-value:6.31E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.08|P-value:6.48E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.67|P-value:4.87E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.21|P-value:5.31E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.88|P-value:3.45E-10 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.64|P-value:4.10E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:-5.02|P-value:7.19E-8 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.03|P-value:6.24E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.46|P-value:1.15E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.93|P-value:8.90E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.90|P-value:9.85E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.05|P-value:5.64E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.87|P-value:1.89E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.98|P-value:9.39E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.36|P-value:1.69E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-2.99|P-value:8.99E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.59|P-value:6.48E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.96|P-value:7.81E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.64|P-value:7.21E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.74|P-value:3.52E-7 ID:SGTC_2987|Compound:9018338|FD-Score:-3.45|P-value:1.53E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.46|P-value:1.47E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:3.82|P-value:2.37E-5 ID:SGTC_349|Compound:k015-0014|FD-Score:3.45|P-value:1.21E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.15|P-value:3.97E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.11|P-value:6.31E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:-3.08|P-value:6.48E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.67|P-value:4.87E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.21|P-value:5.31E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.88|P-value:3.45E-10 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.43|P-value:1.30E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:4.64|P-value:4.10E-7 ID:SGTC_1128|Compound:3448-9350|FD-Score:-5.02|P-value:7.19E-8 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.03|P-value:6.24E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.46|P-value:1.15E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:2.93|P-value:8.90E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:2.90|P-value:9.85E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.05|P-value:5.64E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.87|P-value:1.89E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.98|P-value:9.39E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.36|P-value:1.69E-4 ID:SGTC_2515|Compound:chrysin|FD-Score:-2.99|P-value:8.99E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.59|P-value:6.48E-5 ID:SGTC_2722|Compound:naftopidil|FD-Score:2.96|P-value:7.81E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.64|P-value:7.21E-5 ID:SGTC_2971|Compound:9092186|FD-Score:-4.74|P-value:3.52E-7 ID:SGTC_2987|Compound:9018338|FD-Score:-3.45|P-value:1.53E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.46|P-value:1.47E-4

Top fitness defect scores for YML074C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1125 tnp00248 4.64 1.3 µM 4.10E-7 16 1.74E-6
2 SGTC_545 4218-0007 4.11 221.0 µM 6.31E-6 25 2.02E-5
3 SGTC_2103 5378138 3.87 10.0 µM 1.89E-5 18 5.39E-5
4 SGTC_310 1273-0058 3.82 1.1 µM 2.37E-5 mitochondrial stress 253 6.61E-5
5 SGTC_2704 st078022 3.59 71.1 µM 6.48E-5 20 1.63E-4
6 SGTC_1311 1190-0148 3.46 100.0 µM 1.15E-4 azole & statin 41 2.71E-4
7 SGTC_349 k015-0014 3.45 24.0 µM 1.21E-4 39 2.84E-4
8 SGTC_1121 fusaric acid 3.43 630.5 nM 1.30E-4 53 3.05E-4
9 SGTC_2514 salinomycin 3.36 42.7 µM 1.69E-4 82 3.85E-4
10 SGTC_360 0957-0399 3.15 1.0 µM 3.97E-4 cell wall 87 8.26E-4
11 SGTC_1587 estradiol valerate 3.05 56.1 µM 5.64E-4 41 0.00113
12 SGTC_1222 0366-0074 3.03 1.2 µM 6.24E-4 TSC3-RPN4 52 0.00124
13 SGTC_2722 naftopidil 2.96 47.2 µM 7.81E-4 43 0.00152
14 SGTC_1344 1488-0097 2.93 29.1 µM 8.90E-4 57 0.00170
15 SGTC_1376 2910-0861 2.90 41.3 µM 9.85E-4 81 0.00187
16 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 2.89 3.7 µM 0.00102 227 0.00192
17 SGTC_350 k064-0020 2.89 19.8 µM 0.00102 heme requiring 79 0.00192
18 SGTC_1890 3',4',7',8'-tetrahydroxyflavone 2.87 14.9 µM 0.00110 52 0.00206
19 SGTC_1333 1482-0047 2.87 286.0 µM 0.00111 73 0.00207
20 SGTC_371 0195-0006 2.87 7.4 µM 0.00111 70 0.00208

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.295 1.91E-68 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.295 2.93E-68 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.249 1.02E-48 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.227 1.40E-40 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.224 1.77E-39 YBR090C_p YBR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.213 9.37E-36 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.199 2.28E-31 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.192 4.23E-29 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.191 5.65E-29 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.183 8.72E-27 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.183 1.40E-26 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.181 4.86E-26 YJR127C RSF2 hom Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.176 8.46E-25 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.173 6.89E-24 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.170 4.78E-23 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion