YML075C / HMG1

HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YML075C / HMG1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:8.10|P-value:2.14E-16 ID:SGTC_216|Compound:k038-0035|FD-Score:3.24|P-value:5.82E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:30.20|P-value:1.04E-201 ID:SGTC_252|Compound:miconazole|FD-Score:6.10|P-value:4.50E-10 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.27|P-value:5.06E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.12|P-value:4.14E-10 ID:SGTC_279|Compound:1273-0055|FD-Score:8.66|P-value:1.83E-18 ID:SGTC_294|Compound:k038-0071|FD-Score:9.32|P-value:4.30E-21 ID:SGTC_299|Compound:1273-0059|FD-Score:4.60|P-value:1.95E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.15|P-value:7.75E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.67|P-value:1.36E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:3.36|P-value:3.76E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:6.48|P-value:3.86E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:3.80|P-value:6.94E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.32|P-value:4.25E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.56|P-value:1.74E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.36|P-value:3.74E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.13|P-value:8.51E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.73|P-value:1.01E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:8.93|P-value:1.62E-19 ID:SGTC_601|Compound:0986-0029|FD-Score:4.35|P-value:6.39E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:4.08|P-value:2.08E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.74|P-value:8.85E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:10.20|P-value:4.89E-25 ID:SGTC_794|Compound:k038-0031|FD-Score:5.40|P-value:2.99E-8 ID:SGTC_862|Compound:0452-0056|FD-Score:8.58|P-value:3.70E-18 ID:SGTC_871|Compound:0574-0004|FD-Score:8.81|P-value:4.63E-19 ID:SGTC_940|Compound:3232-1287|FD-Score:3.30|P-value:4.61E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.18|P-value:7.05E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.92|P-value:4.14E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.16|P-value:3.07E-10 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.56|P-value:1.16E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.15|P-value:1.40E-16 ID:SGTC_1086|Compound:cerivastatin|FD-Score:7.51|P-value:2.46E-14 ID:SGTC_1097|Compound:itavastatin|FD-Score:20.40|P-value:1.74E-93 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.49|P-value:2.26E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.95|P-value:1.18E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.81|P-value:6.42E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:9.96|P-value:7.96E-24 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.64|P-value:7.57E-9 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.31|P-value:4.38E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.77|P-value:8.31E-7 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.31|P-value:4.53E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:5.44|P-value:2.31E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.62|P-value:1.38E-4 ID:SGTC_1521|Compound:st012942|FD-Score:5.34|P-value:4.08E-8 ID:SGTC_1524|Compound:corynanthine|FD-Score:8.35|P-value:2.71E-17 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.26|P-value:5.41E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.61|P-value:1.89E-6 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:6.11|P-value:4.24E-10 ID:SGTC_1745|Compound:st081495|FD-Score:4.94|P-value:3.60E-7 ID:SGTC_1750|Compound:st081859|FD-Score:-7.05|P-value:7.15E-13 ID:SGTC_1780|Compound:st038448|FD-Score:-3.65|P-value:1.22E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.08|P-value:9.95E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.16|P-value:1.47E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:25.60|P-value:9.31E-146 ID:SGTC_1800|Compound:st050079|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.81|P-value:6.87E-7 ID:SGTC_1834|Compound:st055981|FD-Score:-3.83|P-value:6.15E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-4.64|P-value:1.62E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.43|P-value:5.37E-11 ID:SGTC_1848|Compound:st056003|FD-Score:-3.18|P-value:6.96E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.15|P-value:7.95E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-4.23|P-value:1.09E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.08|P-value:9.88E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.30|P-value:4.63E-4 ID:SGTC_2155|Compound:5570423|FD-Score:5.49|P-value:1.79E-8 ID:SGTC_2185|Compound:6113692|FD-Score:6.49|P-value:3.60E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.56|P-value:2.31E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.73|P-value:9.21E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.58|P-value:1.63E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.32|P-value:4.27E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.09|P-value:9.72E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.08|P-value:2.14E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.15|P-value:7.80E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.33|P-value:4.20E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.55|P-value:2.43E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:30.80|P-value:7.49E-210 ID:SGTC_2648|Compound:atorvastatin|FD-Score:36.90|P-value:1.15E-300 ID:SGTC_2678|Compound:equilin|FD-Score:4.48|P-value:3.40E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.47|P-value:3.55E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.67|P-value:1.13E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.78|P-value:7.37E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.21|P-value:6.38E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:37.30|P-value:2.43E-307 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.14|P-value:7.99E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:13.80|P-value:5.47E-44 ID:SGTC_2777|Compound:climbazole|FD-Score:6.07|P-value:5.58E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:10.80|P-value:7.71E-28 ID:SGTC_2790|Compound:5423970|FD-Score:3.76|P-value:8.12E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.56|P-value:1.79E-4 ID:SGTC_2935|Compound:9038016|FD-Score:8.46|P-value:1.01E-17 ID:SGTC_2937|Compound:9044753|FD-Score:3.93|P-value:3.93E-5 ID:SGTC_2938|Compound:9059746|FD-Score:4.42|P-value:4.61E-6 ID:SGTC_2959|Compound:9079155|FD-Score:-3.28|P-value:5.03E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.32|P-value:7.13E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.33|P-value:4.19E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.70|P-value:1.20E-6 ID:SGTC_3288|Compound:9119690|FD-Score:4.50|P-value:3.17E-6 ID:SGTC_3304|Compound:9125678|FD-Score:9.61|P-value:2.66E-22 ID:SGTC_3314|Compound:9135860|FD-Score:3.96|P-value:3.51E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:8.10|P-value:2.14E-16 ID:SGTC_216|Compound:k038-0035|FD-Score:3.24|P-value:5.82E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:30.20|P-value:1.04E-201 ID:SGTC_252|Compound:miconazole|FD-Score:6.10|P-value:4.50E-10 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.27|P-value:5.06E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.12|P-value:4.14E-10 ID:SGTC_279|Compound:1273-0055|FD-Score:8.66|P-value:1.83E-18 ID:SGTC_294|Compound:k038-0071|FD-Score:9.32|P-value:4.30E-21 ID:SGTC_299|Compound:1273-0059|FD-Score:4.60|P-value:1.95E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:3.15|P-value:7.75E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.67|P-value:1.16E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.67|P-value:1.36E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:3.36|P-value:3.76E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:6.48|P-value:3.86E-11 ID:SGTC_367|Compound:0335-0881|FD-Score:3.80|P-value:6.94E-5 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.32|P-value:4.25E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:-3.56|P-value:1.74E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.36|P-value:3.74E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.13|P-value:8.51E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.73|P-value:1.01E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:8.93|P-value:1.62E-19 ID:SGTC_601|Compound:0986-0029|FD-Score:4.35|P-value:6.39E-6 ID:SGTC_635|Compound:k038-0028|FD-Score:4.08|P-value:2.08E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:3.74|P-value:8.85E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:10.20|P-value:4.89E-25 ID:SGTC_794|Compound:k038-0031|FD-Score:5.40|P-value:2.99E-8 ID:SGTC_862|Compound:0452-0056|FD-Score:8.58|P-value:3.70E-18 ID:SGTC_871|Compound:0574-0004|FD-Score:8.81|P-value:4.63E-19 ID:SGTC_940|Compound:3232-1287|FD-Score:3.30|P-value:4.61E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.18|P-value:7.05E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.92|P-value:4.14E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.16|P-value:3.07E-10 ID:SGTC_1072|Compound:oxiconazole|FD-Score:5.56|P-value:1.16E-8 ID:SGTC_1084|Compound:voriconazole|FD-Score:8.15|P-value:1.40E-16 ID:SGTC_1086|Compound:cerivastatin|FD-Score:7.51|P-value:2.46E-14 ID:SGTC_1097|Compound:itavastatin|FD-Score:20.40|P-value:1.74E-93 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.49|P-value:2.26E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.95|P-value:1.18E-9 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.81|P-value:6.42E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:9.96|P-value:7.96E-24 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.64|P-value:7.57E-9 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.31|P-value:4.38E-4 ID:SGTC_1419|Compound:3993-2473|FD-Score:4.77|P-value:8.31E-7 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.31|P-value:4.53E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:5.44|P-value:2.31E-8 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.62|P-value:1.38E-4 ID:SGTC_1521|Compound:st012942|FD-Score:5.34|P-value:4.08E-8 ID:SGTC_1524|Compound:corynanthine|FD-Score:8.35|P-value:2.71E-17 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.26|P-value:5.41E-4 ID:SGTC_1638|Compound:st008370|FD-Score:4.61|P-value:1.89E-6 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:6.11|P-value:4.24E-10 ID:SGTC_1745|Compound:st081495|FD-Score:4.94|P-value:3.60E-7 ID:SGTC_1750|Compound:st081859|FD-Score:-7.05|P-value:7.15E-13 ID:SGTC_1780|Compound:st038448|FD-Score:-3.65|P-value:1.22E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.08|P-value:9.95E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:4.16|P-value:1.47E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:25.60|P-value:9.31E-146 ID:SGTC_1800|Compound:st050079|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.81|P-value:6.87E-7 ID:SGTC_1834|Compound:st055981|FD-Score:-3.83|P-value:6.15E-5 ID:SGTC_1838|Compound:st055369|FD-Score:-4.64|P-value:1.62E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-6.43|P-value:5.37E-11 ID:SGTC_1848|Compound:st056003|FD-Score:-3.18|P-value:6.96E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.15|P-value:7.95E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.31|P-value:4.43E-4 ID:SGTC_2062|Compound:5245942|FD-Score:-4.23|P-value:1.09E-5 ID:SGTC_2110|Compound:5483698|FD-Score:-3.08|P-value:9.88E-4 ID:SGTC_2147|Compound:5545932|FD-Score:3.30|P-value:4.63E-4 ID:SGTC_2155|Compound:5570423|FD-Score:5.49|P-value:1.79E-8 ID:SGTC_2185|Compound:6113692|FD-Score:6.49|P-value:3.60E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.56|P-value:2.31E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.46|P-value:2.56E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-3.73|P-value:9.21E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.58|P-value:1.63E-4 ID:SGTC_2395|Compound:5646831|FD-Score:-3.32|P-value:4.27E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.09|P-value:9.72E-4 ID:SGTC_2452|Compound:5863136|FD-Score:4.08|P-value:2.14E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.15|P-value:7.80E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.33|P-value:4.20E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.55|P-value:2.43E-6 ID:SGTC_2647|Compound:atorvastatin|FD-Score:30.80|P-value:7.49E-210 ID:SGTC_2648|Compound:atorvastatin|FD-Score:36.90|P-value:1.15E-300 ID:SGTC_2678|Compound:equilin|FD-Score:4.48|P-value:3.40E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.47|P-value:3.55E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.67|P-value:1.13E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2735|Compound:sertaconazole|FD-Score:3.78|P-value:7.37E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.21|P-value:6.38E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:37.30|P-value:2.43E-307 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.14|P-value:7.99E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:13.80|P-value:5.47E-44 ID:SGTC_2777|Compound:climbazole|FD-Score:6.07|P-value:5.58E-10 ID:SGTC_2778|Compound:tioconazole|FD-Score:10.80|P-value:7.71E-28 ID:SGTC_2790|Compound:5423970|FD-Score:3.76|P-value:8.12E-5 ID:SGTC_2807|Compound:7945238|FD-Score:3.56|P-value:1.79E-4 ID:SGTC_2935|Compound:9038016|FD-Score:8.46|P-value:1.01E-17 ID:SGTC_2937|Compound:9044753|FD-Score:3.93|P-value:3.93E-5 ID:SGTC_2938|Compound:9059746|FD-Score:4.42|P-value:4.61E-6 ID:SGTC_2959|Compound:9079155|FD-Score:-3.28|P-value:5.03E-4 ID:SGTC_2971|Compound:9092186|FD-Score:3.69|P-value:1.05E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.34|P-value:3.93E-4 ID:SGTC_3120|Compound:9124077|FD-Score:4.32|P-value:7.13E-6 ID:SGTC_3152|Compound:9099253|FD-Score:3.33|P-value:4.19E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.70|P-value:1.20E-6 ID:SGTC_3288|Compound:9119690|FD-Score:4.50|P-value:3.17E-6 ID:SGTC_3304|Compound:9125678|FD-Score:9.61|P-value:2.66E-22 ID:SGTC_3314|Compound:9135860|FD-Score:3.96|P-value:3.51E-5

Top fitness defect scores for YML075C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2753 fluvastatin 37.30 17.1 µM 2.43E-307 azole & statin 1 5.12E-305
2 SGTC_2648 atorvastatin 36.90 78.7 µM 1.15E-300 azole & statin 1 2.15E-298
3 SGTC_2647 atorvastatin 30.80 60.2 µM 7.49E-210 azole & statin 1 2.86E-208
4 SGTC_227 fluconazole 30.20 33.5 µM 1.04E-201 azole & statin 1 3.45E-200
5 SGTC_1788 fluconazole 25.60 20.0 µM 9.31E-146 azole & statin 3 1.16E-144
6 SGTC_1097 itavastatin 20.40 7.2 µM 1.74E-93 azole & statin 1 8.66E-93
7 SGTC_2765 myclobutanil 13.80 7.7 µM 5.47E-44 azole & statin 1 1.14E-43
8 SGTC_2778 tioconazole 10.80 65.1 nM 7.71E-28 ergosterol depletion effects on membrane 13 1.22E-27
9 SGTC_676 falcarinol 10.20 140.0 µM 4.89E-25 3 7.35E-25
10 SGTC_1317 1273-0028 9.96 910.0 nM 7.96E-24 azole & statin 13 1.17E-23
11 SGTC_3304 9125678 9.61 46.1 µM 2.66E-22 3 3.80E-22
12 SGTC_294 k038-0071 9.32 157.0 µM 4.30E-21 ubiquinone biosynthesis & proteasome 4 6.04E-21
13 SGTC_528 3492-0019 8.93 172.0 µM 1.62E-19 calcium & mitochondrial duress 53 2.21E-19
14 SGTC_871 0574-0004 8.81 149.0 µM 4.63E-19 7 6.27E-19
15 SGTC_279 1273-0055 8.66 2.9 µM 1.83E-18 azole & statin 1 2.45E-18
16 SGTC_862 0452-0056 8.58 10.2 µM 3.70E-18 azole & statin 8 4.93E-18
17 SGTC_2935 9038016 8.46 30.0 µM 1.01E-17 2 1.34E-17
18 SGTC_1524 corynanthine 8.35 62.1 µM 2.71E-17 1 3.56E-17
19 SGTC_1084 voriconazole 8.15 435.0 nM 1.40E-16 azole & statin 5 1.82E-16
20 SGTC_64 000l-0018 8.10 272.1 µM 2.14E-16 ubiquinone biosynthesis & proteasome 48 2.77E-16

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.438 2.18E-157 YJR049C UTR1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication
0.369 8.92E-109 YDL118W_d YDL118W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein
0.357 2.23E-101 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.310 1.85E-75 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.308 2.64E-74 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.242 5.77E-46 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.239 9.03E-45 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.231 7.28E-42 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.219 1.52E-37 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.216 1.14E-36 YHR007C ERG11 het Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
0.209 2.64E-34 YHR045W_p YHR045W_p hom Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.202 2.75E-32 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.190 1.57E-28 YPL069C BTS1 hom Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic
0.184 5.61E-27 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.182 2.47E-26 YPL061W ALD6 hom Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress