YML081C-A / ATP18

Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms

Zygosity: Homozygous strain
fixedexpanded
Profile for YML081C-A / ATP18

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:-3.62|P-value:5.65E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.70|P-value:2.05E-25 ID:SGTC_367|Compound:0335-0881|FD-Score:3.33|P-value:1.88E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.05|P-value:5.63E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.28|P-value:2.39E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.71|P-value:2.59E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.61|P-value:6.05E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.48|P-value:9.94E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.02|P-value:6.56E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.46|P-value:9.88E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.57|P-value:7.01E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:-2.94|P-value:8.78E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.73|P-value:3.72E-13 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.96|P-value:7.95E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.31|P-value:2.05E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.94|P-value:8.55E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.06|P-value:5.50E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.10|P-value:4.87E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.60|P-value:6.41E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.07|P-value:5.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.65|P-value:1.64E-16 ID:SGTC_2107|Compound:5363541|FD-Score:3.90|P-value:1.57E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.33|P-value:1.93E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.80E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.16|P-value:3.63E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.91|P-value:9.39E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.24|P-value:2.71E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.23|P-value:2.78E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.34|P-value:1.90E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.58|P-value:6.70E-5 ID:SGTC_3167|Compound:9103034|FD-Score:-3.03|P-value:6.21E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.07|P-value:5.42E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:-3.62|P-value:5.65E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:9.70|P-value:2.05E-25 ID:SGTC_367|Compound:0335-0881|FD-Score:3.33|P-value:1.88E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.05|P-value:5.63E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.28|P-value:2.39E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.71|P-value:2.59E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.61|P-value:6.05E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.48|P-value:9.94E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:-3.02|P-value:6.56E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.46|P-value:9.88E-7 ID:SGTC_1001|Compound:4048-4355|FD-Score:-3.57|P-value:7.01E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:-2.94|P-value:8.78E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.73|P-value:3.72E-13 ID:SGTC_1125|Compound:tnp00248|FD-Score:2.96|P-value:7.95E-4 ID:SGTC_1241|Compound:0364-0022|FD-Score:3.31|P-value:2.05E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.94|P-value:8.55E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.06|P-value:5.50E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.10|P-value:4.87E-4 ID:SGTC_1517|Compound:deoxycholic acid methyl ester|FD-Score:-3.60|P-value:6.41E-5 ID:SGTC_1633|Compound:st005664|FD-Score:-3.07|P-value:5.33E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.65|P-value:1.64E-16 ID:SGTC_2107|Compound:5363541|FD-Score:3.90|P-value:1.57E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-3.33|P-value:1.93E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.77|P-value:2.80E-5 ID:SGTC_2693|Compound:st077581|FD-Score:3.16|P-value:3.63E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:2.91|P-value:9.39E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.24|P-value:2.71E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.23|P-value:2.78E-4 ID:SGTC_2961|Compound:9083290|FD-Score:-3.34|P-value:1.90E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.58|P-value:6.70E-5 ID:SGTC_3167|Compound:9103034|FD-Score:-3.03|P-value:6.21E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.07|P-value:5.42E-4

Top fitness defect scores for YML081C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 9.70 5.3 µM 2.05E-25 201 1.50E-22
2 SGTC_1635 st007035 7.65 42.4 µM 1.64E-16 101 1.02E-14
3 SGTC_2107 5363541 3.90 170.2 µM 1.57E-5 8 4.84E-5
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.77 3.7 µM 2.80E-5 99 8.07E-5
5 SGTC_2978 9011784 3.58 43.0 µM 6.70E-5 45 1.74E-4
6 SGTC_669 0108-0021 3.48 26.2 µM 9.94E-5 fatty acid desaturase (OLE1) 113 2.47E-4
7 SGTC_367 0335-0881 3.33 7.1 µM 1.88E-4 ubiquinone biosynthesis & proteasome 117 4.35E-4
8 SGTC_1241 0364-0022 3.31 50.8 µM 2.05E-4 ERG2 56 4.69E-4
9 SGTC_2798 7813637 3.24 45.5 µM 2.71E-4 63 6.00E-4
10 SGTC_2934 9036370 3.23 36.9 µM 2.78E-4 65 6.15E-4
11 SGTC_2693 st077581 3.16 40.7 µM 3.63E-4 76 7.77E-4
12 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 3.05 8.0 µM 5.63E-4 65 0.00115
13 SGTC_1125 tnp00248 2.96 1.3 µM 7.95E-4 102 0.00156
14 SGTC_1251 0490-5699 2.94 265.0 µM 8.55E-4 90 0.00166
15 SGTC_2761 levamisole 2.91 97.9 µM 9.39E-4 57 0.00181
16 SGTC_543 3844-1095 2.84 191.0 µM 0.00119 ERG2 117 0.00223
17 SGTC_1630 st005209 2.84 31.3 µM 0.00121 96 0.00225
18 SGTC_2224 6650123 2.80 117.7 µM 0.00140 32 0.00257
19 SGTC_536 3852-0578 2.77 10.6 µM 0.00153 85 0.00278
20 SGTC_2770 toltrazuril 2.76 17.5 µM 0.00162 95 0.00292

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.494 2.06E-206 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.485 7.61E-198 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.484 4.31E-196 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.459 4.80E-174 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.453 2.07E-169 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.450 4.85E-167 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.444 7.23E-162 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.442 6.79E-161 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.438 3.05E-157 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.430 1.52E-151 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.429 3.77E-150 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.425 5.17E-147 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.423 6.54E-146 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.422 4.26E-145 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.418 1.26E-141 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit