YML084W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YML084W / YML084W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.93|P-value:6.26E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.07|P-value:4.57E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.88|P-value:9.43E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.92|P-value:4.73E-8 ID:SGTC_130|Compound:0136-0219|FD-Score:3.00|P-value:4.72E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.96|P-value:9.04E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.25|P-value:2.17E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.21|P-value:2.60E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.47|P-value:6.66E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.35|P-value:1.14E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.26|P-value:1.68E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.54|P-value:6.35E-10 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.16|P-value:2.49E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.71|P-value:2.22E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.84|P-value:1.57E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.48|P-value:8.17E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.04|P-value:4.06E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:2.93|P-value:6.34E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.84|P-value:8.86E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.00|P-value:4.85E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.51|P-value:7.16E-5 ID:SGTC_1797|Compound:st048695|FD-Score:2.87|P-value:7.72E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.81|P-value:9.74E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.48|P-value:6.40E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.89|P-value:1.29E-5 ID:SGTC_1959|Compound:st077091|FD-Score:2.86|P-value:8.01E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.47|P-value:6.85E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-2.91|P-value:8.28E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.38|P-value:1.01E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.28|P-value:1.54E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:2.95|P-value:5.79E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.92|P-value:6.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.30|P-value:1.41E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.07|P-value:3.56E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.23|P-value:1.90E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.02|P-value:5.47E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.22|P-value:2.49E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.02|P-value:5.49E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.21|P-value:2.08E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.53|P-value:6.60E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-2.86|P-value:9.94E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.87|P-value:1.39E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.05|P-value:4.85E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.47|P-value:6.70E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:2.93|P-value:6.26E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.07|P-value:4.57E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-2.88|P-value:9.43E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.92|P-value:4.73E-8 ID:SGTC_130|Compound:0136-0219|FD-Score:3.00|P-value:4.72E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.96|P-value:9.04E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.25|P-value:2.17E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.21|P-value:2.60E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.47|P-value:6.66E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:3.35|P-value:1.14E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:3.26|P-value:1.68E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:5.54|P-value:6.35E-10 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.16|P-value:2.49E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.71|P-value:2.22E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.84|P-value:1.57E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.48|P-value:8.17E-5 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.04|P-value:4.06E-4 ID:SGTC_1326|Compound:1431-2094|FD-Score:2.93|P-value:6.34E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:2.84|P-value:8.86E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.00|P-value:4.85E-4 ID:SGTC_1759|Compound:st043059|FD-Score:-3.51|P-value:7.16E-5 ID:SGTC_1797|Compound:st048695|FD-Score:2.87|P-value:7.72E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.81|P-value:9.74E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.48|P-value:6.40E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.89|P-value:1.29E-5 ID:SGTC_1959|Compound:st077091|FD-Score:2.86|P-value:8.01E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.47|P-value:6.85E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-2.91|P-value:8.28E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.38|P-value:1.01E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.28|P-value:1.54E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:2.95|P-value:5.79E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.92|P-value:6.40E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.30|P-value:1.41E-4 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.07|P-value:3.56E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.23|P-value:1.90E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-3.02|P-value:5.47E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-3.22|P-value:2.49E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.02|P-value:5.49E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.21|P-value:2.08E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.53|P-value:6.60E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-2.86|P-value:9.94E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.87|P-value:1.39E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.05|P-value:4.85E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.47|P-value:6.70E-5

Top fitness defect scores for YML084W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 5.54 1.8 µM 6.35E-10 44 1.54E-8
2 SGTC_1042 0350-0096 3.71 82.0 µM 2.22E-5 TSC3-RPN4 30 1.02E-4
3 SGTC_1911 st060208 3.48 74.3 µM 6.40E-5 48 2.48E-4
4 SGTC_676 falcarinol 3.47 140.0 µM 6.66E-5 71 2.56E-4
5 SGTC_3286 9117135 3.47 37.2 µM 6.70E-5 31 2.58E-4
6 SGTC_2082 5219693 3.47 150.0 µM 6.85E-5 RNA processing & uracil transport 42 2.62E-4
7 SGTC_2425 5628681 3.38 7.8 µM 1.01E-4 51 3.64E-4
8 SGTC_753 1322-0200 3.35 289.0 µM 1.14E-4 43 4.04E-4
9 SGTC_2575 plumbagin 3.30 510.0 nM 1.41E-4 superoxide 66 4.82E-4
10 SGTC_2432 5630864 3.28 12.2 µM 1.54E-4 54 5.20E-4
11 SGTC_820 1582-0060 3.26 59.9 µM 1.68E-4 64 5.60E-4
12 SGTC_2755 lomerizine 3.23 42.7 µM 1.90E-4 55 6.19E-4
13 SGTC_3025 9087895 3.21 49.5 µM 2.08E-4 PDR1 60 6.70E-4
14 SGTC_1013 4112-3890 3.16 241.0 µM 2.49E-4 TSC3-RPN4 74 7.79E-4
15 SGTC_2597 laccaic acid a 3.07 100.0 µM 3.56E-4 68 0.00105
16 SGTC_1302 1159-0335 3.04 255.0 µM 4.06E-4 36 0.00118
17 SGTC_130 0136-0219 3.00 337.7 µM 4.72E-4 66 0.00134
18 SGTC_1684 st024538 3.00 14.6 µM 4.85E-4 44 0.00137
19 SGTC_2553 4-methylesculetin 2.95 85.1 µM 5.79E-4 77 0.00159
20 SGTC_6 0844-0013 2.93 19.8 µM 6.26E-4 223 0.00170

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 5.78E-71 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.298 1.36E-69 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.291 3.23E-66 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.286 2.80E-64 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.245 4.53E-47 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.222 1.32E-38 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.215 1.44E-36 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.209 2.00E-34 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.201 9.17E-32 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.197 7.78E-31 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.195 4.46E-30 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.192 4.64E-29 YDR242W AMD2 hom Putative amidase
0.189 2.60E-28 YMR104C YPK2 hom Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication
0.188 3.69E-28 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.180 8.78E-26 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene