YML093W / UTP14

Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML093W / UTP14

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:3.65|P-value:3.54E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.47|P-value:1.14E-11 ID:SGTC_470|Compound:aa-861|FD-Score:3.34|P-value:9.56E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.87|P-value:1.69E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:5.69|P-value:8.40E-8 ID:SGTC_854|Compound:0422-0053|FD-Score:4.45|P-value:1.99E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.65|P-value:8.84E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.26|P-value:4.05E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.61|P-value:7.09E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.67|P-value:8.38E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.38|P-value:8.32E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.36|P-value:9.06E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.86|P-value:1.75E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.39|P-value:8.16E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.97|P-value:1.19E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-4.28|P-value:7.51E-5 ID:SGTC_1914|Compound:st062367|FD-Score:4.49|P-value:1.70E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.64|P-value:9.38E-6 ID:SGTC_1985|Compound:st071382|FD-Score:3.63|P-value:3.84E-4 ID:SGTC_1986|Compound:st071812|FD-Score:4.31|P-value:3.45E-5 ID:SGTC_2426|Compound:5582046|FD-Score:-3.92|P-value:2.65E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.77|P-value:4.24E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.99|P-value:2.14E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.95|P-value:1.27E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.81|P-value:2.05E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.53|P-value:5.30E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.49|P-value:5.96E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.36|P-value:9.01E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.90|P-value:2.76E-4 ID:SGTC_3310|Compound:9130229|FD-Score:5.49|P-value:2.20E-7 ID:SGTC_145|Compound:3737-0113|FD-Score:3.65|P-value:3.54E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-7.47|P-value:1.14E-11 ID:SGTC_470|Compound:aa-861|FD-Score:3.34|P-value:9.56E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:3.87|P-value:1.69E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:5.69|P-value:8.40E-8 ID:SGTC_854|Compound:0422-0053|FD-Score:4.45|P-value:1.99E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.65|P-value:8.84E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.26|P-value:4.05E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-3.61|P-value:7.09E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:4.67|P-value:8.38E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.38|P-value:8.32E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.36|P-value:9.06E-4 ID:SGTC_1732|Compound:st034308|FD-Score:3.86|P-value:1.75E-4 ID:SGTC_1776|Compound:st049249|FD-Score:3.39|P-value:8.16E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.97|P-value:1.19E-4 ID:SGTC_1895|Compound:st058434|FD-Score:-4.28|P-value:7.51E-5 ID:SGTC_1914|Compound:st062367|FD-Score:4.49|P-value:1.70E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.64|P-value:9.38E-6 ID:SGTC_1985|Compound:st071382|FD-Score:3.63|P-value:3.84E-4 ID:SGTC_1986|Compound:st071812|FD-Score:4.31|P-value:3.45E-5 ID:SGTC_2426|Compound:5582046|FD-Score:-3.92|P-value:2.65E-4 ID:SGTC_2451|Compound:5856223|FD-Score:-3.77|P-value:4.24E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.99|P-value:2.14E-6 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.95|P-value:1.27E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.81|P-value:2.05E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.53|P-value:5.30E-4 ID:SGTC_3264|Compound:9137442|FD-Score:3.49|P-value:5.96E-4 ID:SGTC_3267|Compound:9137951|FD-Score:3.36|P-value:9.01E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.90|P-value:2.76E-4 ID:SGTC_3310|Compound:9130229|FD-Score:5.49|P-value:2.20E-7

Top fitness defect scores for YML093W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_818 4072-2707 5.69 53.5 µM 8.40E-8 2 6.36E-9 0.72
2 SGTC_3310 9130229 5.49 44.1 µM 2.20E-7 Golgi 2 2.01E-8 1.10
3 SGTC_2580 diallyl disulphide 4.99 81.4 µM 2.14E-6 2 3.03E-7 0.46
4 SGTC_1220 1838-0075 4.67 193.0 µM 8.38E-6 1 1.54E-6 0.82
5 SGTC_860 0443-0016 4.65 25.1 µM 8.84E-6 3 1.64E-6 0.12
6 SGTC_1926 methyl fluorone black 4.64 53.6 µM 9.38E-6 DNA intercalators 22 1.76E-6 0.10
7 SGTC_1914 st062367 4.49 72.6 µM 1.70E-5 3 3.56E-6 0.40
8 SGTC_854 0422-0053 4.45 192.0 µM 1.99E-5 PDR1 3 4.32E-6 0.08
9 SGTC_1986 st071812 4.31 45.0 µM 3.45E-5 1 8.28E-6 0.95
10 SGTC_1042 0350-0096 4.26 82.0 µM 4.05E-5 TSC3-RPN4 7 1.00E-5 0.21
11 SGTC_1887 st057648 3.97 70.8 µM 1.19E-4 5 3.59E-5 0.21
12 SGTC_2604 4'-hydroxychalcone 3.95 11.3 µM 1.27E-4 15 3.89E-5 0.08
13 SGTC_471 1-acyl-paf 3.87 4.0 µM 1.69E-4 DNA intercalators 19 5.44E-5 0.12
14 SGTC_1732 st034308 3.86 51.8 µM 1.75E-4 11 5.65E-5 0.17
15 SGTC_3189 9110682 3.81 49.5 µM 2.05E-4 8 6.83E-5 0.00
16 SGTC_145 3737-0113 3.65 38.4 µM 3.54E-4 DNA intercalators 58 1.30E-4 0.03
17 SGTC_1985 st071382 3.63 65.5 µM 3.84E-4 5 1.44E-4 0.04
18 SGTC_3204 9114183 3.53 49.5 µM 5.30E-4 10 2.10E-4 0.10
19 SGTC_3264 9137442 3.49 49.5 µM 5.96E-4 8 2.41E-4 0.06
20 SGTC_1776 st049249 3.39 45.9 µM 8.16E-4 15 3.49E-4 0.09

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 1.93E-43 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.194 1.17E-29 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.189 3.50E-28 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.180 1.06E-25 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.179 1.41E-25 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.176 1.19E-24 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.175 2.58E-24 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.174 2.86E-24 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.173 4.83E-24 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.167 2.64E-22 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.156 9.16E-20 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.152 8.92E-19 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.148 7.63E-18 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.147 1.50E-17 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.146 1.96E-17 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p