YML102W / CAC2

Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; and chromatin dynamics during transcription

Zygosity: Homozygous strain
fixedexpanded
Profile for YML102W / CAC2

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:5.63|P-value:1.31E-8 ID:SGTC_104|Compound:0074-0074|FD-Score:3.45|P-value:3.27E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.25|P-value:6.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.03|P-value:1.25E-9 ID:SGTC_596|Compound:1155-0152|FD-Score:3.54|P-value:2.35E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.90|P-value:5.73E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:5.15|P-value:1.76E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:4.03|P-value:3.31E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.15|P-value:9.09E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.16|P-value:8.96E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.22|P-value:7.22E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.75|P-value:1.34E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.75|P-value:1.28E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-3.81|P-value:8.11E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-4.40|P-value:6.69E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-4.30|P-value:1.05E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.34|P-value:4.70E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.99|P-value:4.00E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-3.36|P-value:4.44E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.32|P-value:5.07E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.15|P-value:9.11E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.86|P-value:6.69E-5 ID:SGTC_2134|Compound:5324836|FD-Score:4.01|P-value:3.71E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.00|P-value:1.42E-23 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.87|P-value:6.49E-5 ID:SGTC_2994|Compound:9053520|FD-Score:-3.35|P-value:4.60E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.33|P-value:4.90E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.33|P-value:4.95E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.63|P-value:1.31E-8 ID:SGTC_104|Compound:0074-0074|FD-Score:3.45|P-value:3.27E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.25|P-value:6.49E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.03|P-value:1.25E-9 ID:SGTC_596|Compound:1155-0152|FD-Score:3.54|P-value:2.35E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.90|P-value:5.73E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:5.15|P-value:1.76E-7 ID:SGTC_1123|Compound:mangostin|FD-Score:4.03|P-value:3.31E-5 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.15|P-value:9.09E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.16|P-value:8.96E-4 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.22|P-value:7.22E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.75|P-value:1.34E-6 ID:SGTC_1745|Compound:st081495|FD-Score:4.75|P-value:1.28E-6 ID:SGTC_1800|Compound:st050079|FD-Score:-3.81|P-value:8.11E-5 ID:SGTC_1803|Compound:st050068|FD-Score:-4.40|P-value:6.69E-6 ID:SGTC_1818|Compound:st052136|FD-Score:-4.30|P-value:1.05E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.34|P-value:4.70E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.99|P-value:4.00E-5 ID:SGTC_1912|Compound:st060209|FD-Score:-3.36|P-value:4.44E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.32|P-value:5.07E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.15|P-value:9.11E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.20|P-value:7.83E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.86|P-value:6.69E-5 ID:SGTC_2134|Compound:5324836|FD-Score:4.01|P-value:3.71E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.00|P-value:1.42E-23 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.87|P-value:6.49E-5 ID:SGTC_2994|Compound:9053520|FD-Score:-3.35|P-value:4.60E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.56|P-value:2.13E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.33|P-value:4.90E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.33|P-value:4.95E-4

Top fitness defect scores for YML102W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 10.00 100.0 µM 1.42E-23 redox potentiating 61 4.81E-24
2 SGTC_453 enantio-paf c16 6.03 10.0 µM 1.25E-9 45 8.37E-10
3 SGTC_58 0957-0393 5.63 9.0 µM 1.31E-8 cell wall 233 9.24E-9
4 SGTC_1100 amiodarone 5.15 5.1 µM 1.76E-7 4 1.31E-7
5 SGTC_1745 st081495 4.75 74.0 µM 1.28E-6 RNA processing & uracil transport 48 9.98E-7
6 SGTC_1741 st038134 4.75 10.2 µM 1.34E-6 13 1.04E-6
7 SGTC_1123 mangostin 4.03 811.3 nM 3.31E-5 mitochondrial response to ROS 36 2.75E-5
8 SGTC_2134 5324836 4.01 1.5 µM 3.71E-5 15 3.10E-5
9 SGTC_953 1188-0045 3.90 9.7 µM 5.73E-5 60S ribosome export 29 4.83E-5
10 SGTC_2593 nobiletin 3.87 86.2 µM 6.49E-5 31 5.48E-5
11 SGTC_2117 5521686 3.86 200.0 µM 6.69E-5 15 5.65E-5
12 SGTC_3015 9080845 3.56 49.5 µM 2.13E-4 13 1.85E-4
13 SGTC_596 1155-0152 3.54 116.0 µM 2.35E-4 TRP & mitochondrial translation 55 2.04E-4
14 SGTC_104 0074-0074 3.45 591.0 µM 3.27E-4 12 2.85E-4
15 SGTC_3104 9120930 3.33 49.5 µM 4.90E-4 27 4.31E-4
16 SGTC_1940 st075990 3.32 51.1 µM 5.07E-4 60S ribosome export 44 4.46E-4
17 SGTC_1476 4112-3294 3.22 3.3 µM 7.22E-4 60S ribosome export 41 6.40E-4
18 SGTC_2051 5263410 3.20 176.0 µM 7.83E-4 41 6.96E-4
19 SGTC_1173 0443-0020 3.16 122.0 µM 8.96E-4 TSC3-RPN4 83 7.98E-4
20 SGTC_1125 tnp00248 3.15 1.3 µM 9.09E-4 85 8.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.367 8.70E-108 YML101C-A_d YML101C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.345 1.15E-94 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.322 2.53E-81 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.298 8.15E-70 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.293 1.50E-67 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.291 1.84E-66 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.281 8.93E-62 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.257 1.43E-51 YNL074C MLF3 hom Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.256 2.83E-51 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.248 3.21E-48 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.241 1.62E-45 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.237 4.90E-44 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.234 8.97E-43 YDL173W PAR32 hom Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
0.230 2.41E-41 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.229 4.91E-41 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p