YML109W / ZDS2

Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YML109W / ZDS2

Click on Significant Values for Screen Details ID:SGTC_184|Compound:1494-0393|FD-Score:-2.68|P-value:6.74E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:6.18|P-value:1.14E-13 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.44|P-value:2.31E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:2.91|P-value:2.83E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:2.70|P-value:6.84E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.47|P-value:1.92E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-2.75|P-value:5.19E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.64|P-value:8.99E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.68|P-value:6.53E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.89|P-value:3.12E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:6.47|P-value:8.16E-15 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.81|P-value:2.23E-12 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.68|P-value:7.64E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.22|P-value:6.19E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.66|P-value:6.13E-6 ID:SGTC_1678|Compound:st019265|FD-Score:2.97|P-value:2.13E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.90|P-value:2.97E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.92|P-value:2.73E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.02|P-value:1.59E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.79|P-value:3.07E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.97|P-value:2.18E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.38|P-value:3.10E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.15|P-value:8.57E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-2.70|P-value:6.19E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.86|P-value:3.56E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.61|P-value:9.25E-4 ID:SGTC_2376|Compound:9072922|FD-Score:2.63|P-value:9.39E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.15|P-value:8.31E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.04|P-value:1.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.38|P-value:2.79E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.17|P-value:3.90E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.38|P-value:2.79E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.81|P-value:5.83E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.98|P-value:1.00E-6 ID:SGTC_2706|Compound:st078239|FD-Score:-2.81|P-value:3.95E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.81|P-value:3.92E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.51|P-value:1.39E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.30|P-value:4.01E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.56|P-value:1.08E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.41|P-value:8.31E-8 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.68|P-value:6.74E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:6.18|P-value:1.14E-13 ID:SGTC_437|Compound:s-farnesyl-l-cysteine methyl ester|FD-Score:3.44|P-value:2.31E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:2.91|P-value:2.83E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:2.70|P-value:6.84E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:3.47|P-value:1.92E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-2.75|P-value:5.19E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.64|P-value:8.99E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.68|P-value:6.53E-6 ID:SGTC_1346|Compound:1488-2224|FD-Score:2.89|P-value:3.12E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:6.47|P-value:8.16E-15 ID:SGTC_1353|Compound:1498-1206|FD-Score:-5.81|P-value:2.23E-12 ID:SGTC_1411|Compound:3909-8223|FD-Score:2.68|P-value:7.64E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.22|P-value:6.19E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.66|P-value:6.13E-6 ID:SGTC_1678|Compound:st019265|FD-Score:2.97|P-value:2.13E-4 ID:SGTC_1714|Compound:st033236|FD-Score:2.90|P-value:2.97E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.92|P-value:2.73E-4 ID:SGTC_1868|Compound:st057644|FD-Score:-3.02|P-value:1.59E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.79|P-value:3.07E-6 ID:SGTC_1988|Compound:st071872|FD-Score:2.97|P-value:2.18E-4 ID:SGTC_2118|Compound:5526350|FD-Score:3.38|P-value:3.10E-5 ID:SGTC_2178|Compound:5812956|FD-Score:-3.15|P-value:8.57E-5 ID:SGTC_2241|Compound:6772625|FD-Score:-2.70|P-value:6.19E-4 ID:SGTC_2310|Compound:7668677|FD-Score:2.86|P-value:3.56E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-2.61|P-value:9.25E-4 ID:SGTC_2376|Compound:9072922|FD-Score:2.63|P-value:9.39E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.15|P-value:8.31E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.04|P-value:1.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.38|P-value:2.79E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:4.17|P-value:3.90E-7 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.38|P-value:2.79E-5 ID:SGTC_2625|Compound:euphol|FD-Score:4.81|P-value:5.83E-9 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.98|P-value:1.00E-6 ID:SGTC_2706|Compound:st078239|FD-Score:-2.81|P-value:3.95E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-2.81|P-value:3.92E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.51|P-value:1.39E-5 ID:SGTC_2802|Compound:7925815|FD-Score:-3.30|P-value:4.01E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.56|P-value:1.08E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.41|P-value:8.31E-8

Top fitness defect scores for YML109W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1348 1493-0373 6.47 93.8 µM 8.16E-15 3 4.98E-11
2 SGTC_304 1310-0298 6.18 97.0 µM 1.14E-13 cell wall 17 3.26E-10
3 SGTC_2625 euphol 4.81 100.0 µM 5.83E-9 18 7.58E-7
4 SGTC_2989 9073649 4.41 71.4 µM 8.31E-8 23 5.09E-6
5 SGTC_2584 androsterone 4.17 48.7 µM 3.90E-7 cell wall 119 1.55E-5
6 SGTC_1345 1488-0192 3.68 31.4 µM 6.53E-6 22 1.18E-4
7 SGTC_696 1560-0013 3.47 611.0 µM 1.92E-5 38 2.56E-4
8 SGTC_437 s-farnesyl-l-cysteine methyl ester 3.44 6.7 µM 2.31E-5 21 2.93E-4
9 SGTC_2118 5526350 3.38 200.0 µM 3.10E-5 29 3.63E-4
10 SGTC_2564 betulinic acid 3.04 100.0 µM 1.61E-4 75 0.00120
11 SGTC_1678 st019265 2.97 80.2 µM 2.13E-4 60S ribosome export 65 0.00147
12 SGTC_1988 st071872 2.97 53.4 µM 2.18E-4 44 0.00149
13 SGTC_1727 st034309 2.92 9.9 µM 2.73E-4 115 0.00175
14 SGTC_514 4466-0038 2.91 2.6 nM 2.83E-4 cell wall 230 0.00180
15 SGTC_1714 st033236 2.90 13.6 µM 2.97E-4 74 0.00186
16 SGTC_1346 1488-2224 2.89 62.4 µM 3.12E-4 59 0.00193
17 SGTC_2310 7668677 2.86 200.0 µM 3.56E-4 104 0.00213
18 SGTC_562 3772-2733 2.70 112.0 µM 6.84E-4 ERG2 162 0.00342
19 SGTC_1411 3909-8223 2.68 150.0 µM 7.64E-4 56 0.00371
20 SGTC_1297 1068-0111 2.64 14.1 µM 8.99E-4 73 0.00418

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 6.18E-32 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.195 4.20E-30 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.184 4.70E-27 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.176 7.23E-25 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.172 8.80E-24 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.172 1.09E-23 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.172 1.17E-23 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.163 2.30E-21 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.161 6.57E-21 YHR118C ORC6 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
0.160 1.26E-20 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.159 1.71E-20 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.158 4.45E-20 YOR094W ARF3 hom Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity
0.152 8.01E-19 YDR240C SNU56 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
0.149 4.28E-18 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.149 4.35E-18 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p