YML121W / GTR1

Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB

Zygosity: Homozygous strain
fixedexpanded
Profile for YML121W / GTR1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:6.86|P-value:1.57E-9 ID:SGTC_17|Compound:0960-0276|FD-Score:5.54|P-value:8.81E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.75|P-value:2.75E-9 ID:SGTC_52|Compound:0329-0193|FD-Score:3.84|P-value:4.86E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:10.30|P-value:2.71E-19 ID:SGTC_58|Compound:0957-0393|FD-Score:4.87|P-value:1.34E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.94|P-value:3.57E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.66|P-value:4.45E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.62|P-value:7.32E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:8.32|P-value:3.17E-13 ID:SGTC_72|Compound:0744-0168|FD-Score:4.89|P-value:1.26E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:8.06|P-value:1.59E-12 ID:SGTC_129|Compound:0088-0017|FD-Score:7.12|P-value:3.74E-10 ID:SGTC_133|Compound:0724-0033|FD-Score:3.93|P-value:3.65E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.40|P-value:2.08E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:6.01|P-value:1.05E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:5.17|P-value:4.14E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.70|P-value:7.46E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.08|P-value:1.98E-15 ID:SGTC_228|Compound:caffeine|FD-Score:11.00|P-value:9.93E-22 ID:SGTC_305|Compound:1682-2595|FD-Score:3.94|P-value:3.52E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.19|P-value:2.64E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.36|P-value:1.34E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:6.15|P-value:5.46E-8 ID:SGTC_313|Compound:3474-0040|FD-Score:3.90|P-value:4.06E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.75|P-value:2.12E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-4.22|P-value:1.05E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.28|P-value:2.69E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.68|P-value:2.76E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.42|P-value:7.04E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.99|P-value:8.48E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:3.80|P-value:5.42E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:6.35|P-value:2.14E-8 ID:SGTC_586|Compound:0957-0265|FD-Score:4.32|P-value:1.01E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.92|P-value:3.78E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.63|P-value:3.37E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:5.25|P-value:2.96E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:5.49|P-value:1.11E-6 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:4.46E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:5.87|P-value:2.00E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.99|P-value:2.29E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.12|P-value:5.17E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.91|P-value:3.88E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.06|P-value:2.39E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-6.06|P-value:5.65E-8 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.09|P-value:1.62E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.93|P-value:3.68E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:7.56|P-value:3.17E-11 ID:SGTC_1675|Compound:st018485|FD-Score:-3.78|P-value:4.45E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.87|P-value:4.36E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.46|P-value:1.25E-6 ID:SGTC_1734|Compound:st037168|FD-Score:7.38|P-value:8.82E-11 ID:SGTC_1754|Compound:st042065|FD-Score:9.89|P-value:5.53E-18 ID:SGTC_1760|Compound:st045453|FD-Score:5.07|P-value:6.26E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.55|P-value:8.38E-7 ID:SGTC_1803|Compound:st050068|FD-Score:4.78|P-value:1.88E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:39.20|P-value:9.41E-255 ID:SGTC_1849|Compound:st056239|FD-Score:3.73|P-value:6.73E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.41|P-value:1.54E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:15.20|P-value:5.75E-40 ID:SGTC_1904|Compound:st060225|FD-Score:3.89|P-value:4.18E-4 ID:SGTC_1956|Compound:st077085|FD-Score:6.21|P-value:4.21E-8 ID:SGTC_2026|Compound:5148700|FD-Score:6.37|P-value:1.95E-8 ID:SGTC_2120|Compound:5538279|FD-Score:5.03|P-value:7.23E-6 ID:SGTC_2127|Compound:5253358|FD-Score:4.14|P-value:1.87E-4 ID:SGTC_2177|Compound:5811945|FD-Score:6.13|P-value:5.96E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.44|P-value:1.34E-8 ID:SGTC_2323|Compound:6148992|FD-Score:5.00|P-value:8.18E-6 ID:SGTC_2442|Compound:5158906|FD-Score:4.89|P-value:1.27E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-3.98|P-value:2.35E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.53|P-value:8.74E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:16.60|P-value:3.41E-47 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.02|P-value:7.51E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-5.30|P-value:1.71E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.62|P-value:9.37E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.67|P-value:6.27E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.17|P-value:1.66E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-4.12|P-value:1.48E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-6.22|P-value:2.66E-8 ID:SGTC_2947|Compound:9072639|FD-Score:4.08|P-value:2.24E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.74|P-value:6.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.69|P-value:3.83E-9 ID:SGTC_3106|Compound:9121286|FD-Score:-4.19|P-value:1.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.50|P-value:1.05E-6 ID:SGTC_3266|Compound:9136860|FD-Score:4.35|P-value:9.11E-5 ID:SGTC_3350|Compound:9150499|FD-Score:3.77|P-value:5.99E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:6.86|P-value:1.57E-9 ID:SGTC_17|Compound:0960-0276|FD-Score:5.54|P-value:8.81E-7 ID:SGTC_46|Compound:0329-0187a|FD-Score:6.75|P-value:2.75E-9 ID:SGTC_52|Compound:0329-0193|FD-Score:3.84|P-value:4.86E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:10.30|P-value:2.71E-19 ID:SGTC_58|Compound:0957-0393|FD-Score:4.87|P-value:1.34E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.94|P-value:3.57E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.66|P-value:4.45E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.62|P-value:7.32E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:8.32|P-value:3.17E-13 ID:SGTC_72|Compound:0744-0168|FD-Score:4.89|P-value:1.26E-5 ID:SGTC_78|Compound:0336-0123|FD-Score:8.06|P-value:1.59E-12 ID:SGTC_129|Compound:0088-0017|FD-Score:7.12|P-value:3.74E-10 ID:SGTC_133|Compound:0724-0033|FD-Score:3.93|P-value:3.65E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.40|P-value:2.08E-16 ID:SGTC_163|Compound:1327-0036|FD-Score:6.01|P-value:1.05E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:5.17|P-value:4.14E-6 ID:SGTC_210|Compound:3551-0445|FD-Score:3.70|P-value:7.46E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:9.08|P-value:1.98E-15 ID:SGTC_228|Compound:caffeine|FD-Score:11.00|P-value:9.93E-22 ID:SGTC_305|Compound:1682-2595|FD-Score:3.94|P-value:3.52E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.19|P-value:2.64E-10 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.36|P-value:1.34E-6 ID:SGTC_311|Compound:1315-0136|FD-Score:6.15|P-value:5.46E-8 ID:SGTC_313|Compound:3474-0040|FD-Score:3.90|P-value:4.06E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.75|P-value:2.12E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-4.22|P-value:1.05E-4 ID:SGTC_398|Compound:bronopol|FD-Score:5.28|P-value:2.69E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.68|P-value:2.76E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.42|P-value:7.04E-5 ID:SGTC_530|Compound:4358-1714|FD-Score:4.99|P-value:8.48E-6 ID:SGTC_548|Compound:1436-0017|FD-Score:3.80|P-value:5.42E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:6.35|P-value:2.14E-8 ID:SGTC_586|Compound:0957-0265|FD-Score:4.32|P-value:1.01E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.92|P-value:3.78E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:4.63|P-value:3.37E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:5.25|P-value:2.96E-6 ID:SGTC_879|Compound:0831-1030|FD-Score:5.49|P-value:1.11E-6 ID:SGTC_964|Compound:1287-0107|FD-Score:4.55|P-value:4.46E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:5.87|P-value:2.00E-7 ID:SGTC_1112|Compound:tnp00069|FD-Score:-3.99|P-value:2.29E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:5.12|P-value:5.17E-6 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.91|P-value:3.88E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:4.06|P-value:2.39E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-6.06|P-value:5.65E-8 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-4.09|P-value:1.62E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.93|P-value:3.68E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:7.56|P-value:3.17E-11 ID:SGTC_1675|Compound:st018485|FD-Score:-3.78|P-value:4.45E-4 ID:SGTC_1684|Compound:st024538|FD-Score:3.87|P-value:4.36E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.46|P-value:1.25E-6 ID:SGTC_1734|Compound:st037168|FD-Score:7.38|P-value:8.82E-11 ID:SGTC_1754|Compound:st042065|FD-Score:9.89|P-value:5.53E-18 ID:SGTC_1760|Compound:st045453|FD-Score:5.07|P-value:6.26E-6 ID:SGTC_1800|Compound:st050079|FD-Score:5.55|P-value:8.38E-7 ID:SGTC_1803|Compound:st050068|FD-Score:4.78|P-value:1.88E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:39.20|P-value:9.41E-255 ID:SGTC_1849|Compound:st056239|FD-Score:3.73|P-value:6.73E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.41|P-value:1.54E-8 ID:SGTC_1877|Compound:wortmannin|FD-Score:15.20|P-value:5.75E-40 ID:SGTC_1904|Compound:st060225|FD-Score:3.89|P-value:4.18E-4 ID:SGTC_1956|Compound:st077085|FD-Score:6.21|P-value:4.21E-8 ID:SGTC_2026|Compound:5148700|FD-Score:6.37|P-value:1.95E-8 ID:SGTC_2120|Compound:5538279|FD-Score:5.03|P-value:7.23E-6 ID:SGTC_2127|Compound:5253358|FD-Score:4.14|P-value:1.87E-4 ID:SGTC_2177|Compound:5811945|FD-Score:6.13|P-value:5.96E-8 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.44|P-value:1.34E-8 ID:SGTC_2323|Compound:6148992|FD-Score:5.00|P-value:8.18E-6 ID:SGTC_2442|Compound:5158906|FD-Score:4.89|P-value:1.27E-5 ID:SGTC_2448|Compound:5185112|FD-Score:-3.98|P-value:2.35E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.53|P-value:8.74E-9 ID:SGTC_2679|Compound:rapamycin|FD-Score:16.60|P-value:3.41E-47 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.02|P-value:7.51E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-5.30|P-value:1.71E-6 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.62|P-value:9.37E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.67|P-value:6.27E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.17|P-value:1.66E-4 ID:SGTC_2930|Compound:9013230|FD-Score:-4.12|P-value:1.48E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-6.22|P-value:2.66E-8 ID:SGTC_2947|Compound:9072639|FD-Score:4.08|P-value:2.24E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.74|P-value:6.59E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.69|P-value:3.83E-9 ID:SGTC_3106|Compound:9121286|FD-Score:-4.19|P-value:1.18E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.50|P-value:1.05E-6 ID:SGTC_3266|Compound:9136860|FD-Score:4.35|P-value:9.11E-5 ID:SGTC_3350|Compound:9150499|FD-Score:3.77|P-value:5.99E-4

Top fitness defect scores for YML121W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1844 rapamycin 39.20 4.0 nM 9.41E-255 1 0
2 SGTC_2679 rapamycin 16.60 1.0 nM 3.41E-47 5 4.26E-62
3 SGTC_1877 wortmannin 15.20 25.0 µM 5.75E-40 1 1.62E-52
4 SGTC_228 caffeine 11.00 993.1 µM 9.93E-22 1 2.41E-28
5 SGTC_56 0957-0365 10.30 83.2 µM 2.71E-19 Golgi 5 4.07E-25
6 SGTC_1754 st042065 9.89 16.1 µM 5.53E-18 NEO1-PIK1 27 2.21E-23
7 SGTC_138 0850-0259 9.40 40.9 µM 2.08E-16 cell wall 48 2.71E-21
8 SGTC_221 trifluoperazine 9.08 10.3 µM 1.98E-15 NEO1-PIK1 72 5.36E-20
9 SGTC_71 0417-1750 8.32 47.8 µM 3.17E-13 Golgi 8 4.46E-17
10 SGTC_78 0336-0123 8.06 156.8 µM 1.59E-12 2 3.78E-16
11 SGTC_1601 4'-hydroxyflavanone 7.56 55.5 µM 3.17E-11 RPP1 & pyrimidine depletion 4 1.99E-14
12 SGTC_1734 st037168 7.38 69.4 µM 8.82E-11 3 7.70E-14
13 SGTC_309 k408-0051 7.19 1.5 µM 2.64E-10 7 3.28E-13
14 SGTC_129 0088-0017 7.12 176.6 µM 3.74E-10 23 5.21E-13
15 SGTC_7 0192-1582 6.86 4.2 µM 1.57E-9 17 3.49E-12
16 SGTC_46 0329-0187a 6.75 2.2 µM 2.75E-9 21 7.30E-12
17 SGTC_3037 9091026 6.69 49.5 µM 3.83E-9 NEO1-PIK1 35 1.13E-11
18 SGTC_64 000l-0018 6.66 272.1 µM 4.45E-9 ubiquinone biosynthesis & proteasome 67 1.38E-11
19 SGTC_2651 1327-0036 6.53 5.0 µM 8.74E-9 57 3.37E-11
20 SGTC_2232 chlorophetanol 6.44 41.5 µM 1.34E-8 TRP & mitochondrial translation 35 5.91E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.633 0 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.572 1.50E-289 YBR077C SLM4 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
0.528 8.34E-240 YKR007W MEH1 hom Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification
0.498 4.30E-210 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.468 1.11E-182 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.455 9.09E-171 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.387 1.36E-120 YLR114C AVL9 hom Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.367 2.22E-107 YCR075W-A_p YCR075W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication
0.353 5.79E-99 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.352 1.44E-98 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.352 3.12E-98 YPL180W TCO89 hom Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin
0.341 4.99E-92 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.336 8.58E-89 YFL024C EPL1 het Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.334 3.95E-88 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.322 1.95E-81 YNL119W NCS2 hom Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae