YML127W / RSC9

Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway

Zygosity: Heterozygous strain
fixedexpanded
Profile for YML127W / RSC9

Click on Significant Values for Screen Details ID:SGTC_1|Compound:0258-0098|FD-Score:5.79|P-value:3.83E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.95|P-value:2.84E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.96|P-value:2.65E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:10.10|P-value:2.70E-9 ID:SGTC_93|Compound:0109-0045|FD-Score:6.19|P-value:1.63E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.84|P-value:2.87E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.42|P-value:8.62E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:8.57|P-value:3.66E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:6.06|P-value:2.17E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:5.90|P-value:3.01E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:6.13|P-value:1.84E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:13.10|P-value:2.49E-14 ID:SGTC_237|Compound:nikkomycin|FD-Score:8.06|P-value:1.56E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.01|P-value:2.41E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.77|P-value:3.51E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:8.74|P-value:2.25E-7 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.43|P-value:7.88E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:6.65|P-value:5.80E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:8.26|P-value:9.04E-7 ID:SGTC_324|Compound:1315-0088|FD-Score:6.23|P-value:1.49E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:7.52|P-value:6.71E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:6.53|P-value:7.67E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:11.30|P-value:4.49E-11 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.72|P-value:4.41E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.98|P-value:2.58E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.50|P-value:6.90E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:12.50|P-value:2.75E-13 ID:SGTC_666|Compound:0272-0154|FD-Score:5.36|P-value:9.06E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:12.60|P-value:1.81E-13 ID:SGTC_709|Compound:3807-1509|FD-Score:9.43|P-value:2.67E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:6.54|P-value:7.34E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:8.46|P-value:5.09E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:10.40|P-value:1.14E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:5.69|P-value:4.68E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:17.50|P-value:5.88E-24 ID:SGTC_945|Compound:3381-0768|FD-Score:5.99|P-value:2.50E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:7.72|P-value:3.96E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:9.27|P-value:4.33E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:6.33|P-value:1.20E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:6.45|P-value:9.17E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:6.07|P-value:2.13E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.96|P-value:2.70E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:10.30|P-value:1.29E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.54|P-value:6.36E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:9.89|P-value:5.95E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:15.30|P-value:6.84E-19 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.59|P-value:6.54E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:7.29|P-value:1.23E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:7.82|P-value:3.07E-6 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:7.73|P-value:3.87E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:7.73|P-value:3.88E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:7.88|P-value:2.58E-6 ID:SGTC_1591|Compound:genipin|FD-Score:6.28|P-value:1.34E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.49|P-value:7.33E-6 ID:SGTC_1651|Compound:st011928|FD-Score:11.30|P-value:4.51E-11 ID:SGTC_1652|Compound:st011932|FD-Score:15.90|P-value:3.37E-20 ID:SGTC_1665|Compound:st014639|FD-Score:6.37|P-value:1.10E-4 ID:SGTC_1672|Compound:st016598|FD-Score:7.03|P-value:2.29E-5 ID:SGTC_1686|Compound:st019653|FD-Score:6.74|P-value:4.64E-5 ID:SGTC_1707|Compound:st032323|FD-Score:11.20|P-value:5.20E-11 ID:SGTC_1773|Compound:st048542|FD-Score:6.58|P-value:6.83E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.95|P-value:2.14E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.93|P-value:2.83E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.47|P-value:7.30E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.55|P-value:6.25E-4 ID:SGTC_2041|Compound:5107442|FD-Score:10.30|P-value:1.29E-9 ID:SGTC_2066|Compound:5222451|FD-Score:5.52|P-value:6.62E-4 ID:SGTC_2071|Compound:5230951|FD-Score:7.54|P-value:6.46E-6 ID:SGTC_2088|Compound:5278280|FD-Score:5.44|P-value:7.71E-4 ID:SGTC_2109|Compound:5483026|FD-Score:18.10|P-value:1.60E-25 ID:SGTC_2111|Compound:5486399|FD-Score:13.20|P-value:1.40E-14 ID:SGTC_2186|Compound:6124449|FD-Score:13.60|P-value:2.44E-15 ID:SGTC_2225|Compound:6654152|FD-Score:13.80|P-value:1.07E-15 ID:SGTC_2229|Compound:7354935|FD-Score:9.25|P-value:4.62E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.46|P-value:5.03E-7 ID:SGTC_2261|Compound:9010538|FD-Score:-6.69|P-value:8.95E-5 ID:SGTC_2301|Compound:7769476|FD-Score:8.02|P-value:1.79E-6 ID:SGTC_2344|Compound:7990960|FD-Score:8.09|P-value:1.45E-6 ID:SGTC_2346|Compound:9031566|FD-Score:10.50|P-value:6.46E-10 ID:SGTC_2348|Compound:9022543|FD-Score:9.45|P-value:2.45E-8 ID:SGTC_2361|Compound:9034121|FD-Score:11.10|P-value:7.51E-11 ID:SGTC_2375|Compound:9072683|FD-Score:7.19|P-value:1.58E-5 ID:SGTC_2378|Compound:9074213|FD-Score:6.39|P-value:1.04E-4 ID:SGTC_2380|Compound:9035439|FD-Score:5.78|P-value:3.89E-4 ID:SGTC_2396|Compound:5342950|FD-Score:10.00|P-value:4.10E-9 ID:SGTC_2400|Compound:5203494|FD-Score:8.99|P-value:1.06E-7 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:10.90|P-value:1.93E-10 ID:SGTC_2451|Compound:5856223|FD-Score:5.51|P-value:6.69E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:5.57|P-value:5.98E-4 ID:SGTC_2534|Compound:helenine|FD-Score:10.40|P-value:1.00E-9 ID:SGTC_2544|Compound:sphondin|FD-Score:8.47|P-value:4.92E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:6.11|P-value:1.92E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:7.58|P-value:5.78E-6 ID:SGTC_2747|Compound:doxorubicin|FD-Score:6.51|P-value:7.92E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:8.53|P-value:4.20E-7 ID:SGTC_2837|Compound:9008476|FD-Score:6.24|P-value:1.46E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.97|P-value:2.64E-4 ID:SGTC_2912|Compound:7964298|FD-Score:14.00|P-value:5.11E-16 ID:SGTC_2928|Compound:9011484|FD-Score:7.36|P-value:1.01E-5 ID:SGTC_3031|Compound:9088762|FD-Score:6.14|P-value:1.83E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.06|P-value:2.15E-4 ID:SGTC_3120|Compound:9124077|FD-Score:6.15|P-value:1.79E-4 ID:SGTC_3170|Compound:9103054|FD-Score:5.34|P-value:9.27E-4 ID:SGTC_3247|Compound:9135149|FD-Score:6.74|P-value:4.67E-5 ID:SGTC_3266|Compound:9136860|FD-Score:9.55|P-value:1.83E-8 ID:SGTC_3277|Compound:9138724|FD-Score:9.50|P-value:2.09E-8 ID:SGTC_3299|Compound:9121982|FD-Score:8.33|P-value:7.37E-7 ID:SGTC_3304|Compound:9125678|FD-Score:14.00|P-value:4.11E-16 ID:SGTC_3321|Compound:9137793|FD-Score:5.39|P-value:8.46E-4 ID:SGTC_1|Compound:0258-0098|FD-Score:5.79|P-value:3.83E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:6.95|P-value:2.84E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:5.96|P-value:2.65E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:10.10|P-value:2.70E-9 ID:SGTC_93|Compound:0109-0045|FD-Score:6.19|P-value:1.63E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:7.84|P-value:2.87E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:7.42|P-value:8.62E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:8.57|P-value:3.66E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:6.06|P-value:2.17E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:5.90|P-value:3.01E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:6.13|P-value:1.84E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:13.10|P-value:2.49E-14 ID:SGTC_237|Compound:nikkomycin|FD-Score:8.06|P-value:1.56E-6 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.01|P-value:2.41E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.77|P-value:3.51E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:8.74|P-value:2.25E-7 ID:SGTC_272|Compound:doxorubicin|FD-Score:5.43|P-value:7.88E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:6.65|P-value:5.80E-5 ID:SGTC_322|Compound:k048-0136|FD-Score:8.26|P-value:9.04E-7 ID:SGTC_324|Compound:1315-0088|FD-Score:6.23|P-value:1.49E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:7.52|P-value:6.71E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:6.53|P-value:7.67E-5 ID:SGTC_445|Compound:e6 berbamine|FD-Score:11.30|P-value:4.49E-11 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:5.72|P-value:4.41E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.98|P-value:2.58E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.50|P-value:6.90E-4 ID:SGTC_643|Compound:k048-0106|FD-Score:12.50|P-value:2.75E-13 ID:SGTC_666|Compound:0272-0154|FD-Score:5.36|P-value:9.06E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:12.60|P-value:1.81E-13 ID:SGTC_709|Compound:3807-1509|FD-Score:9.43|P-value:2.67E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:6.54|P-value:7.34E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:8.46|P-value:5.09E-7 ID:SGTC_871|Compound:0574-0004|FD-Score:10.40|P-value:1.14E-9 ID:SGTC_885|Compound:0865-0106|FD-Score:5.69|P-value:4.68E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:17.50|P-value:5.88E-24 ID:SGTC_945|Compound:3381-0768|FD-Score:5.99|P-value:2.50E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:7.72|P-value:3.96E-6 ID:SGTC_1050|Compound:3232-1156|FD-Score:9.27|P-value:4.33E-8 ID:SGTC_1082|Compound:camptothecin|FD-Score:6.33|P-value:1.20E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:6.45|P-value:9.17E-5 ID:SGTC_1168|Compound:k815-0004|FD-Score:6.07|P-value:2.13E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:5.96|P-value:2.70E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:10.30|P-value:1.29E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.54|P-value:6.36E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:9.89|P-value:5.95E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:15.30|P-value:6.84E-19 ID:SGTC_1453|Compound:4237-0541|FD-Score:6.59|P-value:6.54E-5 ID:SGTC_1483|Compound:3453-0561|FD-Score:7.29|P-value:1.23E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:7.82|P-value:3.07E-6 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:7.73|P-value:3.87E-6 ID:SGTC_1583|Compound:clindamycin|FD-Score:7.73|P-value:3.88E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:7.88|P-value:2.58E-6 ID:SGTC_1591|Compound:genipin|FD-Score:6.28|P-value:1.34E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:7.49|P-value:7.33E-6 ID:SGTC_1651|Compound:st011928|FD-Score:11.30|P-value:4.51E-11 ID:SGTC_1652|Compound:st011932|FD-Score:15.90|P-value:3.37E-20 ID:SGTC_1665|Compound:st014639|FD-Score:6.37|P-value:1.10E-4 ID:SGTC_1672|Compound:st016598|FD-Score:7.03|P-value:2.29E-5 ID:SGTC_1686|Compound:st019653|FD-Score:6.74|P-value:4.64E-5 ID:SGTC_1707|Compound:st032323|FD-Score:11.20|P-value:5.20E-11 ID:SGTC_1773|Compound:st048542|FD-Score:6.58|P-value:6.83E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:7.95|P-value:2.14E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:5.93|P-value:2.83E-4 ID:SGTC_1936|Compound:st074407|FD-Score:5.47|P-value:7.30E-4 ID:SGTC_1991|Compound:st073000|FD-Score:5.55|P-value:6.25E-4 ID:SGTC_2041|Compound:5107442|FD-Score:10.30|P-value:1.29E-9 ID:SGTC_2066|Compound:5222451|FD-Score:5.52|P-value:6.62E-4 ID:SGTC_2071|Compound:5230951|FD-Score:7.54|P-value:6.46E-6 ID:SGTC_2088|Compound:5278280|FD-Score:5.44|P-value:7.71E-4 ID:SGTC_2109|Compound:5483026|FD-Score:18.10|P-value:1.60E-25 ID:SGTC_2111|Compound:5486399|FD-Score:13.20|P-value:1.40E-14 ID:SGTC_2186|Compound:6124449|FD-Score:13.60|P-value:2.44E-15 ID:SGTC_2225|Compound:6654152|FD-Score:13.80|P-value:1.07E-15 ID:SGTC_2229|Compound:7354935|FD-Score:9.25|P-value:4.62E-8 ID:SGTC_2233|Compound:sulbentine|FD-Score:8.46|P-value:5.03E-7 ID:SGTC_2261|Compound:9010538|FD-Score:-6.69|P-value:8.95E-5 ID:SGTC_2301|Compound:7769476|FD-Score:8.02|P-value:1.79E-6 ID:SGTC_2344|Compound:7990960|FD-Score:8.09|P-value:1.45E-6 ID:SGTC_2346|Compound:9031566|FD-Score:10.50|P-value:6.46E-10 ID:SGTC_2348|Compound:9022543|FD-Score:9.45|P-value:2.45E-8 ID:SGTC_2361|Compound:9034121|FD-Score:11.10|P-value:7.51E-11 ID:SGTC_2375|Compound:9072683|FD-Score:7.19|P-value:1.58E-5 ID:SGTC_2378|Compound:9074213|FD-Score:6.39|P-value:1.04E-4 ID:SGTC_2380|Compound:9035439|FD-Score:5.78|P-value:3.89E-4 ID:SGTC_2396|Compound:5342950|FD-Score:10.00|P-value:4.10E-9 ID:SGTC_2400|Compound:5203494|FD-Score:8.99|P-value:1.06E-7 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:10.90|P-value:1.93E-10 ID:SGTC_2451|Compound:5856223|FD-Score:5.51|P-value:6.69E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:5.57|P-value:5.98E-4 ID:SGTC_2534|Compound:helenine|FD-Score:10.40|P-value:1.00E-9 ID:SGTC_2544|Compound:sphondin|FD-Score:8.47|P-value:4.92E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:6.11|P-value:1.92E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:7.58|P-value:5.78E-6 ID:SGTC_2747|Compound:doxorubicin|FD-Score:6.51|P-value:7.92E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:8.53|P-value:4.20E-7 ID:SGTC_2837|Compound:9008476|FD-Score:6.24|P-value:1.46E-4 ID:SGTC_2890|Compound:9046729|FD-Score:5.97|P-value:2.64E-4 ID:SGTC_2912|Compound:7964298|FD-Score:14.00|P-value:5.11E-16 ID:SGTC_2928|Compound:9011484|FD-Score:7.36|P-value:1.01E-5 ID:SGTC_3031|Compound:9088762|FD-Score:6.14|P-value:1.83E-4 ID:SGTC_3037|Compound:9091026|FD-Score:6.06|P-value:2.15E-4 ID:SGTC_3120|Compound:9124077|FD-Score:6.15|P-value:1.79E-4 ID:SGTC_3170|Compound:9103054|FD-Score:5.34|P-value:9.27E-4 ID:SGTC_3247|Compound:9135149|FD-Score:6.74|P-value:4.67E-5 ID:SGTC_3266|Compound:9136860|FD-Score:9.55|P-value:1.83E-8 ID:SGTC_3277|Compound:9138724|FD-Score:9.50|P-value:2.09E-8 ID:SGTC_3299|Compound:9121982|FD-Score:8.33|P-value:7.37E-7 ID:SGTC_3304|Compound:9125678|FD-Score:14.00|P-value:4.11E-16 ID:SGTC_3321|Compound:9137793|FD-Score:5.39|P-value:8.46E-4

Top fitness defect scores for YML127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2109 5483026 18.10 200.0 µM 1.60E-25 RSC complex & mRNA processing 3 2.06E-73 4.78
2 SGTC_928 2764-0428 17.50 58.7 µM 5.88E-24 cell wall 1 1.17E-68 3.60
3 SGTC_1652 st011932 15.90 78.0 µM 3.37E-20 RSC complex & mRNA processing 5 2.99E-57 1.25
4 SGTC_1374 2889-5571 15.30 141.0 µM 6.84E-19 RSC complex & mRNA processing 3 2.72E-53 0.20
5 SGTC_3304 9125678 14.00 46.1 µM 4.11E-16 10 6.98E-45 3.45
6 SGTC_2912 7964298 14.00 10.9 µM 5.11E-16 cell wall 6 1.35E-44 0.38
7 SGTC_2225 6654152 13.80 15.4 µM 1.07E-15 3 1.25E-43 1.46
8 SGTC_2186 6124449 13.60 200.0 µM 2.44E-15 RSC complex & mRNA processing 4 1.52E-42 1.76
9 SGTC_2111 5486399 13.20 200.0 µM 1.40E-14 4 2.93E-40 0.46
10 SGTC_227 fluconazole 13.10 33.5 µM 2.49E-14 azole & statin 8 1.68E-39 0.24
11 SGTC_673 1082-0474 12.60 110.0 µM 1.81E-13 RSC complex & mRNA processing 5 6.70E-37 0.68
12 SGTC_643 k048-0106 12.50 28.4 µM 2.75E-13 RSC & ERG11 4 2.36E-36 2.76
13 SGTC_445 e6 berbamine 11.30 66.0 µM 4.49E-11 NEO1-PIK1 5 1.06E-29 3.41
14 SGTC_1651 st011928 11.30 86.1 µM 4.51E-11 RSC complex & mRNA processing 1 1.08E-29 3.36
15 SGTC_1707 st032323 11.20 6.3 µM 5.20E-11 DNA damage response 4 1.64E-29 0.62
16 SGTC_2361 9034121 11.10 116.0 µM 7.51E-11 RSC complex & mRNA processing 2 4.97E-29 1.48
17 SGTC_2410 aloe-emodin-8-o-glycoside 10.90 46.3 µM 1.93E-10 mitochondrial processes 1 8.35E-28 5.58
18 SGTC_2346 9031566 10.50 143.8 µM 6.46E-10 Golgi 1 3.14E-26 1.56
19 SGTC_2534 helenine 10.40 20.1 µM 1.00E-9 RSC complex & mRNA processing 4 1.17E-25 1.56
20 SGTC_871 0574-0004 10.40 149.0 µM 1.14E-9 3 1.73E-25 0.20

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.677 0 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.644 0 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.534 7.95E-247 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.493 6.03E-205 YIL126W STH1 het ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
0.479 2.96E-192 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.474 7.73E-188 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.469 1.63E-183 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.452 2.42E-168 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.446 7.57E-163 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.364 6.97E-106 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.353 5.96E-99 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.343 3.02E-93 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.341 7.43E-92 YAL001C TFC3 het Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
0.340 1.58E-91 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.335 6.44E-89 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients