HIPHOP chemogenomics database

YMR001C / CDC5

Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate

Zygosity: Heterozygous strain

fixedexpanded
Profile for YMR001C / CDC5

Click on Significant Values for Screen Details

Top fitness defect scores for YMR001C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_3043	9092303	6.30	49.5 µM	1.25E-10		1	1.53E-10	0.99
2	SGTC_916	4466-0038	6.25	42.0 nM	1.67E-10	cell wall	13	2.04E-10	0.77
3	SGTC_3034	9090421	6.24	49.5 µM	1.77E-10	60S ribosome export	2	2.16E-10	2.47
4	SGTC_145	3737-0113	6.04	38.4 µM	6.32E-10	DNA intercalators	18	7.72E-10	0.40
5	SGTC_2584	androsterone	5.89	48.7 µM	1.58E-9	cell wall	11	1.93E-9	0.01
6	SGTC_3013	9080133	5.63	71.4 µM	7.44E-9		1	9.05E-9	1.40
7	SGTC_2619	obliquin	5.57	87.9 µM	1.03E-8	cell wall	17	1.25E-8	0.04
8	SGTC_3150	9097574	4.67	49.5 µM	1.23E-6		1	1.47E-6	0.50
9	SGTC_1800	st050079	4.67	29.1 µM	1.26E-6	NEO1-PIK1	16	1.51E-6	0.07
10	SGTC_1561	5-methoxyflavone	4.45	52.9 µM	3.57E-6		2	4.27E-6	1.03
11	SGTC_3003	9075612	4.44	71.4 µM	3.70E-6		5	4.42E-6	0.34
12	SGTC_2489	cantharidin	4.44	73.4 µM	3.81E-6	cell wall signaling	5	4.55E-6	0.05
13	SGTC_3350	9150499	4.20	3.6 µM	1.14E-5	cell wall	13	1.36E-5	0.00
14	SGTC_256	clotrimazole	4.17	625.0 nM	1.29E-5	ergosterol depletion effects on membrane	17	1.53E-5	0.03
15	SGTC_144	4161-2749	3.96	112.4 µM	3.15E-5	DNA intercalators	18	3.72E-5	0.09
16	SGTC_2006	4011487	3.96	200.0 µM	3.22E-5	endomembrane recycling	17	3.80E-5	0.09
17	SGTC_1926	methyl fluorone black	3.84	53.6 µM	5.30E-5	DNA intercalators	29	6.24E-5	0.04
18	SGTC_2902	5787006	3.80	60.5 µM	6.27E-5	Golgi	5	7.38E-5	0.15
19	SGTC_58	0957-0393	3.78	9.0 µM	6.59E-5	cell wall	53	7.75E-5	0.09
20	SGTC_775	4577-0580	3.77	57.3 µM	6.97E-5		6	8.20E-5	0.18

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.268	5.13E-56	YMR124W_p	YMR124W_p	hom	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.246	1.93E-47	YJL159W	HSP150	hom	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.228	1.52E-40	YLL032C	YLL032C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.221	3.51E-38	YPL115C	BEM3	hom	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.216	1.34E-36	YLR212C	TUB4	het	Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.215	2.92E-36	YJR054W	KCH1	hom	Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.193	1.56E-29	YGL118C_d	YGL118C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.181	4.01E-26	YDL203C	ACK1	hom	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.181	5.02E-26	YEL061C	CIN8	hom	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.178	3.73E-25	YHR149C	SKG6	hom	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.177	4.59E-25	YMR168C	CEP3	het	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.176	8.95E-25	YJR142W_p	YJR142W_p	hom	Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.175	2.18E-24	YJL099W	CHS6	hom	Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.171	2.61E-23	YDR401W_d	YDR401W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.170	4.41E-23	YMR289W	ABZ2	hom	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis