YMR003W / AIM34

Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR003W / AIM34

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:3.55|P-value:1.10E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:4.97|P-value:1.15E-7 ID:SGTC_107|Compound:0358-0022|FD-Score:3.00|P-value:9.17E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.21|P-value:3.73E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-2.95|P-value:9.62E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.97|P-value:8.74E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.07|P-value:7.03E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:2.99|P-value:9.64E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.22|P-value:4.15E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:5.32|P-value:1.50E-8 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.34|P-value:2.23E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.13|P-value:4.95E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-2.94|P-value:9.80E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.99|P-value:9.42E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.69|P-value:5.27E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.05|P-value:7.77E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.30|P-value:3.82E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.15|P-value:5.40E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.27|P-value:3.44E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.45|P-value:6.72E-9 ID:SGTC_1741|Compound:st038134|FD-Score:-5.19|P-value:2.51E-8 ID:SGTC_1920|Compound:st075728|FD-Score:-3.43|P-value:1.53E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.19|P-value:4.53E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.20|P-value:3.75E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.01|P-value:8.95E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:2.98|P-value:9.93E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.19|P-value:4.66E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.22|P-value:4.14E-4 ID:SGTC_2837|Compound:9008476|FD-Score:5.76|P-value:9.66E-10 ID:SGTC_3145|Compound:9085516|FD-Score:-3.10|P-value:5.44E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.55|P-value:1.10E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:4.97|P-value:1.15E-7 ID:SGTC_107|Compound:0358-0022|FD-Score:3.00|P-value:9.17E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.21|P-value:3.73E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-2.95|P-value:9.62E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-2.97|P-value:8.74E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.07|P-value:7.03E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:2.99|P-value:9.64E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.22|P-value:4.15E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:5.32|P-value:1.50E-8 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.34|P-value:2.23E-4 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:-3.13|P-value:4.95E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-2.94|P-value:9.80E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.08|P-value:6.80E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.99|P-value:9.42E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:-3.69|P-value:5.27E-5 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.05|P-value:7.77E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.30|P-value:3.82E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.15|P-value:5.40E-4 ID:SGTC_1526|Compound:st051518|FD-Score:3.27|P-value:3.44E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.45|P-value:6.72E-9 ID:SGTC_1741|Compound:st038134|FD-Score:-5.19|P-value:2.51E-8 ID:SGTC_1920|Compound:st075728|FD-Score:-3.43|P-value:1.53E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.19|P-value:4.53E-4 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:-3.20|P-value:3.75E-4 ID:SGTC_1991|Compound:st073000|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_2032|Compound:5185112|FD-Score:3.01|P-value:8.95E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:4.00|P-value:1.59E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:2.98|P-value:9.93E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.19|P-value:4.66E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:3.22|P-value:4.14E-4 ID:SGTC_2837|Compound:9008476|FD-Score:5.76|P-value:9.66E-10 ID:SGTC_3145|Compound:9085516|FD-Score:-3.10|P-value:5.44E-4

Top fitness defect scores for YMR003W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2837 9008476 5.76 45.5 µM 9.66E-10 7 4.16E-9
2 SGTC_1738 st035555 5.45 74.0 µM 6.72E-9 TSC3-RPN4 9 2.48E-8
3 SGTC_872 0588-0139 5.32 234.0 µM 1.50E-8 12 5.17E-8
4 SGTC_106 0092-0003 4.97 11.6 µM 1.15E-7 copper-dependent oxidative stress 9 3.38E-7
5 SGTC_1338 1486-1223 4.30 76.0 µM 3.82E-6 11 8.54E-6
6 SGTC_2518 prenyletin 4.00 46.3 µM 1.59E-5 10 3.19E-5
7 SGTC_60 0986-0278 3.55 202.0 µM 1.10E-4 23 1.90E-4
8 SGTC_1611 st001856 3.52 99.4 µM 1.25E-4 28 2.13E-4
9 SGTC_1991 st073000 3.28 8.9 µM 3.32E-4 NEO1 115 5.26E-4
10 SGTC_1526 st051518 3.27 75.0 µM 3.44E-4 44 5.44E-4
11 SGTC_2739 tacrine 3.22 100.9 µM 4.14E-4 heme requiring 40 6.46E-4
12 SGTC_824 1304-0008 3.22 100.0 µM 4.15E-4 DNA damage response 65 6.48E-4
13 SGTC_1926 methyl fluorone black 3.19 53.6 µM 4.53E-4 DNA intercalators 92 7.01E-4
14 SGTC_2707 st078556 3.19 66.6 µM 4.66E-4 29 7.21E-4
15 SGTC_1414 3917-0015 3.15 5.4 µM 5.40E-4 31 8.26E-4
16 SGTC_1194 1488-0194 3.09 225.0 µM 6.58E-4 70 9.92E-4
17 SGTC_1089 terbinafine 3.08 2.2 µM 6.80E-4 45 0.00102
18 SGTC_454 lyso-paf C-16 3.07 6.7 µM 7.03E-4 59 0.00105
19 SGTC_1295 1013-0063 3.05 9.8 µM 7.77E-4 44 0.00116
20 SGTC_2032 5185112 3.01 26.0 µM 8.95E-4 41 0.00132

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.128 9.20E-14 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.109 2.47E-10 YNR054C ESF2 het Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
0.099 1.08E-8 YIR042C_p YIR042C_p hom Putative protein of unknown function; YIR042C is a non-essential gene
0.094 4.25E-8 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.094 5.46E-8 YNR001C CIT1 hom Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication
0.090 1.94E-7 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.085 8.99E-7 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.082 2.07E-6 YOL035C_d YOL035C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.36E-6 YMR160W YMR160W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress
0.080 3.96E-6 YLR124W_d YLR124W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 5.18E-6 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.076 9.64E-6 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.074 1.64E-5 YPL165C SET6 hom SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
0.074 1.67E-5 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.073 2.38E-5 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication