YMR015C / ERG5

C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR015C / ERG5

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:5.05|P-value:2.19E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:6.51|P-value:6.55E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:6.47|P-value:7.93E-8 ID:SGTC_21|Compound:0849-0113|FD-Score:6.36|P-value:1.27E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:7.48|P-value:6.62E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:8.07|P-value:3.06E-11 ID:SGTC_43|Compound:0570-0105|FD-Score:13.80|P-value:1.70E-29 ID:SGTC_49|Compound:0717-0965|FD-Score:4.90|P-value:3.68E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-12.00|P-value:1.02E-22 ID:SGTC_59|Compound:0330-0160|FD-Score:4.00|P-value:6.13E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.21|P-value:2.45E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:17.00|P-value:1.29E-43 ID:SGTC_87|Compound:0100-0052|FD-Score:5.86|P-value:1.03E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.10|P-value:1.83E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.03|P-value:5.64E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:10.00|P-value:1.90E-16 ID:SGTC_146|Compound:3448-8650|FD-Score:9.97|P-value:3.18E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:14.60|P-value:1.04E-32 ID:SGTC_161|Compound:4065-0411|FD-Score:3.83|P-value:9.72E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.69|P-value:2.03E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:8.47|P-value:3.36E-12 ID:SGTC_200|Compound:k038-0079|FD-Score:5.19|P-value:1.32E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:6.17|P-value:2.88E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:4.72|P-value:6.75E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.53|P-value:1.21E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.54|P-value:1.18E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.21|P-value:3.01E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.44|P-value:9.02E-8 ID:SGTC_351|Compound:caspofungin|FD-Score:8.50|P-value:2.85E-12 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.89|P-value:7.55E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:10.40|P-value:2.14E-17 ID:SGTC_377|Compound:3970-0964|FD-Score:7.91|P-value:7.34E-11 ID:SGTC_435|Compound:c-PAF|FD-Score:4.69|P-value:7.27E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:7.87|P-value:9.19E-11 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.08|P-value:4.78E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.50|P-value:1.36E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:10.00|P-value:2.47E-16 ID:SGTC_505|Compound:gw-5074|FD-Score:5.27|P-value:9.74E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:8.91|P-value:2.56E-13 ID:SGTC_562|Compound:3772-2733|FD-Score:9.38|P-value:1.43E-14 ID:SGTC_614|Compound:0462-0418|FD-Score:4.07|P-value:5.00E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:7.64|P-value:2.93E-10 ID:SGTC_642|Compound:0335-0876|FD-Score:11.10|P-value:8.34E-20 ID:SGTC_658|Compound:3253-0951|FD-Score:4.90|P-value:3.58E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:6.42|P-value:1.01E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:5.70|P-value:1.96E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:4.05|P-value:5.31E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.28|P-value:2.70E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:10.50|P-value:1.02E-17 ID:SGTC_804|Compound:1595-0054|FD-Score:4.39|P-value:1.90E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:6.04|P-value:5.00E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:11.10|P-value:1.26E-19 ID:SGTC_852|Compound:0418-0143|FD-Score:13.30|P-value:1.77E-27 ID:SGTC_863|Compound:0466-0191|FD-Score:10.10|P-value:1.19E-16 ID:SGTC_878|Compound:0828-0289|FD-Score:4.12|P-value:4.24E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.88|P-value:8.56E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.84|P-value:9.52E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.96|P-value:6.85E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:7.52|P-value:5.50E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.35|P-value:1.33E-7 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.20|P-value:1.29E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.16|P-value:3.53E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.49|P-value:4.34E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.69|P-value:7.42E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:7.44|P-value:8.42E-10 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.90|P-value:3.67E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.71|P-value:6.92E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.40|P-value:1.83E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.02|P-value:2.44E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-5.02|P-value:2.16E-5 ID:SGTC_1687|Compound:st020778|FD-Score:14.50|P-value:2.10E-32 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.19|P-value:2.62E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.86|P-value:4.20E-5 ID:SGTC_1941|Compound:st076221|FD-Score:5.16|P-value:1.47E-5 ID:SGTC_1994|Compound:st072947|FD-Score:4.03|P-value:5.58E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.91|P-value:3.54E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-3.88|P-value:7.90E-4 ID:SGTC_2077|Compound:5212015|FD-Score:8.24|P-value:1.23E-11 ID:SGTC_2200|Compound:6600604|FD-Score:4.27|P-value:2.78E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-4.67|P-value:7.12E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.93|P-value:7.30E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.60|P-value:9.95E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.16|P-value:3.01E-7 ID:SGTC_2351|Compound:9026858|FD-Score:6.96|P-value:8.46E-9 ID:SGTC_2445|Compound:5742597|FD-Score:4.05|P-value:5.32E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.73|P-value:1.89E-10 ID:SGTC_2720|Compound:fluspirilene|FD-Score:5.27|P-value:9.86E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-7.14|P-value:3.10E-9 ID:SGTC_2740|Compound:felodipine|FD-Score:4.83|P-value:4.62E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:5.57|P-value:3.21E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.90|P-value:6.49E-19 ID:SGTC_2858|Compound:9025781|FD-Score:9.95|P-value:3.50E-16 ID:SGTC_2884|Compound:9058502|FD-Score:4.82|P-value:4.74E-5 ID:SGTC_2896|Compound:9052656|FD-Score:9.76|P-value:1.27E-15 ID:SGTC_2923|Compound:7992654|FD-Score:3.98|P-value:6.50E-4 ID:SGTC_2955|Compound:9076254|FD-Score:5.02|P-value:2.43E-5 ID:SGTC_2966|Compound:9084041|FD-Score:4.94|P-value:3.17E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.89|P-value:8.29E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.52|P-value:1.28E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-5.15|P-value:1.37E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-4.35|P-value:1.96E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.36|P-value:7.18E-6 ID:SGTC_3263|Compound:9137018|FD-Score:4.61|P-value:9.64E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-4.16|P-value:3.53E-4 ID:SGTC_3330|Compound:9141424|FD-Score:6.06|P-value:4.63E-7 ID:SGTC_3334|Compound:9142812|FD-Score:5.41|P-value:5.98E-6 ID:SGTC_3338|Compound:9144300|FD-Score:5.21|P-value:1.24E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:5.05|P-value:2.19E-5 ID:SGTC_8|Compound:0354-0001|FD-Score:6.51|P-value:6.55E-8 ID:SGTC_18|Compound:0111-0177|FD-Score:6.47|P-value:7.93E-8 ID:SGTC_21|Compound:0849-0113|FD-Score:6.36|P-value:1.27E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:7.48|P-value:6.62E-10 ID:SGTC_36|Compound:0335-0881|FD-Score:8.07|P-value:3.06E-11 ID:SGTC_43|Compound:0570-0105|FD-Score:13.80|P-value:1.70E-29 ID:SGTC_49|Compound:0717-0965|FD-Score:4.90|P-value:3.68E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-12.00|P-value:1.02E-22 ID:SGTC_59|Compound:0330-0160|FD-Score:4.00|P-value:6.13E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:6.21|P-value:2.45E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:17.00|P-value:1.29E-43 ID:SGTC_87|Compound:0100-0052|FD-Score:5.86|P-value:1.03E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.10|P-value:1.83E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.03|P-value:5.64E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:10.00|P-value:1.90E-16 ID:SGTC_146|Compound:3448-8650|FD-Score:9.97|P-value:3.18E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:14.60|P-value:1.04E-32 ID:SGTC_161|Compound:4065-0411|FD-Score:3.83|P-value:9.72E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:5.69|P-value:2.03E-6 ID:SGTC_187|Compound:1488-2104|FD-Score:8.47|P-value:3.36E-12 ID:SGTC_200|Compound:k038-0079|FD-Score:5.19|P-value:1.32E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:6.17|P-value:2.88E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:4.72|P-value:6.75E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:4.53|P-value:1.21E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:4.54|P-value:1.18E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.21|P-value:3.01E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.44|P-value:9.02E-8 ID:SGTC_351|Compound:caspofungin|FD-Score:8.50|P-value:2.85E-12 ID:SGTC_360|Compound:0957-0399|FD-Score:-3.89|P-value:7.55E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:10.40|P-value:2.14E-17 ID:SGTC_377|Compound:3970-0964|FD-Score:7.91|P-value:7.34E-11 ID:SGTC_435|Compound:c-PAF|FD-Score:4.69|P-value:7.27E-5 ID:SGTC_450|Compound:aminopyrene|FD-Score:7.87|P-value:9.19E-11 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.08|P-value:4.78E-4 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.50|P-value:1.36E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:10.00|P-value:2.47E-16 ID:SGTC_505|Compound:gw-5074|FD-Score:5.27|P-value:9.74E-6 ID:SGTC_543|Compound:3844-1095|FD-Score:8.91|P-value:2.56E-13 ID:SGTC_562|Compound:3772-2733|FD-Score:9.38|P-value:1.43E-14 ID:SGTC_614|Compound:0462-0418|FD-Score:4.07|P-value:5.00E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:7.64|P-value:2.93E-10 ID:SGTC_642|Compound:0335-0876|FD-Score:11.10|P-value:8.34E-20 ID:SGTC_658|Compound:3253-0951|FD-Score:4.90|P-value:3.58E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:6.42|P-value:1.01E-7 ID:SGTC_683|Compound:panaxydol|FD-Score:5.70|P-value:1.96E-6 ID:SGTC_730|Compound:1436-0052|FD-Score:4.05|P-value:5.31E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:4.28|P-value:2.70E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:10.50|P-value:1.02E-17 ID:SGTC_804|Compound:1595-0054|FD-Score:4.39|P-value:1.90E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:6.04|P-value:5.00E-7 ID:SGTC_846|Compound:0335-0850|FD-Score:11.10|P-value:1.26E-19 ID:SGTC_852|Compound:0418-0143|FD-Score:13.30|P-value:1.77E-27 ID:SGTC_863|Compound:0466-0191|FD-Score:10.10|P-value:1.19E-16 ID:SGTC_878|Compound:0828-0289|FD-Score:4.12|P-value:4.24E-4 ID:SGTC_889|Compound:0919-1524|FD-Score:3.88|P-value:8.56E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.84|P-value:9.52E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.96|P-value:6.85E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:7.52|P-value:5.50E-10 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.35|P-value:1.33E-7 ID:SGTC_1347|Compound:1493-0251|FD-Score:5.20|P-value:1.29E-5 ID:SGTC_1359|Compound:1582-0056|FD-Score:-4.16|P-value:3.53E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:5.49|P-value:4.34E-6 ID:SGTC_1386|Compound:3228-0095|FD-Score:4.69|P-value:7.42E-5 ID:SGTC_1446|Compound:4239-0190|FD-Score:7.44|P-value:8.42E-10 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.90|P-value:3.67E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.71|P-value:6.92E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.40|P-value:1.83E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.02|P-value:2.44E-5 ID:SGTC_1658|Compound:st012944|FD-Score:-5.02|P-value:2.16E-5 ID:SGTC_1687|Compound:st020778|FD-Score:14.50|P-value:2.10E-32 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.19|P-value:2.62E-7 ID:SGTC_1877|Compound:wortmannin|FD-Score:4.86|P-value:4.20E-5 ID:SGTC_1941|Compound:st076221|FD-Score:5.16|P-value:1.47E-5 ID:SGTC_1994|Compound:st072947|FD-Score:4.03|P-value:5.58E-4 ID:SGTC_2053|Compound:5265679|FD-Score:4.91|P-value:3.54E-5 ID:SGTC_2060|Compound:5238662|FD-Score:-3.88|P-value:7.90E-4 ID:SGTC_2077|Compound:5212015|FD-Score:8.24|P-value:1.23E-11 ID:SGTC_2200|Compound:6600604|FD-Score:4.27|P-value:2.78E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-4.67|P-value:7.12E-5 ID:SGTC_2285|Compound:7945142|FD-Score:3.93|P-value:7.30E-4 ID:SGTC_2312|Compound:7706453|FD-Score:4.60|P-value:9.95E-5 ID:SGTC_2322|Compound:7413319|FD-Score:6.16|P-value:3.01E-7 ID:SGTC_2351|Compound:9026858|FD-Score:6.96|P-value:8.46E-9 ID:SGTC_2445|Compound:5742597|FD-Score:4.05|P-value:5.32E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.73|P-value:1.89E-10 ID:SGTC_2720|Compound:fluspirilene|FD-Score:5.27|P-value:9.86E-6 ID:SGTC_2729|Compound:fluphenazine|FD-Score:-7.14|P-value:3.10E-9 ID:SGTC_2740|Compound:felodipine|FD-Score:4.83|P-value:4.62E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:5.57|P-value:3.21E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.90|P-value:6.49E-19 ID:SGTC_2858|Compound:9025781|FD-Score:9.95|P-value:3.50E-16 ID:SGTC_2884|Compound:9058502|FD-Score:4.82|P-value:4.74E-5 ID:SGTC_2896|Compound:9052656|FD-Score:9.76|P-value:1.27E-15 ID:SGTC_2923|Compound:7992654|FD-Score:3.98|P-value:6.50E-4 ID:SGTC_2955|Compound:9076254|FD-Score:5.02|P-value:2.43E-5 ID:SGTC_2966|Compound:9084041|FD-Score:4.94|P-value:3.17E-5 ID:SGTC_2988|Compound:9073640|FD-Score:3.89|P-value:8.29E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.52|P-value:1.28E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-5.15|P-value:1.37E-5 ID:SGTC_3056|Compound:9094900|FD-Score:-4.35|P-value:1.96E-4 ID:SGTC_3098|Compound:9119039|FD-Score:5.36|P-value:7.18E-6 ID:SGTC_3263|Compound:9137018|FD-Score:4.61|P-value:9.64E-5 ID:SGTC_3326|Compound:9140064|FD-Score:-4.16|P-value:3.53E-4 ID:SGTC_3330|Compound:9141424|FD-Score:6.06|P-value:4.63E-7 ID:SGTC_3334|Compound:9142812|FD-Score:5.41|P-value:5.98E-6 ID:SGTC_3338|Compound:9144300|FD-Score:5.21|P-value:1.24E-5

Top fitness defect scores for YMR015C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_86 0417-1630 17.00 471.9 µM 1.29E-43 ubiquinone biosynthesis & proteasome 10 3.42E-65
2 SGTC_158 k038-0087 14.60 26.4 µM 1.04E-32 ubiquinone biosynthesis & proteasome 12 1.15E-48
3 SGTC_1687 st020778 14.50 55.4 µM 2.10E-32 24 3.33E-48
4 SGTC_43 0570-0105 13.80 72.5 µM 1.70E-29 ERG2 3 8.50E-44
5 SGTC_852 0418-0143 13.30 439.0 µM 1.77E-27 calcium & mitochondrial duress 6 9.65E-41
6 SGTC_642 0335-0876 11.10 158.0 µM 8.34E-20 ubiquinone biosynthesis & proteasome 5 3.99E-29
7 SGTC_846 0335-0850 11.10 148.0 µM 1.26E-19 ubiquinone biosynthesis & proteasome 1 7.47E-29
8 SGTC_2752 diclazuril 10.90 33.1 µM 6.49E-19 21 8.89E-28
9 SGTC_794 k038-0031 10.50 316.0 µM 1.02E-17 ubiquinone biosynthesis & proteasome 13 5.73E-26
10 SGTC_367 0335-0881 10.40 7.1 µM 2.14E-17 ubiquinone biosynthesis & proteasome 5 1.76E-25
11 SGTC_863 0466-0191 10.10 129.0 µM 1.19E-16 cell wall 11 2.35E-24
12 SGTC_142 0335-0849 10.00 62.7 µM 1.90E-16 ubiquinone biosynthesis & proteasome 29 4.76E-24
13 SGTC_488 nitrendipine 10.00 139.0 µM 2.47E-16 2 7.09E-24
14 SGTC_146 3448-8650 9.97 53.1 µM 3.18E-16 NEO1-PIK1 18 1.04E-23
15 SGTC_2858 9025781 9.95 9.0 µM 3.50E-16 sphingolipid biosynthesis & PDR1 22 1.20E-23
16 SGTC_2896 9052656 9.76 71.4 µM 1.27E-15 endomembrane recycling 9 8.44E-23
17 SGTC_562 3772-2733 9.38 112.0 µM 1.43E-14 ERG2 11 3.27E-21
18 SGTC_543 3844-1095 8.91 191.0 µM 2.56E-13 ERG2 6 2.56E-19
19 SGTC_351 caspofungin 8.50 25.0 nM 2.85E-12 cell wall 13 9.73E-18
20 SGTC_187 1488-2104 8.47 32.7 µM 3.36E-12 calcium & mitochondrial duress 7 1.25E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.397 5.03E-127 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.386 1.71E-119 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.357 3.07E-101 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.350 2.16E-97 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.340 8.53E-92 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.338 2.32E-90 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.327 1.41E-84 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.327 2.49E-84 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.324 6.21E-83 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.305 4.55E-73 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.299 4.65E-70 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.295 1.70E-68 YLR202C_d YLR202C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.285 6.03E-64 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.284 1.62E-63 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.284 3.17E-63 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder