YMR016C / SOK2

Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR016C / SOK2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:4.51|P-value:5.47E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:6.31|P-value:6.54E-14 ID:SGTC_348|Compound:k064-0012|FD-Score:2.90|P-value:3.08E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.04|P-value:2.22E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.31|P-value:4.68E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.02|P-value:1.83E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-2.77|P-value:6.98E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.41|P-value:4.01E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.79|P-value:6.41E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:2.80|P-value:4.77E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.03|P-value:1.76E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.03|P-value:2.36E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.11|P-value:1.20E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.15|P-value:1.02E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.74|P-value:6.09E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.67|P-value:1.08E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.07|P-value:1.47E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.68|P-value:7.07E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.66|P-value:8.22E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.67|P-value:1.91E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.71|P-value:9.02E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.29|P-value:5.08E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.51|P-value:2.46E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.75|P-value:5.69E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:1.75E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.09|P-value:7.21E-7 ID:SGTC_1633|Compound:st005664|FD-Score:3.10|P-value:1.25E-4 ID:SGTC_1709|Compound:st033179|FD-Score:2.86|P-value:3.70E-4 ID:SGTC_1950|Compound:st077106|FD-Score:2.63|P-value:9.31E-4 ID:SGTC_2108|Compound:5365811|FD-Score:4.55|P-value:4.46E-8 ID:SGTC_2110|Compound:5483698|FD-Score:-3.69|P-value:9.83E-6 ID:SGTC_2120|Compound:5538279|FD-Score:-3.82|P-value:4.86E-6 ID:SGTC_2124|Compound:5246320|FD-Score:-5.01|P-value:3.13E-9 ID:SGTC_2184|Compound:6075246|FD-Score:2.73|P-value:6.36E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.57|P-value:1.26E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-2.89|P-value:4.18E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-2.99|P-value:2.76E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.30|P-value:2.06E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.00|P-value:1.98E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-2.69|P-value:9.64E-4 ID:SGTC_3034|Compound:9090421|FD-Score:2.73|P-value:6.29E-4 ID:SGTC_3202|Compound:9113761|FD-Score:2.78|P-value:5.09E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.82|P-value:5.59E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.51|P-value:5.47E-8 ID:SGTC_210|Compound:3551-0445|FD-Score:6.31|P-value:6.54E-14 ID:SGTC_348|Compound:k064-0012|FD-Score:2.90|P-value:3.08E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.04|P-value:2.22E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.31|P-value:4.68E-5 ID:SGTC_398|Compound:bronopol|FD-Score:3.02|P-value:1.83E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-2.77|P-value:6.98E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.41|P-value:4.01E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-2.79|P-value:6.41E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:2.80|P-value:4.77E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.03|P-value:1.76E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:-3.03|P-value:2.36E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.11|P-value:1.20E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.15|P-value:1.02E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:2.74|P-value:6.09E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.67|P-value:1.08E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.07|P-value:1.47E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.68|P-value:7.07E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.66|P-value:8.22E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.67|P-value:1.91E-8 ID:SGTC_1250|Compound:0485-0349|FD-Score:-2.71|P-value:9.02E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.29|P-value:5.08E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.51|P-value:2.46E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:2.75|P-value:5.69E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.51|P-value:1.75E-5 ID:SGTC_1616|Compound:st002734|FD-Score:4.09|P-value:7.21E-7 ID:SGTC_1633|Compound:st005664|FD-Score:3.10|P-value:1.25E-4 ID:SGTC_1709|Compound:st033179|FD-Score:2.86|P-value:3.70E-4 ID:SGTC_1950|Compound:st077106|FD-Score:2.63|P-value:9.31E-4 ID:SGTC_2108|Compound:5365811|FD-Score:4.55|P-value:4.46E-8 ID:SGTC_2110|Compound:5483698|FD-Score:-3.69|P-value:9.83E-6 ID:SGTC_2120|Compound:5538279|FD-Score:-3.82|P-value:4.86E-6 ID:SGTC_2124|Compound:5246320|FD-Score:-5.01|P-value:3.13E-9 ID:SGTC_2184|Compound:6075246|FD-Score:2.73|P-value:6.36E-4 ID:SGTC_2248|Compound:tofa|FD-Score:3.57|P-value:1.26E-5 ID:SGTC_2394|Compound:5221648|FD-Score:-2.89|P-value:4.18E-4 ID:SGTC_2403|Compound:6032726|FD-Score:-2.99|P-value:2.76E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.30|P-value:2.06E-7 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.00|P-value:1.98E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-2.69|P-value:9.64E-4 ID:SGTC_3034|Compound:9090421|FD-Score:2.73|P-value:6.29E-4 ID:SGTC_3202|Compound:9113761|FD-Score:2.78|P-value:5.09E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.82|P-value:5.59E-4

Top fitness defect scores for YMR016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_210 3551-0445 6.31 56.8 µM 6.54E-14 22 1.42E-10
2 SGTC_1248 0469-0687 4.67 58.6 µM 1.91E-8 13 1.47E-6
3 SGTC_2108 5365811 4.55 200.0 µM 4.46E-8 5 2.74E-6
4 SGTC_21 0849-0113 4.51 23.0 µM 5.47E-8 22 3.18E-6
5 SGTC_2584 androsterone 4.30 48.7 µM 2.06E-7 cell wall 108 8.47E-6
6 SGTC_1616 st002734 4.09 56.1 µM 7.21E-7 26 2.13E-5
7 SGTC_1119 parthenolide 3.68 318.5 nM 7.07E-6 TSC3-RPN4 47 1.15E-4
8 SGTC_2248 tofa 3.57 1.1 µM 1.26E-5 sphingolipid biosynthesis & PDR1 50 1.76E-4
9 SGTC_1602 st001878 3.51 87.6 µM 1.75E-5 30 2.24E-4
10 SGTC_367 0335-0881 3.31 7.1 µM 4.68E-5 ubiquinone biosynthesis & proteasome 120 4.64E-4
11 SGTC_1371 2421-0008 3.29 32.7 µM 5.08E-5 mitochondrial processes 70 4.93E-4
12 SGTC_905 2-aminofluorene 3.15 215.0 µM 1.02E-4 cell wall signaling 60 8.27E-4
13 SGTC_855 0428-0020 3.11 25.0 µM 1.20E-4 Golgi 49 9.29E-4
14 SGTC_1633 st005664 3.10 67.9 µM 1.25E-4 80 9.61E-4
15 SGTC_1116 jasmonic acid 3.07 1.6 µM 1.47E-4 53 0.00108
16 SGTC_830 4076-0286 3.03 57.8 µM 1.76E-4 translation 140 0.00124
17 SGTC_398 bronopol 3.02 33.3 µM 1.83E-4 RNA processing & uracil transport 62 0.00128
18 SGTC_2638 epoxomicin 3.00 18.0 µM 1.98E-4 69 0.00135
19 SGTC_348 k064-0012 2.90 10.7 µM 3.08E-4 60S ribosome export 61 0.00188
20 SGTC_1709 st033179 2.86 39.1 µM 3.70E-4 66 0.00215

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.26E-16 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.140 3.82E-16 YLR102C APC9 hom Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.136 2.12E-15 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.132 1.47E-14 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.128 1.13E-13 YML006C GIS4 hom CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
0.121 2.03E-12 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.118 7.21E-12 YLR243W GPN3 het Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
0.117 1.25E-11 YLR403W SFP1 hom Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion
0.114 3.35E-11 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.112 7.50E-11 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.110 2.25E-10 YHR163W SOL3 hom 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication
0.109 2.85E-10 YAL011W SWC3 hom Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae
0.106 6.23E-10 YNR012W URK1 hom Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
0.106 7.17E-10 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.106 7.19E-10 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication