YMR017W / SPO20

Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR017W / SPO20

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.21|P-value:1.92E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.48|P-value:7.87E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.38|P-value:9.22E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:2.92|P-value:6.31E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.31|P-value:1.01E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:3.02|P-value:4.24E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.08|P-value:3.33E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.87|P-value:7.54E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.29|P-value:1.39E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.45|P-value:8.81E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.52|P-value:5.10E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.97|P-value:5.80E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.88|P-value:9.31E-6 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.08|P-value:3.31E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:2.80|P-value:9.57E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.86|P-value:1.00E-5 ID:SGTC_1683|Compound:st010134|FD-Score:2.91|P-value:6.41E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.86|P-value:1.01E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.22|P-value:1.90E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.51|P-value:5.31E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.43|P-value:7.59E-5 ID:SGTC_2155|Compound:5570423|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.01|P-value:4.35E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.00|P-value:4.56E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:2.83|P-value:8.69E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.48|P-value:6.03E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.69|P-value:1.61E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.60|P-value:3.56E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.27|P-value:1.70E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.53|P-value:4.88E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.41|P-value:1.06E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:13.00|P-value:2.44E-46 ID:SGTC_2703|Compound:st077852|FD-Score:-3.22|P-value:2.38E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.88|P-value:9.41E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.70|P-value:2.89E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.36|P-value:1.04E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:2.80|P-value:9.82E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.37|P-value:1.00E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.02|P-value:4.14E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-4.60|P-value:2.70E-7 ID:SGTC_2834|Compound:9001755|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-2.93|P-value:7.24E-4 ID:SGTC_2927|Compound:9011802|FD-Score:2.83|P-value:8.63E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-2.96|P-value:6.59E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.42|P-value:7.85E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.06|P-value:4.47E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.27|P-value:1.50E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:3.21|P-value:1.92E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.48|P-value:7.87E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:-4.38|P-value:9.22E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:2.92|P-value:6.31E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:4.31|P-value:1.01E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:3.02|P-value:4.24E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:4.08|P-value:3.33E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.87|P-value:7.54E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.29|P-value:1.39E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:-3.45|P-value:8.81E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.52|P-value:5.10E-5 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.97|P-value:5.80E-6 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.88|P-value:9.31E-6 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.08|P-value:3.31E-4 ID:SGTC_1481|Compound:3346-2004|FD-Score:2.80|P-value:9.57E-4 ID:SGTC_1672|Compound:st016598|FD-Score:3.86|P-value:1.00E-5 ID:SGTC_1683|Compound:st010134|FD-Score:2.91|P-value:6.41E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.86|P-value:1.01E-5 ID:SGTC_1995|Compound:st072814|FD-Score:3.22|P-value:1.90E-4 ID:SGTC_2031|Compound:5180455|FD-Score:3.51|P-value:5.31E-5 ID:SGTC_2036|Compound:5160441|FD-Score:3.43|P-value:7.59E-5 ID:SGTC_2155|Compound:5570423|FD-Score:3.12|P-value:2.84E-4 ID:SGTC_2311|Compound:7694451|FD-Score:3.01|P-value:4.35E-4 ID:SGTC_2377|Compound:9073351|FD-Score:3.00|P-value:4.56E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:2.83|P-value:8.69E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.48|P-value:6.03E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.69|P-value:1.61E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.60|P-value:3.56E-5 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-4.27|P-value:1.70E-6 ID:SGTC_2575|Compound:plumbagin|FD-Score:3.53|P-value:4.88E-5 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.41|P-value:1.06E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:13.00|P-value:2.44E-46 ID:SGTC_2703|Compound:st077852|FD-Score:-3.22|P-value:2.38E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.88|P-value:9.41E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:-3.70|P-value:2.89E-5 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.36|P-value:1.04E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:2.80|P-value:9.82E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.37|P-value:1.00E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.02|P-value:4.14E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-4.60|P-value:2.70E-7 ID:SGTC_2834|Compound:9001755|FD-Score:3.19|P-value:2.14E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-2.93|P-value:7.24E-4 ID:SGTC_2927|Compound:9011802|FD-Score:2.83|P-value:8.63E-4 ID:SGTC_3055|Compound:9094636|FD-Score:-2.96|P-value:6.59E-4 ID:SGTC_3118|Compound:9124250|FD-Score:3.42|P-value:7.85E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-3.06|P-value:4.47E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.27|P-value:1.50E-4

Top fitness defect scores for YMR017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2596 sinensetin 13.00 100.0 µM 2.44E-46 1 8.58E-39
2 SGTC_730 1436-0052 4.31 41.2 µM 1.01E-6 mitochondrial processes 7 8.20E-6
3 SGTC_921 1561-0023 4.08 372.0 µM 3.33E-6 15 2.22E-5
4 SGTC_1416 3966-0321 3.97 25.3 µM 5.80E-6 14 3.52E-5
5 SGTC_1422 4031-0024 3.88 15.5 µM 9.31E-6 iron homeostasis 20 5.23E-5
6 SGTC_2754 granisetron 3.88 64.0 µM 9.41E-6 32 5.28E-5
7 SGTC_1672 st016598 3.86 6.5 µM 1.00E-5 endomembrane recycling 70 5.56E-5
8 SGTC_1944 st076371 3.86 56.9 µM 1.01E-5 23 5.61E-5
9 SGTC_2562 3',7'-dimethoxyflavone 3.60 64.9 µM 3.56E-5 45 1.60E-4
10 SGTC_2575 plumbagin 3.53 510.0 nM 4.88E-5 superoxide 59 2.09E-4
11 SGTC_1408 3909-7976 3.52 48.8 µM 5.10E-5 Golgi 38 2.16E-4
12 SGTC_2031 5180455 3.51 200.0 µM 5.31E-5 18 2.24E-4
13 SGTC_2540 epiandrosterone 3.48 100.0 µM 6.03E-5 80 2.49E-4
14 SGTC_2036 5160441 3.43 105.0 µM 7.59E-5 NEO1 98 3.02E-4
15 SGTC_3118 9124250 3.42 49.5 µM 7.85E-5 25 3.10E-4
16 SGTC_2784 7567673 3.37 72.7 µM 1.00E-4 iron homeostasis 53 3.81E-4
17 SGTC_2764 methyldopa 3.36 94.7 µM 1.04E-4 34 3.92E-4
18 SGTC_1279 0874-0590 3.29 65.2 µM 1.39E-4 55 5.01E-4
19 SGTC_3271 9137798 3.27 49.5 µM 1.50E-4 20 5.32E-4
20 SGTC_1995 st072814 3.22 61.1 µM 1.90E-4 32 6.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.83E-17 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.138 1.05E-15 YMR090W_p YMR090W_p hom Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability
0.137 1.81E-15 YIR030C DCG1 hom Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
0.130 3.50E-14 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.129 5.44E-14 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.120 2.51E-12 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
0.120 3.12E-12 YJL038C LOH1 hom Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
0.110 1.95E-10 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.103 1.86E-9 YGR246C BRF1 het TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB
0.103 2.19E-9 YOR026W BUB3 hom Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
0.101 3.88E-9 YBR137W YBR137W hom Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene
0.098 1.33E-8 YGL158W RCK1 hom Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication
0.097 1.63E-8 YDR448W ADA2 hom Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
0.093 6.02E-8 YOR144C ELG1 hom Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication
0.090 1.66E-7 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein