YMR020W / FMS1

Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR020W / FMS1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.96|P-value:3.18E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.87|P-value:4.56E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.83|P-value:6.26E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:4.14|P-value:9.09E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.38|P-value:4.72E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.51|P-value:2.58E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.84|P-value:5.95E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.86|P-value:4.71E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.19|P-value:1.15E-4 ID:SGTC_456|Compound:gingerol|FD-Score:2.72|P-value:8.25E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.35|P-value:6.50E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.32|P-value:6.23E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.89|P-value:3.57E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:2.97|P-value:2.99E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.36|P-value:5.32E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.63|P-value:1.39E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.06|P-value:1.76E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.02|P-value:2.45E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-2.87|P-value:5.32E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.38|P-value:4.75E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.85|P-value:4.90E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:2.90|P-value:4.04E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-2.75|P-value:8.69E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.03|P-value:2.35E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.36|P-value:5.26E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.15|P-value:1.61E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:1.92E-5 ID:SGTC_1994|Compound:st072947|FD-Score:2.70|P-value:8.92E-4 ID:SGTC_2015|Compound:5119600|FD-Score:5.24|P-value:7.91E-10 ID:SGTC_2093|Compound:5331342|FD-Score:2.68|P-value:9.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.09|P-value:2.33E-9 ID:SGTC_2195|Compound:6536160|FD-Score:-3.55|P-value:2.53E-5 ID:SGTC_2207|Compound:7258803|FD-Score:3.63|P-value:1.42E-5 ID:SGTC_2337|Compound:9009472|FD-Score:2.84|P-value:5.20E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.99|P-value:2.80E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.62|P-value:1.47E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.33|P-value:2.93E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.03|P-value:2.33E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.45|P-value:3.43E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.70|P-value:1.01E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.06|P-value:2.07E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-2.93|P-value:4.21E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.93|P-value:3.58E-6 ID:SGTC_2837|Compound:9008476|FD-Score:4.21|P-value:6.10E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-3.10|P-value:2.00E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-2.83|P-value:6.16E-4 ID:SGTC_2950|Compound:9072895|FD-Score:8.80|P-value:2.28E-24 ID:SGTC_2970|Compound:9090938|FD-Score:3.82|P-value:5.29E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.18|P-value:1.41E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.41|P-value:1.90E-7 ID:SGTC_3211|Compound:9128781|FD-Score:4.07|P-value:1.35E-6 ID:SGTC_3263|Compound:9137018|FD-Score:2.86|P-value:4.69E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.21|P-value:1.05E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.21|P-value:1.04E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:2.96|P-value:3.18E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.87|P-value:4.56E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.83|P-value:6.26E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:4.14|P-value:9.09E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.38|P-value:4.72E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.51|P-value:2.58E-5 ID:SGTC_396|Compound:dithiazanine|FD-Score:-2.84|P-value:5.95E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:2.86|P-value:4.71E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.19|P-value:1.15E-4 ID:SGTC_456|Compound:gingerol|FD-Score:2.72|P-value:8.25E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.35|P-value:6.50E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:3.32|P-value:6.23E-5 ID:SGTC_827|Compound:3253-0474|FD-Score:3.89|P-value:3.57E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:2.97|P-value:2.99E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.36|P-value:5.32E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.63|P-value:1.39E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.06|P-value:1.76E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.02|P-value:2.45E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-2.87|P-value:5.32E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.38|P-value:4.75E-5 ID:SGTC_1186|Compound:1319-0216|FD-Score:2.85|P-value:4.90E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:2.90|P-value:4.04E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-2.75|P-value:8.69E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.03|P-value:2.35E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:3.36|P-value:5.26E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.15|P-value:1.61E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.60|P-value:1.92E-5 ID:SGTC_1994|Compound:st072947|FD-Score:2.70|P-value:8.92E-4 ID:SGTC_2015|Compound:5119600|FD-Score:5.24|P-value:7.91E-10 ID:SGTC_2093|Compound:5331342|FD-Score:2.68|P-value:9.79E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.09|P-value:2.33E-9 ID:SGTC_2195|Compound:6536160|FD-Score:-3.55|P-value:2.53E-5 ID:SGTC_2207|Compound:7258803|FD-Score:3.63|P-value:1.42E-5 ID:SGTC_2337|Compound:9009472|FD-Score:2.84|P-value:5.20E-4 ID:SGTC_2363|Compound:9053361|FD-Score:2.99|P-value:2.80E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.62|P-value:1.47E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.33|P-value:2.93E-7 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.03|P-value:2.33E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.45|P-value:3.43E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.70|P-value:1.01E-5 ID:SGTC_2623|Compound:humulene|FD-Score:3.06|P-value:2.07E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-2.93|P-value:4.21E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.93|P-value:3.58E-6 ID:SGTC_2837|Compound:9008476|FD-Score:4.21|P-value:6.10E-7 ID:SGTC_2908|Compound:7930301|FD-Score:-3.10|P-value:2.00E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-2.83|P-value:6.16E-4 ID:SGTC_2950|Compound:9072895|FD-Score:8.80|P-value:2.28E-24 ID:SGTC_2970|Compound:9090938|FD-Score:3.82|P-value:5.29E-6 ID:SGTC_3028|Compound:9087778|FD-Score:-3.18|P-value:1.41E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.41|P-value:1.90E-7 ID:SGTC_3211|Compound:9128781|FD-Score:4.07|P-value:1.35E-6 ID:SGTC_3263|Compound:9137018|FD-Score:2.86|P-value:4.69E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.21|P-value:1.05E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.21|P-value:1.04E-4

Top fitness defect scores for YMR020W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2950 9072895 8.80 21.5 µM 2.28E-24 1 7.01E-19
2 SGTC_2015 5119600 5.24 184.0 µM 7.91E-10 12 8.02E-8
3 SGTC_2125 5246583 5.09 200.0 µM 2.33E-9 tubulin folding & SWR complex 24 1.83E-7
4 SGTC_3210 9128157 4.41 49.5 µM 1.90E-7 36 5.26E-6
5 SGTC_2409 alverine citrate 4.33 64.0 µM 2.93E-7 45 7.32E-6
6 SGTC_2837 9008476 4.21 45.5 µM 6.10E-7 28 1.28E-5
7 SGTC_357 1325-0123 4.14 420.0 µM 9.09E-7 5 1.74E-5
8 SGTC_3211 9128781 4.07 49.5 µM 1.35E-6 54 2.35E-5
9 SGTC_827 3253-0474 3.89 693.0 µM 3.57E-6 20 4.94E-5
10 SGTC_2970 9090938 3.82 41.9 µM 5.29E-6 RNA processing & uracil transport 42 6.68E-5
11 SGTC_2603 homopterocarpin 3.70 100.0 µM 1.01E-5 54 1.10E-4
12 SGTC_1096 rimcazole 3.63 32.2 µM 1.39E-5 17 1.40E-4
13 SGTC_2207 7258803 3.63 200.0 µM 1.42E-5 11 1.42E-4
14 SGTC_2402 5553605 3.62 200.0 µM 1.47E-5 41 1.47E-4
15 SGTC_367 0335-0881 3.51 7.1 µM 2.58E-5 ubiquinone biosynthesis & proteasome 99 2.25E-4
16 SGTC_2595 hexamethylquercetagetin 3.45 100.0 µM 3.43E-5 44 2.80E-4
17 SGTC_366 0181-0206 3.38 4.3 µM 4.72E-5 Golgi 69 3.58E-4
18 SGTC_1179 1021-1431 3.38 9.3 µM 4.75E-5 69 3.59E-4
19 SGTC_1335 1486-0900 3.36 202.0 µM 5.26E-5 53 3.89E-4
20 SGTC_1048 3161-0300 3.36 24.5 µM 5.32E-5 37 3.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 3.12E-21 YHR121W LSM12 hom Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress
0.158 3.37E-20 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.157 7.47E-20 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.156 1.07E-19 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.154 3.02E-19 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.151 1.33E-18 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.149 3.46E-18 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.139 7.71E-16 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.138 8.65E-16 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.138 1.03E-15 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.134 6.61E-15 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.133 1.14E-14 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.133 1.33E-14 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.131 3.17E-14 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.130 4.46E-14 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS