HIPHOP chemogenomics database
YMR021C / MAC1 
Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR021C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.422 | 5.70E-145 | YPR124W | CTR1 | hom | High-affinity copper transporter of the plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress |
| 0.416 | 1.22E-140 | YPR123C_d | YPR123C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR |
| 0.292 | 9.63E-67 | YMR038C | CCS1 | hom | Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; protein abundance increases in response to DNA replication stress |
| 0.263 | 5.69E-54 | YJR104C | SOD1 | hom | Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid |
| 0.215 | 2.58E-36 | YGL167C | PMR1 | hom | High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease |
| 0.185 | 3.18E-27 | YHR008C | SOD2 | hom | Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated |
| 0.162 | 3.28E-21 | YGL168W | HUR1 | hom | Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene |
| 0.150 | 2.78E-18 | YPR074C | TKL1 | hom | Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication |
| 0.136 | 2.06E-15 | YNL241C | ZWF1 | hom | Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia; protein abundance increases in response to DNA replication stress |
| 0.132 | 1.39E-14 | YGL071W | AFT1 | hom | Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions activity is negatively regulated by Grx3p, Grx4p, and Fra2p, which regulate Aft1p translocation from the nucleus to the cytoplasm; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress |
| 0.124 | 5.49E-13 | YJL120W_d | YJL120W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO |
| 0.124 | 6.85E-13 | YLR044C | PDC1 | hom | Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism |
| 0.118 | 7.54E-12 | YJR102C | VPS25 | hom | Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome |
| 0.117 | 1.19E-11 | YOR323C | PRO2 | hom | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
| 0.114 | 3.58E-11 | YDR271C_d | YDR271C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W |