YMR022W / UBC7

Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR022W / UBC7

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:7.08|P-value:2.53E-11 ID:SGTC_7|Compound:0192-1582|FD-Score:6.36|P-value:1.83E-9 ID:SGTC_12|Compound:0849-0099|FD-Score:4.82|P-value:4.00E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:17.30|P-value:1.91E-58 ID:SGTC_18|Compound:0111-0177|FD-Score:5.50|P-value:1.69E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.34|P-value:2.12E-9 ID:SGTC_55|Compound:0767-0285|FD-Score:3.68|P-value:3.36E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.37|P-value:2.18E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:41.10|P-value:0 ID:SGTC_86|Compound:0417-1630|FD-Score:10.40|P-value:2.69E-22 ID:SGTC_103|Compound:0844-0104|FD-Score:20.80|P-value:1.44E-83 ID:SGTC_137|Compound:0438-0332|FD-Score:17.90|P-value:3.50E-62 ID:SGTC_142|Compound:0335-0849|FD-Score:5.91|P-value:2.12E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:3.98|P-value:1.14E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:5.23|P-value:6.43E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:4.78|P-value:4.85E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:4.38|P-value:2.55E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:5.59|P-value:1.11E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.50|P-value:1.29E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.95|P-value:6.01E-14 ID:SGTC_315|Compound:k915-0449|FD-Score:9.34|P-value:2.15E-18 ID:SGTC_332|Compound:4112-0506|FD-Score:3.88|P-value:1.68E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:5.59|P-value:1.13E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:17.00|P-value:3.34E-56 ID:SGTC_367|Compound:0335-0881|FD-Score:4.25|P-value:4.17E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:17.50|P-value:1.31E-59 ID:SGTC_384|Compound:k007-0144|FD-Score:17.80|P-value:7.17E-62 ID:SGTC_426|Compound:0988-0037|FD-Score:19.60|P-value:2.72E-74 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.40|P-value:1.51E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:7.14|P-value:1.81E-11 ID:SGTC_547|Compound:1120-0019|FD-Score:3.38|P-value:9.05E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:11.30|P-value:5.04E-26 ID:SGTC_575|Compound:k072-0246|FD-Score:3.96|P-value:1.24E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.93|P-value:2.49E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:27.00|P-value:3.33E-139 ID:SGTC_640|Compound:3381-0960|FD-Score:4.36|P-value:2.73E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.18|P-value:5.51E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.13|P-value:6.65E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:20.30|P-value:2.24E-79 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.96|P-value:1.06E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.92|P-value:2.62E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:3.79|P-value:2.30E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.12|P-value:6.84E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.45|P-value:1.94E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.56|P-value:4.95E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.71|P-value:2.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.18|P-value:5.46E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.59|P-value:4.53E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:18.50|P-value:2.34E-66 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.07|P-value:7.03E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:19.60|P-value:3.68E-74 ID:SGTC_1165|Compound:k072-0275|FD-Score:6.05|P-value:1.01E-8 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.40|P-value:8.43E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.46|P-value:5.93E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.91|P-value:1.51E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.57|P-value:4.83E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.58|P-value:4.61E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.87|P-value:3.28E-6 ID:SGTC_1884|Compound:5633444|FD-Score:3.60|P-value:4.39E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.32|P-value:3.15E-5 ID:SGTC_2157|Compound:5649910|FD-Score:4.00|P-value:1.06E-4 ID:SGTC_2163|Compound:5671233|FD-Score:5.04|P-value:1.55E-6 ID:SGTC_2322|Compound:7413319|FD-Score:7.08|P-value:2.65E-11 ID:SGTC_2364|Compound:9055074|FD-Score:8.36|P-value:4.38E-15 ID:SGTC_2385|Compound:9074692|FD-Score:4.78|P-value:4.79E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:11.60|P-value:3.35E-27 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.50|P-value:5.27E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.32|P-value:9.43E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.39|P-value:8.68E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.35|P-value:9.92E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.59|P-value:3.87E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.33|P-value:8.92E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.17|P-value:5.65E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:7.08|P-value:2.53E-11 ID:SGTC_7|Compound:0192-1582|FD-Score:6.36|P-value:1.83E-9 ID:SGTC_12|Compound:0849-0099|FD-Score:4.82|P-value:4.00E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:17.30|P-value:1.91E-58 ID:SGTC_18|Compound:0111-0177|FD-Score:5.50|P-value:1.69E-7 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:6.34|P-value:2.12E-9 ID:SGTC_55|Compound:0767-0285|FD-Score:3.68|P-value:3.36E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.37|P-value:2.18E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:41.10|P-value:0 ID:SGTC_86|Compound:0417-1630|FD-Score:10.40|P-value:2.69E-22 ID:SGTC_103|Compound:0844-0104|FD-Score:20.80|P-value:1.44E-83 ID:SGTC_137|Compound:0438-0332|FD-Score:17.90|P-value:3.50E-62 ID:SGTC_142|Compound:0335-0849|FD-Score:5.91|P-value:2.12E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:3.98|P-value:1.14E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:5.23|P-value:6.43E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:4.78|P-value:4.85E-6 ID:SGTC_192|Compound:3455-0609|FD-Score:4.38|P-value:2.55E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:5.59|P-value:1.11E-7 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.50|P-value:1.29E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-7.95|P-value:6.01E-14 ID:SGTC_315|Compound:k915-0449|FD-Score:9.34|P-value:2.15E-18 ID:SGTC_332|Compound:4112-0506|FD-Score:3.88|P-value:1.68E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:5.59|P-value:1.13E-7 ID:SGTC_352|Compound:k048-0007|FD-Score:17.00|P-value:3.34E-56 ID:SGTC_367|Compound:0335-0881|FD-Score:4.25|P-value:4.17E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:17.50|P-value:1.31E-59 ID:SGTC_384|Compound:k007-0144|FD-Score:17.80|P-value:7.17E-62 ID:SGTC_426|Compound:0988-0037|FD-Score:19.60|P-value:2.72E-74 ID:SGTC_450|Compound:aminopyrene|FD-Score:6.40|P-value:1.51E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:7.14|P-value:1.81E-11 ID:SGTC_547|Compound:1120-0019|FD-Score:3.38|P-value:9.05E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:11.30|P-value:5.04E-26 ID:SGTC_575|Compound:k072-0246|FD-Score:3.96|P-value:1.24E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:4.93|P-value:2.49E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:27.00|P-value:3.33E-139 ID:SGTC_640|Compound:3381-0960|FD-Score:4.36|P-value:2.73E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.18|P-value:5.51E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:4.13|P-value:6.65E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:20.30|P-value:2.24E-79 ID:SGTC_766|Compound:1391-0721|FD-Score:-3.96|P-value:1.06E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.92|P-value:2.62E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:3.79|P-value:2.30E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.12|P-value:6.84E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.45|P-value:1.94E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.56|P-value:4.95E-4 ID:SGTC_982|Compound:1491-0518|FD-Score:3.71|P-value:2.98E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:4.18|P-value:5.46E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.59|P-value:4.53E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:18.50|P-value:2.34E-66 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.07|P-value:7.03E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:19.60|P-value:3.68E-74 ID:SGTC_1165|Compound:k072-0275|FD-Score:6.05|P-value:1.01E-8 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.40|P-value:8.43E-4 ID:SGTC_1668|Compound:st014914|FD-Score:-3.46|P-value:5.93E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.91|P-value:1.51E-4 ID:SGTC_1763|Compound:st044482|FD-Score:3.57|P-value:4.83E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.58|P-value:4.61E-4 ID:SGTC_1842|Compound:st055362|FD-Score:4.87|P-value:3.28E-6 ID:SGTC_1884|Compound:5633444|FD-Score:3.60|P-value:4.39E-4 ID:SGTC_2154|Compound:5570129|FD-Score:4.32|P-value:3.15E-5 ID:SGTC_2157|Compound:5649910|FD-Score:4.00|P-value:1.06E-4 ID:SGTC_2163|Compound:5671233|FD-Score:5.04|P-value:1.55E-6 ID:SGTC_2322|Compound:7413319|FD-Score:7.08|P-value:2.65E-11 ID:SGTC_2364|Compound:9055074|FD-Score:8.36|P-value:4.38E-15 ID:SGTC_2385|Compound:9074692|FD-Score:4.78|P-value:4.79E-6 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:11.60|P-value:3.35E-27 ID:SGTC_2638|Compound:epoxomicin|FD-Score:-3.50|P-value:5.27E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.32|P-value:9.43E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:3.39|P-value:8.68E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.35|P-value:9.92E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.59|P-value:3.87E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.33|P-value:8.92E-4 ID:SGTC_2918|Compound:7977171|FD-Score:4.17|P-value:5.65E-5

Top fitness defect scores for YMR022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 41.10 272.1 µM 0 ubiquinone biosynthesis & proteasome 2 0
2 SGTC_637 1181-0519 27.00 7.3 µM 3.33E-139 fatty acid desaturase (OLE1) 1 1.15E-160
3 SGTC_103 0844-0104 20.80 51.8 µM 1.44E-83 ERAD & cell cycle 3 2.25E-96
4 SGTC_733 4069-0007 20.30 56.1 µM 2.24E-79 ERAD & cell cycle 3 1.57E-91
5 SGTC_426 0988-0037 19.60 14.6 µM 2.72E-74 ERAD & cell cycle 1 1.18E-85
6 SGTC_1161 k007-0610 19.60 110.0 µM 3.68E-74 ERAD & cell cycle 2 1.68E-85
7 SGTC_1026 k007-1105 18.50 30.6 µM 2.34E-66 ERAD & cell cycle 3 1.75E-76
8 SGTC_137 0438-0332 17.90 85.4 µM 3.50E-62 ubiquinone biosynthesis & proteasome 7 1.17E-71
9 SGTC_384 k007-0144 17.80 5.2 µM 7.17E-62 ERAD & cell cycle 3 2.68E-71
10 SGTC_373 0844-0104 17.50 25.9 µM 1.31E-59 ERAD & cell cycle 2 1.10E-68
11 SGTC_16 erodoxin 17.30 22.8 µM 1.91E-58 unfolded protein response 6 2.44E-67
12 SGTC_352 k048-0007 17.00 5.1 µM 3.34E-56 ERAD & cell cycle 1 9.53E-65
13 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 11.60 3.7 µM 3.35E-27 1 3.16E-31
14 SGTC_568 1193-0097 11.30 7.5 µM 5.04E-26 ERAD & cell cycle 16 7.23E-30
15 SGTC_86 0417-1630 10.40 471.9 µM 2.69E-22 ubiquinone biosynthesis & proteasome 36 1.47E-25
16 SGTC_315 k915-0449 9.34 187.0 µM 2.15E-18 8 4.75E-21
17 SGTC_2364 9055074 8.36 200.0 µM 4.38E-15 1 3.18E-17
18 SGTC_513 4245-1575 7.14 41.7 µM 1.81E-11 unfolded protein response 32 4.79E-13
19 SGTC_6 0844-0013 7.08 19.8 µM 2.53E-11 4 7.04E-13
20 SGTC_2322 7413319 7.08 38.2 µM 2.65E-11 ERAD & cell cycle 47 7.44E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.659 0 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.545 5.61E-259 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.530 4.65E-243 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.512 9.48E-224 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.511 5.05E-223 YMR264W CUE1 hom Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication
0.465 2.83E-179 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.458 8.57E-174 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.454 5.26E-170 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.432 3.46E-152 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.410 1.85E-136 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.407 1.19E-133 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.406 9.28E-134 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.378 1.57E-114 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.366 4.73E-107 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.358 4.24E-102 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p