HIPHOP chemogenomics database

YMR029C / FAR8

Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR029C / FAR8

Click on Significant Values for Screen Details

Top fitness defect scores for YMR029C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_103	0844-0104	13.30	51.8 µM	5.04E-46	ERAD & cell cycle	13	1.97E-40
2	SGTC_805	3852-0218	12.40	479.0 µM	1.41E-40	ERAD & cell cycle	2	1.14E-35
3	SGTC_1161	k007-0610	8.87	110.0 µM	1.03E-21	ERAD & cell cycle	19	3.65E-19
4	SGTC_384	k007-0144	6.85	5.2 µM	1.08E-13	ERAD & cell cycle	17	3.80E-12
5	SGTC_1739	st037196	6.23	92.5 µM	1.19E-11		1	2.32E-10
6	SGTC_733	4069-0007	5.92	56.1 µM	1.07E-10	ERAD & cell cycle	41	1.60E-9
7	SGTC_2397	5161689	5.73	200.0 µM	4.02E-10		7	5.07E-9
8	SGTC_2426	5582046	5.57	32.2 µM	1.12E-9		6	1.25E-8
9	SGTC_352	k048-0007	5.25	5.1 µM	8.86E-9	ERAD & cell cycle	43	7.60E-8
10	SGTC_3141	9094609	5.22	49.5 µM	1.06E-8	iron homeostasis	16	8.88E-8
11	SGTC_2790	5423970	5.22	71.4 µM	1.08E-8	endomembrane recycling	35	9.08E-8
12	SGTC_1257	0669-0121	5.17	16.0 µM	1.41E-8		10	1.14E-7
13	SGTC_1026	k007-1105	4.96	30.6 µM	5.01E-8	ERAD & cell cycle	60	3.47E-7
14	SGTC_373	0844-0104	4.84	25.9 µM	1.03E-7	ERAD & cell cycle	33	6.52E-7
15	SGTC_1725	st036284	4.58	20.6 µM	4.29E-7		21	2.27E-6
16	SGTC_3263	9137018	4.53	49.5 µM	5.65E-7		9	2.90E-6
17	SGTC_568	1193-0097	4.42	7.5 µM	1.05E-6	ERAD & cell cycle	118	5.00E-6
18	SGTC_2724	maprotiline	4.36	69.6 µM	1.39E-6	ERG2	6	6.38E-6
19	SGTC_1750	st081859	4.19	2.4 µM	3.42E-6	endomembrane recycling	168	1.41E-5
20	SGTC_3214	9129694	4.12	49.5 µM	4.76E-6		24	1.88E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.472	7.92E-186	YIL030C	SSM4	hom	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.465	9.10E-180	YDR186C	YDR186C	hom	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.454	1.60E-170	YER084W_p	YER084W_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.441	6.06E-160	YOL002C	IZH2	hom	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.434	6.27E-154	YDR199W_d	YDR199W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.415	2.86E-140	YMR052C-A_d	YMR052C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.388	3.41E-121	YKR014C	YPT52	hom	Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.378	1.62E-114	YDL148C	NOP14	het	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.372	1.29E-110	YMR052W	FAR3	hom	Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.358	4.24E-102	YMR022W	UBC7	hom	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.348	4.48E-96	YFR008W	FAR7	hom	Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.339	4.32E-91	YOR246C	ENV9	hom	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.312	1.39E-76	YMR067C	UBX4	hom	UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.295	1.86E-68	YOL065C	INP54	hom	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.287	9.19E-65	YDR200C	VPS64	hom	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance