YMR031C / EIS1

Component of the eisosome required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR031C / EIS1

Click on Significant Values for Screen Details ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.93|P-value:6.31E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:5.13|P-value:3.22E-7 ID:SGTC_362|Compound:0310-0100|FD-Score:4.21|P-value:2.30E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.47|P-value:3.89E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.75|P-value:1.24E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.43|P-value:4.05E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.69|P-value:1.79E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.95|P-value:6.42E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.46|P-value:4.10E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.27|P-value:7.77E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.66|P-value:1.93E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.45|P-value:3.75E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.76|P-value:1.19E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.96|P-value:7.44E-7 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.11|P-value:3.42E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.66|P-value:1.95E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.62|P-value:2.01E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.23|P-value:2.08E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.66|P-value:1.97E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-4.44|P-value:7.25E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.12|P-value:2.87E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-4.01|P-value:4.53E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-3.97|P-value:5.20E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.45|P-value:3.80E-4 ID:SGTC_2270|Compound:7924575|FD-Score:5.11|P-value:3.57E-7 ID:SGTC_2309|Compound:7664088|FD-Score:-3.78|P-value:1.10E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.24|P-value:8.58E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.96|P-value:6.51E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.27|P-value:6.86E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.41|P-value:4.32E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.75|P-value:1.25E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.46|P-value:3.66E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.73|P-value:1.37E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.42|P-value:4.71E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-4.99|P-value:5.59E-7 ID:SGTC_2944|Compound:9067346|FD-Score:3.22|P-value:9.04E-4 ID:SGTC_2962|Compound:9082311|FD-Score:6.89|P-value:1.11E-11 ID:SGTC_3052|Compound:9092717|FD-Score:3.55|P-value:2.97E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.25|P-value:8.38E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.87|P-value:8.78E-5 ID:SGTC_3262|Compound:9137218|FD-Score:-3.85|P-value:8.50E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.46|P-value:4.11E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.58|P-value:2.32E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.84|P-value:8.69E-5 ID:SGTC_3354|Compound:9151612|FD-Score:-3.17|P-value:9.68E-4 ID:SGTC_247|Compound:mechlorethamine|FD-Score:-3.93|P-value:6.31E-5 ID:SGTC_350|Compound:k064-0020|FD-Score:5.13|P-value:3.22E-7 ID:SGTC_362|Compound:0310-0100|FD-Score:4.21|P-value:2.30E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.47|P-value:3.89E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.75|P-value:1.24E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.43|P-value:4.05E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:3.69|P-value:1.79E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.27|P-value:7.84E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:3.70|P-value:1.72E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.95|P-value:6.42E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.46|P-value:4.10E-4 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.27|P-value:7.77E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.66|P-value:1.93E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.45|P-value:3.75E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:-3.76|P-value:1.19E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:3.21|P-value:9.45E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:4.96|P-value:7.44E-7 ID:SGTC_1550|Compound:gossypolone|FD-Score:4.11|P-value:3.42E-5 ID:SGTC_1555|Compound:citronellol|FD-Score:3.66|P-value:1.95E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.62|P-value:2.01E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.23|P-value:2.08E-5 ID:SGTC_1819|Compound:st053448|FD-Score:3.66|P-value:1.97E-4 ID:SGTC_1924|Compound:st058459|FD-Score:-4.44|P-value:7.25E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.12|P-value:2.87E-5 ID:SGTC_1938|Compound:st074717|FD-Score:-4.01|P-value:4.53E-5 ID:SGTC_2025|Compound:5147754|FD-Score:-3.97|P-value:5.20E-5 ID:SGTC_2027|Compound:5150920|FD-Score:-3.45|P-value:3.80E-4 ID:SGTC_2270|Compound:7924575|FD-Score:5.11|P-value:3.57E-7 ID:SGTC_2309|Compound:7664088|FD-Score:-3.78|P-value:1.10E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.24|P-value:8.58E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.96|P-value:6.51E-7 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.27|P-value:6.86E-4 ID:SGTC_2791|Compound:5663188|FD-Score:-3.41|P-value:4.32E-4 ID:SGTC_2794|Compound:7785382|FD-Score:-3.75|P-value:1.25E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.46|P-value:3.66E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.73|P-value:1.37E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.42|P-value:4.71E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-4.99|P-value:5.59E-7 ID:SGTC_2944|Compound:9067346|FD-Score:3.22|P-value:9.04E-4 ID:SGTC_2962|Compound:9082311|FD-Score:6.89|P-value:1.11E-11 ID:SGTC_3052|Compound:9092717|FD-Score:3.55|P-value:2.97E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.25|P-value:8.38E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.87|P-value:8.78E-5 ID:SGTC_3262|Compound:9137218|FD-Score:-3.85|P-value:8.50E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.46|P-value:4.11E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.58|P-value:2.32E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.84|P-value:8.69E-5 ID:SGTC_3354|Compound:9151612|FD-Score:-3.17|P-value:9.68E-4

Top fitness defect scores for YMR031C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2962 9082311 6.89 13.2 µM 1.11E-11 2 2.71E-12
2 SGTC_350 k064-0020 5.13 19.8 µM 3.22E-7 heme requiring 11 1.43E-7
3 SGTC_2270 7924575 5.11 90.9 µM 3.57E-7 RPP1 & pyrimidine depletion 5 1.59E-7
4 SGTC_1539 benzyladenosine 4.96 56.0 µM 7.44E-7 2 3.46E-7
5 SGTC_1728 st035614 4.23 33.8 µM 2.08E-5 37 1.17E-5
6 SGTC_362 0310-0100 4.21 9.0 µM 2.30E-5 RPP1 & pyrimidine depletion 28 1.30E-5
7 SGTC_1550 gossypolone 4.11 36.6 µM 3.42E-5 12 1.98E-5
8 SGTC_1013 4112-3890 3.95 241.0 µM 6.42E-5 TSC3-RPN4 30 3.86E-5
9 SGTC_3245 9134821 3.87 49.5 µM 8.78E-5 19 5.38E-5
10 SGTC_752 1896-0090 3.70 130.0 µM 1.72E-4 TSC3-RPN4 23 1.09E-4
11 SGTC_572 0960-0087 3.69 17.7 µM 1.79E-4 33 1.14E-4
12 SGTC_1163 k060-0048 3.66 49.9 µM 1.93E-4 31 1.24E-4
13 SGTC_1555 citronellol 3.66 128.0 µM 1.95E-4 8 1.25E-4
14 SGTC_1819 st053448 3.66 58.6 µM 1.97E-4 amide catabolism 28 1.27E-4
15 SGTC_3052 9092717 3.55 49.5 µM 2.97E-4 46 1.95E-4
16 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.47 150.0 µM 3.89E-4 Golgi 57 2.60E-4
17 SGTC_1015 4130-4525 3.46 82.0 µM 4.10E-4 60S ribosome export 39 2.75E-4
18 SGTC_3278 9139605 3.46 49.5 µM 4.11E-4 29 2.75E-4
19 SGTC_2894 9048625 3.42 32.5 µM 4.71E-4 27 3.18E-4
20 SGTC_1063 disulfiram 3.27 1.8 µM 7.77E-4 53 5.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 3.70E-61 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.196 2.06E-30 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.159 2.63E-20 YML054C CYB2 hom Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
0.154 2.51E-19 YDR143C SAN1 hom Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition
0.153 5.14E-19 YER004W FMP52 hom Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
0.144 4.51E-17 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.138 8.64E-16 YMR041C ARA2 hom NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.130 3.85E-14 YDL235C YPD1 het Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus
0.126 2.23E-13 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.117 8.95E-12 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.117 8.98E-12 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.111 1.04E-10 YNR032W PPG1 hom Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
0.109 2.74E-10 YIL166C_p YIL166C_p hom Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
0.108 3.50E-10 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.104 1.72E-9 YOR360C PDE2 hom High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon