HIPHOP chemogenomics database

YMR031W-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR031W-A / YMR031W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YMR031W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_377	3970-0964	10.10	33.1 µM	1.19E-24		1	4.21E-24
2	SGTC_1287	0971-0001	9.85	34.6 µM	1.07E-23	sphingolipid biosynthesis & PDR1	10	3.59E-23
3	SGTC_505	gw-5074	9.31	63.9 µM	2.13E-21		14	6.27E-21
4	SGTC_1687	st020778	8.36	55.4 µM	1.34E-17		64	3.20E-17
5	SGTC_528	3492-0019	8.30	172.0 µM	2.30E-17	calcium & mitochondrial duress	65	5.41E-17
6	SGTC_955	1216-0110	7.87	33.0 µM	8.50E-16	sphingolipid biosynthesis & PDR1	21	1.83E-15
7	SGTC_1801	st050089	6.44	28.4 µM	3.55E-11	NEO1-PIK1	44	5.92E-11
8	SGTC_1803	st050068	6.40	52.4 µM	4.82E-11	NEO1-PIK1	68	7.98E-11
9	SGTC_682	0kpi-0099	6.34	17.0 µM	6.78E-11		21	1.11E-10
10	SGTC_1941	st076221	6.22	61.8 µM	1.53E-10	sphingolipid biosynthesis & PDR1	30	2.47E-10
11	SGTC_743	1275-0778	6.04	158.0 µM	4.78E-10	excess fatty acid	12	7.50E-10
12	SGTC_459	nigericin	5.64	15.3 µM	5.69E-9		38	8.42E-9
13	SGTC_3025	9087895	5.54	49.5 µM	1.02E-8	PDR1	17	1.49E-8
14	SGTC_1956	st077085	5.36	54.0 µM	2.87E-8		3	4.09E-8
15	SGTC_893	0958-0369	5.26	48.9 µM	5.21E-8		9	7.32E-8
16	SGTC_1263	0774-1208	5.21	64.8 µM	6.80E-8		18	9.50E-8
17	SGTC_543	3844-1095	5.14	191.0 µM	9.68E-8	ERG2	24	1.34E-7
18	SGTC_951	1171-0579	5.13	82.7 µM	1.02E-7	cell wall	42	1.41E-7
19	SGTC_2482	5981709	5.01	142.7 µM	2.05E-7	PDR1	20	2.79E-7
20	SGTC_829	1635-0120	4.90	117.0 µM	3.48E-7	DNA damage response	23	4.67E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.428	3.68E-149	YLR204W	QRI5	hom	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.403	9.04E-131	YGR164W_d	YGR164W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.342	2.67E-92	YDR120C	TRM1	hom	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.331	1.41E-86	YBL079W	NUP170	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.326	9.40E-84	YOL050C_d	YOL050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.324	7.45E-83	YLR087C	CSF1	hom	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.307	3.25E-74	YNL237W	YTP1	hom	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.295	4.49E-68	YJR074W	MOG1	hom	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.294	8.18E-68	YDR392W	SPT3	hom	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.291	2.03E-66	YIL170W	HXT12	hom	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.271	2.45E-57	YLR055C	SPT8	hom	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.257	1.24E-51	YKR093W	PTR2	hom	Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.248	2.76E-48	YGL013C	PDR1	hom	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.243	2.61E-46	YMR015C	ERG5	hom	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
0.236	1.66E-43	YDR093W	DNF2	hom	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase