YMR035W / IMP2

Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR035W / IMP2

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.19|P-value:1.76E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.38|P-value:7.82E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.19|P-value:1.81E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.61|P-value:1.35E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:4.79|P-value:4.56E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:9.76|P-value:8.97E-28 ID:SGTC_141|Compound:0443-0274|FD-Score:3.26|P-value:1.30E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.00|P-value:4.93E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.20|P-value:1.73E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.26|P-value:3.10E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:4.03|P-value:3.34E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:3.49|P-value:4.71E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.19|P-value:2.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:28.90|P-value:4.79E-226 ID:SGTC_310|Compound:1273-0058|FD-Score:3.43|P-value:6.34E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:2.80|P-value:8.64E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.02|P-value:3.63E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:10.30|P-value:1.83E-30 ID:SGTC_795|Compound:0685-0265|FD-Score:2.76|P-value:9.79E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.24|P-value:1.42E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.14|P-value:1.85E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.27|P-value:1.24E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.42|P-value:8.43E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.86|P-value:6.88E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.83|P-value:7.59E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.70|P-value:1.81E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.30|P-value:1.10E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.05|P-value:3.14E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:2.76|P-value:9.77E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.08|P-value:3.53E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.91|P-value:5.66E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.11|P-value:3.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.24|P-value:1.47E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.23|P-value:1.50E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.81|P-value:8.30E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.10|P-value:7.10E-42 ID:SGTC_1757|Compound:st041620|FD-Score:-2.94|P-value:6.12E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.48|P-value:5.00E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.93|P-value:5.51E-6 ID:SGTC_2073|Compound:5212005|FD-Score:3.39|P-value:7.34E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.05|P-value:3.25E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.94|P-value:6.18E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:2.86|P-value:6.90E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.82|P-value:1.26E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.96|P-value:1.56E-8 ID:SGTC_2264|Compound:7948757|FD-Score:6.09|P-value:5.67E-12 ID:SGTC_2265|Compound:7929201|FD-Score:5.02|P-value:1.07E-8 ID:SGTC_2273|Compound:7815444|FD-Score:-3.22|P-value:1.94E-4 ID:SGTC_2279|Compound:7948423|FD-Score:2.85|P-value:6.97E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.66|P-value:2.72E-5 ID:SGTC_2347|Compound:9049783|FD-Score:2.76|P-value:9.89E-4 ID:SGTC_2413|Compound:inermin|FD-Score:6.01|P-value:1.03E-11 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:5.40E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-2.96|P-value:5.64E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:2.99|P-value:4.15E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.71|P-value:2.14E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.56|P-value:4.48E-5 ID:SGTC_2951|Compound:9072950|FD-Score:4.55|P-value:1.85E-7 ID:SGTC_3195|Compound:9113082|FD-Score:3.95|P-value:5.07E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-3.92|P-value:7.80E-6 ID:SGTC_3334|Compound:9142812|FD-Score:3.65|P-value:2.20E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.19|P-value:1.76E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:3.38|P-value:7.82E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:3.19|P-value:1.81E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.61|P-value:1.35E-7 ID:SGTC_116|Compound:0155-0182|FD-Score:4.79|P-value:4.56E-8 ID:SGTC_134|Compound:0269-0018|FD-Score:9.76|P-value:8.97E-28 ID:SGTC_141|Compound:0443-0274|FD-Score:3.26|P-value:1.30E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.00|P-value:4.93E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.20|P-value:1.73E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.26|P-value:3.10E-9 ID:SGTC_156|Compound:3474-0145|FD-Score:4.03|P-value:3.34E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:3.49|P-value:4.71E-5 ID:SGTC_231|Compound:b-estradiol|FD-Score:-3.19|P-value:2.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:28.90|P-value:4.79E-226 ID:SGTC_310|Compound:1273-0058|FD-Score:3.43|P-value:6.34E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:2.80|P-value:8.64E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.02|P-value:3.63E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:10.30|P-value:1.83E-30 ID:SGTC_795|Compound:0685-0265|FD-Score:2.76|P-value:9.79E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.24|P-value:1.42E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:2.78|P-value:9.14E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:4.14|P-value:1.85E-6 ID:SGTC_1015|Compound:4130-4525|FD-Score:-4.27|P-value:1.24E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.42|P-value:8.43E-5 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.86|P-value:6.88E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.83|P-value:7.59E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.70|P-value:1.81E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.30|P-value:1.10E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.05|P-value:3.14E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:2.76|P-value:9.77E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.08|P-value:3.53E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:2.91|P-value:5.66E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:-3.11|P-value:3.05E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.09|P-value:2.68E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.24|P-value:1.47E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.23|P-value:1.50E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:2.81|P-value:8.30E-4 ID:SGTC_1635|Compound:st007035|FD-Score:12.10|P-value:7.10E-42 ID:SGTC_1757|Compound:st041620|FD-Score:-2.94|P-value:6.12E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.48|P-value:5.00E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.93|P-value:5.51E-6 ID:SGTC_2073|Compound:5212005|FD-Score:3.39|P-value:7.34E-5 ID:SGTC_2075|Compound:5212009|FD-Score:3.05|P-value:3.25E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.94|P-value:6.18E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:2.86|P-value:6.90E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.82|P-value:1.26E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.96|P-value:1.56E-8 ID:SGTC_2264|Compound:7948757|FD-Score:6.09|P-value:5.67E-12 ID:SGTC_2265|Compound:7929201|FD-Score:5.02|P-value:1.07E-8 ID:SGTC_2273|Compound:7815444|FD-Score:-3.22|P-value:1.94E-4 ID:SGTC_2279|Compound:7948423|FD-Score:2.85|P-value:6.97E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.66|P-value:2.72E-5 ID:SGTC_2347|Compound:9049783|FD-Score:2.76|P-value:9.89E-4 ID:SGTC_2413|Compound:inermin|FD-Score:6.01|P-value:1.03E-11 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.92|P-value:5.40E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-2.96|P-value:5.64E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:2.99|P-value:4.15E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.71|P-value:2.14E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-3.56|P-value:4.48E-5 ID:SGTC_2951|Compound:9072950|FD-Score:4.55|P-value:1.85E-7 ID:SGTC_3195|Compound:9113082|FD-Score:3.95|P-value:5.07E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-3.92|P-value:7.80E-6 ID:SGTC_3334|Compound:9142812|FD-Score:3.65|P-value:2.20E-5

Top fitness defect scores for YMR035W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 28.90 5.3 µM 4.79E-226 19 1.23E-183
2 SGTC_1635 st007035 12.10 42.4 µM 7.10E-42 60 3.09E-34
3 SGTC_386 1509-0011 10.30 3.1 µM 1.83E-30 43 5.58E-25
4 SGTC_134 0269-0018 9.76 6.9 µM 8.97E-28 41 8.50E-23
5 SGTC_2264 7948757 6.09 110.8 µM 5.67E-12 1 5.65E-10
6 SGTC_2413 inermin 6.01 26.1 µM 1.03E-11 18 9.20E-10
7 SGTC_2265 7929201 5.02 200.0 µM 1.07E-8 8 2.60E-7
8 SGTC_2250 alverine citrate 4.96 130.0 µM 1.56E-8 95 3.51E-7
9 SGTC_116 0155-0182 4.79 31.8 µM 4.56E-8 mitochondrial response to ROS 45 8.43E-7
10 SGTC_87 0100-0052 4.61 35.5 µM 1.35E-7 67 2.04E-6
11 SGTC_2951 9072950 4.55 58.1 µM 1.85E-7 ERG2 13 2.63E-6
12 SGTC_1011 4112-3381 4.14 17.4 µM 1.85E-6 35 1.72E-5
13 SGTC_156 3474-0145 4.03 5.6 µM 3.34E-6 endomembrane recycling 49 2.77E-5
14 SGTC_3195 9113082 3.95 49.5 µM 5.07E-6 19 3.90E-5
15 SGTC_2019 4016004 3.93 108.0 µM 5.51E-6 33 4.17E-5
16 SGTC_1119 parthenolide 3.70 318.5 nM 1.81E-5 TSC3-RPN4 45 1.10E-4
17 SGTC_3334 9142812 3.65 21.9 µM 2.20E-5 35 1.29E-4
18 SGTC_196 k015-0023 3.49 18.1 µM 4.71E-5 PDR1 37 2.40E-4
19 SGTC_1847 st056231 3.48 15.0 µM 5.00E-5 47 2.52E-4
20 SGTC_310 1273-0058 3.43 1.1 µM 6.34E-5 mitochondrial stress 298 3.06E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.732 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.721 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.709 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.695 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.674 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.672 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.671 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.665 0 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.663 0 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.662 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.655 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.653 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.653 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.653 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.649 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase