YMR040W / YET2

Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR040W / YET2

Click on Significant Values for Screen Details ID:SGTC_822|Compound:1487-0950|FD-Score:-4.11|P-value:2.58E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.69|P-value:1.38E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.95|P-value:5.84E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.68|P-value:2.44E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.41|P-value:3.76E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.77|P-value:1.01E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.40|P-value:4.64E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.46|P-value:3.70E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.26|P-value:6.42E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.44|P-value:3.45E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.14|P-value:9.61E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.31|P-value:5.48E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.47|P-value:3.10E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.50|P-value:2.77E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.47|P-value:3.10E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.31|P-value:5.46E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.31|P-value:5.35E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-4.11|P-value:2.58E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:-3.69|P-value:1.38E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.95|P-value:5.84E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.68|P-value:2.44E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.41|P-value:3.76E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.77|P-value:1.01E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.40|P-value:4.64E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.46|P-value:3.70E-4 ID:SGTC_1935|Compound:st074532|FD-Score:-3.26|P-value:6.42E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.44|P-value:3.45E-4 ID:SGTC_2052|Compound:5265182|FD-Score:-3.14|P-value:9.61E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.31|P-value:5.48E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.47|P-value:3.10E-4 ID:SGTC_2935|Compound:9038016|FD-Score:-3.50|P-value:2.77E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.47|P-value:3.10E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.31|P-value:5.46E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.31|P-value:5.35E-4

Top fitness defect scores for YMR040W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1204 4049-0315 4.68 18.3 µM 2.44E-6 9 1.41E-6
2 SGTC_962 1254-0300 3.95 21.5 µM 5.84E-5 22 3.88E-5
3 SGTC_1782 st039423 3.46 80.6 µM 3.70E-4 33 2.66E-4
4 SGTC_1594 piperine 3.40 70.1 µM 4.64E-4 28 3.37E-4
5 SGTC_375 3970-0961 3.11 9.3 µM 0.00122 tubulin folding & SWR complex 55 9.23E-4
6 SGTC_94 0334-0113 2.99 514.8 µM 0.00181 64 0.00140
7 SGTC_823 0417-1665 2.98 178.0 µM 0.00186 78 0.00144
8 SGTC_880 0833-0487 2.78 87.2 µM 0.00348 mitochondrial processes 66 0.00276
9 SGTC_850 0388-0143 2.73 75.9 µM 0.00394 77 0.00314
10 SGTC_818 4072-2707 2.65 53.5 µM 0.00493 74 0.00397
11 SGTC_2580 diallyl disulphide 2.57 81.4 µM 0.00620 104 0.00504
12 SGTC_76 0433-0009 2.56 400.3 µM 0.00636 61 0.00518
13 SGTC_966 1300-0360 2.55 30.2 µM 0.00663 heme requiring 115 0.00541
14 SGTC_1160 4092-0570 2.52 10.5 µM 0.00711 plasma membrane duress 140 0.00581
15 SGTC_2095 5432005 2.51 200.0 µM 0.00730 87 0.00598
16 SGTC_1723 st034307 2.49 2.5 µM 0.00778 mitochondrial processes 126 0.00640
17 SGTC_2484 5809818 2.46 12.0 µM 0.00854 106 0.00704
18 SGTC_2690 usnic acid 2.45 100.0 µM 0.00873 151 0.00721
19 SGTC_954 1189-0853 2.42 2.9 µM 0.00927 endomembrane recycling 151 0.00767
20 SGTC_2962 9082311 2.42 13.2 µM 0.00936 131 0.00776

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 2.75E-57 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.197 9.28E-31 YLR084C RAX2 hom N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p
0.178 3.51E-25 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.176 1.16E-24 YLR186W EMG1 het Methyltransferase for rRNA; catalyzes methylation of the pseudouridine residue 1191 of 18S rRNA; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independently of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and the equivalent mutation in yeast affects Emg1p dimerization and localization but not its methyltransferase activity
0.130 4.12E-14 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.121 2.41E-12 YJL077W-B_p YJL077W-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.107 4.87E-10 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.107 5.40E-10 YMR026C PEX12 hom C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder
0.106 8.32E-10 YPL041C_p YPL041C_p hom Protein of unknown function involved in maintenance of proper telomere length
0.103 2.32E-9 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.102 3.37E-9 YJL007C_d YJL007C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 6.17E-9 YML005W TRM12 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
0.100 6.28E-9 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.097 1.76E-8 YLR387C REH1 hom Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
0.094 4.93E-8 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway