YMR041C / ARA2

NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR041C / ARA2

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.84|P-value:5.66E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.36|P-value:5.64E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.50|P-value:2.92E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.12|P-value:8.56E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.40|P-value:3.15E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.18|P-value:7.09E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.10|P-value:9.36E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.31|P-value:4.45E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.12|P-value:8.68E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.02|P-value:2.60E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.88|P-value:4.87E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.09|P-value:9.44E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.49|P-value:1.95E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.54|P-value:1.86E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.43|P-value:2.79E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.36|P-value:3.63E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.21|P-value:6.41E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.70|P-value:9.93E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-4.92|P-value:3.61E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.11|P-value:3.74E-10 ID:SGTC_2591|Compound:skatole|FD-Score:3.63|P-value:1.12E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.50|P-value:2.14E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.38|P-value:4.34E-6 ID:SGTC_2935|Compound:9038016|FD-Score:-4.69|P-value:1.17E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.82|P-value:5.11E-5 ID:SGTC_3151|Compound:9099821|FD-Score:5.09|P-value:1.14E-7 ID:SGTC_3156|Compound:9099931|FD-Score:3.32|P-value:3.65E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.76|P-value:7.97E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.05|P-value:9.46E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.23|P-value:5.07E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.23|P-value:5.07E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.16|P-value:7.50E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.38|P-value:3.44E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.94|P-value:3.04E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-3.11|P-value:8.92E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.43|P-value:2.39E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.84|P-value:5.66E-5 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.36|P-value:5.64E-6 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.50|P-value:2.92E-6 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.12|P-value:8.56E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.40|P-value:3.15E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.18|P-value:7.09E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.10|P-value:9.36E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.31|P-value:4.45E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:-3.12|P-value:8.68E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.02|P-value:2.60E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.88|P-value:4.87E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.09|P-value:9.44E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.49|P-value:1.95E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:-3.54|P-value:1.86E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:-3.43|P-value:2.79E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.36|P-value:3.63E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.21|P-value:6.41E-4 ID:SGTC_1805|Compound:st050013|FD-Score:-3.70|P-value:9.93E-5 ID:SGTC_1916|Compound:st067606|FD-Score:-4.92|P-value:3.61E-7 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-6.11|P-value:3.74E-10 ID:SGTC_2591|Compound:skatole|FD-Score:3.63|P-value:1.12E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.50|P-value:2.14E-4 ID:SGTC_2786|Compound:7743617|FD-Score:4.38|P-value:4.34E-6 ID:SGTC_2935|Compound:9038016|FD-Score:-4.69|P-value:1.17E-6 ID:SGTC_2962|Compound:9082311|FD-Score:3.82|P-value:5.11E-5 ID:SGTC_3151|Compound:9099821|FD-Score:5.09|P-value:1.14E-7 ID:SGTC_3156|Compound:9099931|FD-Score:3.32|P-value:3.65E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.76|P-value:7.97E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.05|P-value:9.46E-4 ID:SGTC_3175|Compound:9106517|FD-Score:3.03|P-value:9.98E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.23|P-value:5.07E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.23|P-value:5.07E-4 ID:SGTC_3231|Compound:9132313|FD-Score:-3.16|P-value:7.50E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.38|P-value:3.44E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.94|P-value:3.04E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-3.11|P-value:8.92E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.43|P-value:2.39E-4

Top fitness defect scores for YMR041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3151 9099821 5.09 49.5 µM 1.14E-7 6 1.75E-7
2 SGTC_2786 7743617 4.38 45.5 µM 4.34E-6 17 6.05E-6
3 SGTC_3302 9125395 3.94 16.4 µM 3.04E-5 9 4.02E-5
4 SGTC_2962 9082311 3.82 13.2 µM 5.11E-5 26 6.67E-5
5 SGTC_2591 skatole 3.63 100.0 µM 1.12E-4 32 1.44E-4
6 SGTC_1301 naphtanilide LB 3.49 4.8 µM 1.95E-4 heme requiring 18 2.46E-4
7 SGTC_3316 9136639 3.43 10.6 µM 2.39E-4 27 2.99E-4
8 SGTC_3156 9099931 3.32 49.5 µM 3.65E-4 23 4.53E-4
9 SGTC_3218 9131285 3.23 49.5 µM 5.07E-4 endomembrane recycling 86 6.23E-4
10 SGTC_3203 9113543 3.23 49.5 µM 5.07E-4 61 6.23E-4
11 SGTC_3174 9107204 3.05 49.5 µM 9.46E-4 ERG2 75 0.00114
12 SGTC_3175 9106517 3.03 49.5 µM 9.98E-4 iron homeostasis 46 0.00121
13 SGTC_2404 5161160 3.01 200.0 µM 0.00109 66 0.00132
14 SGTC_1594 piperine 2.98 70.1 µM 0.00119 61 0.00143
15 SGTC_1777 st045864 2.85 34.8 µM 0.00184 45 0.00219
16 SGTC_1342 1486-1464 2.81 234.0 µM 0.00208 68 0.00246
17 SGTC_448 monastrol 2.79 171.0 µM 0.00224 49 0.00265
18 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 2.75 100.0 µM 0.00256 60S ribosome export 85 0.00302
19 SGTC_1452 4194-0072 2.73 190.0 µM 0.00268 79 0.00315
20 SGTC_123 0083-0120 2.72 66.7 µM 0.00278 122 0.00327

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.300 6.44E-71 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.218 2.77E-37 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.212 1.64E-35 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.209 1.46E-34 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.194 7.47E-30 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.188 3.48E-28 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.188 3.65E-28 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.187 7.27E-28 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.175 1.33E-24 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.171 2.26E-23 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.168 1.30E-22 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.167 1.80E-22 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.162 3.69E-21 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.162 4.03E-21 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.154 3.31E-19 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport