YMR052W / FAR3

Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR052W / FAR3

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:6.31|P-value:1.60E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:3.38|P-value:7.81E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:15.20|P-value:1.95E-46 ID:SGTC_141|Compound:0443-0274|FD-Score:3.53|P-value:4.76E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.42|P-value:6.79E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.17|P-value:4.66E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:7.53|P-value:7.91E-13 ID:SGTC_384|Compound:k007-0144|FD-Score:8.31|P-value:3.10E-15 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.30|P-value:9.94E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.97|P-value:8.97E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.42|P-value:6.30E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.76|P-value:2.11E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.07|P-value:6.75E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.89|P-value:1.36E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.92|P-value:1.20E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.50|P-value:5.18E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.31|P-value:9.62E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:5.94|P-value:1.25E-8 ID:SGTC_635|Compound:k038-0028|FD-Score:3.42|P-value:6.84E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.12|P-value:5.75E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.85|P-value:2.67E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:7.59|P-value:5.27E-13 ID:SGTC_805|Compound:3852-0218|FD-Score:6.00|P-value:9.28E-9 ID:SGTC_975|Compound:1335-0046|FD-Score:3.30|P-value:9.93E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.66|P-value:6.37E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.35|P-value:2.70E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.90|P-value:1.27E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.61|P-value:7.07E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.47|P-value:1.39E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.36|P-value:8.39E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.55|P-value:4.36E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.33|P-value:9.03E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.81|P-value:1.81E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.20|P-value:4.15E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.62|P-value:3.49E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.37|P-value:8.08E-4 ID:SGTC_2083|Compound:5306046|FD-Score:5.43|P-value:1.75E-7 ID:SGTC_2090|Compound:5301565|FD-Score:-3.87|P-value:1.32E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.46|P-value:1.46E-5 ID:SGTC_2099|Compound:5377090|FD-Score:4.92|P-value:1.95E-6 ID:SGTC_2160|Compound:5660466|FD-Score:3.95|P-value:1.07E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.56|P-value:4.26E-4 ID:SGTC_2346|Compound:9031566|FD-Score:5.23|P-value:4.72E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.67|P-value:2.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.50|P-value:2.84E-23 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.09|P-value:6.32E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:7.01|P-value:2.36E-11 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.95|P-value:1.08E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.65|P-value:6.57E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.67|P-value:2.93E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.50|P-value:1.27E-7 ID:SGTC_2824|Compound:7998404|FD-Score:6.14|P-value:4.18E-9 ID:SGTC_2825|Compound:7998094|FD-Score:3.90|P-value:1.28E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.34|P-value:8.88E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.38|P-value:7.68E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.97|P-value:1.39E-6 ID:SGTC_2986|Compound:9022445|FD-Score:4.14|P-value:5.29E-5 ID:SGTC_3004|Compound:9076122|FD-Score:4.11|P-value:5.81E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.92|P-value:2.02E-6 ID:SGTC_3086|Compound:9117350|FD-Score:5.10|P-value:8.53E-7 ID:SGTC_3093|Compound:9117344|FD-Score:4.15|P-value:5.03E-5 ID:SGTC_3095|Compound:9117207|FD-Score:6.33|P-value:1.42E-9 ID:SGTC_3142|Compound:9086498|FD-Score:3.34|P-value:8.72E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-6.70|P-value:1.39E-10 ID:SGTC_3145|Compound:9085516|FD-Score:-3.66|P-value:2.74E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-4.20|P-value:3.76E-5 ID:SGTC_3158|Compound:9100007|FD-Score:11.30|P-value:1.68E-26 ID:SGTC_3245|Compound:9134821|FD-Score:4.00|P-value:9.06E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:6.31|P-value:1.60E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:3.38|P-value:7.81E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:15.20|P-value:1.95E-46 ID:SGTC_141|Compound:0443-0274|FD-Score:3.53|P-value:4.76E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.42|P-value:6.79E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.17|P-value:4.66E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:7.53|P-value:7.91E-13 ID:SGTC_384|Compound:k007-0144|FD-Score:8.31|P-value:3.10E-15 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.30|P-value:9.94E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.97|P-value:8.97E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.42|P-value:6.30E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.76|P-value:2.11E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:4.07|P-value:6.75E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.89|P-value:1.36E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.92|P-value:1.20E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.76|P-value:2.14E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:3.50|P-value:5.18E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:3.31|P-value:9.62E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:5.94|P-value:1.25E-8 ID:SGTC_635|Compound:k038-0028|FD-Score:3.42|P-value:6.84E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.12|P-value:5.75E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:3.75|P-value:2.22E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:4.85|P-value:2.67E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:7.59|P-value:5.27E-13 ID:SGTC_805|Compound:3852-0218|FD-Score:6.00|P-value:9.28E-9 ID:SGTC_975|Compound:1335-0046|FD-Score:3.30|P-value:9.93E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.66|P-value:6.37E-6 ID:SGTC_1161|Compound:k007-0610|FD-Score:7.35|P-value:2.70E-12 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.90|P-value:1.27E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.61|P-value:7.07E-6 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.47|P-value:1.39E-5 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.36|P-value:8.39E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:3.55|P-value:4.36E-4 ID:SGTC_1675|Compound:st018485|FD-Score:3.33|P-value:9.03E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.81|P-value:1.81E-4 ID:SGTC_1860|Compound:st056228|FD-Score:4.20|P-value:4.15E-5 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.62|P-value:3.49E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.37|P-value:8.08E-4 ID:SGTC_2083|Compound:5306046|FD-Score:5.43|P-value:1.75E-7 ID:SGTC_2090|Compound:5301565|FD-Score:-3.87|P-value:1.32E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.46|P-value:1.46E-5 ID:SGTC_2099|Compound:5377090|FD-Score:4.92|P-value:1.95E-6 ID:SGTC_2160|Compound:5660466|FD-Score:3.95|P-value:1.07E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.56|P-value:4.26E-4 ID:SGTC_2346|Compound:9031566|FD-Score:5.23|P-value:4.72E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:3.67|P-value:2.96E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:10.50|P-value:2.84E-23 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.09|P-value:6.32E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:7.01|P-value:2.36E-11 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.95|P-value:1.08E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:4.65|P-value:6.57E-6 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.67|P-value:2.93E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.50|P-value:1.27E-7 ID:SGTC_2824|Compound:7998404|FD-Score:6.14|P-value:4.18E-9 ID:SGTC_2825|Compound:7998094|FD-Score:3.90|P-value:1.28E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.34|P-value:8.88E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.38|P-value:7.68E-4 ID:SGTC_2978|Compound:9011784|FD-Score:-4.97|P-value:1.39E-6 ID:SGTC_2986|Compound:9022445|FD-Score:4.14|P-value:5.29E-5 ID:SGTC_3004|Compound:9076122|FD-Score:4.11|P-value:5.81E-5 ID:SGTC_3081|Compound:9117243|FD-Score:4.92|P-value:2.02E-6 ID:SGTC_3086|Compound:9117350|FD-Score:5.10|P-value:8.53E-7 ID:SGTC_3093|Compound:9117344|FD-Score:4.15|P-value:5.03E-5 ID:SGTC_3095|Compound:9117207|FD-Score:6.33|P-value:1.42E-9 ID:SGTC_3142|Compound:9086498|FD-Score:3.34|P-value:8.72E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-6.70|P-value:1.39E-10 ID:SGTC_3145|Compound:9085516|FD-Score:-3.66|P-value:2.74E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-4.20|P-value:3.76E-5 ID:SGTC_3158|Compound:9100007|FD-Score:11.30|P-value:1.68E-26 ID:SGTC_3245|Compound:9134821|FD-Score:4.00|P-value:9.06E-5

Top fitness defect scores for YMR052W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 15.20 51.8 µM 1.95E-46 ERAD & cell cycle 9 2.34E-52
2 SGTC_3158 9100007 11.30 49.5 µM 1.68E-26 1 8.53E-30
3 SGTC_2582 agaric acid 10.50 100.0 µM 2.84E-23 redox potentiating 57 3.84E-26
4 SGTC_384 k007-0144 8.31 5.2 µM 3.10E-15 ERAD & cell cycle 14 4.78E-17
5 SGTC_733 4069-0007 7.59 56.1 µM 5.27E-13 ERAD & cell cycle 23 1.60E-14
6 SGTC_373 0844-0104 7.53 25.9 µM 7.91E-13 ERAD & cell cycle 14 2.52E-14
7 SGTC_1161 k007-0610 7.35 110.0 µM 2.70E-12 ERAD & cell cycle 34 1.01E-13
8 SGTC_2730 imipramine 7.01 71.3 µM 2.36E-11 2 1.17E-12
9 SGTC_3095 9117207 6.33 49.5 µM 1.42E-9 1 1.21E-10
10 SGTC_64 000l-0018 6.31 272.1 µM 1.60E-9 ubiquinone biosynthesis & proteasome 71 1.38E-10
11 SGTC_2824 7998404 6.14 52.0 µM 4.18E-9 6 4.09E-10
12 SGTC_805 3852-0218 6.00 479.0 µM 9.28E-9 ERAD & cell cycle 23 1.01E-9
13 SGTC_624 k048-0052 5.94 28.0 µM 1.25E-8 Golgi 5 1.41E-9
14 SGTC_2821 7996764 5.50 71.4 µM 1.27E-7 13 1.93E-8
15 SGTC_2083 5306046 5.43 65.9 µM 1.75E-7 2 2.79E-8
16 SGTC_2346 9031566 5.23 143.8 µM 4.72E-7 Golgi 6 8.54E-8
17 SGTC_3086 9117350 5.10 49.5 µM 8.53E-7 1 1.67E-7
18 SGTC_2099 5377090 4.92 177.4 µM 1.95E-6 8 4.25E-7
19 SGTC_3081 9117243 4.92 49.5 µM 2.02E-6 fatty acid desaturase (OLE1) 10 4.41E-7
20 SGTC_669 0108-0021 4.85 26.2 µM 2.67E-6 fatty acid desaturase (OLE1) 40 6.04E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.423 6.48E-146 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.419 9.50E-143 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.403 6.07E-131 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.387 1.62E-120 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.374 5.35E-112 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.372 1.29E-110 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.366 4.73E-107 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.350 3.79E-97 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.320 1.84E-80 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.294 1.10E-67 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.291 1.36E-66 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.287 1.46E-64 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.275 1.87E-59 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.271 1.71E-57 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.259 2.37E-52 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene