YMR058W / FET3

Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR058W / FET3

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-3.41|P-value:4.22E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.49|P-value:5.51E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.38|P-value:9.68E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:6.52|P-value:1.43E-10 ID:SGTC_117|Compound:lucigenin|FD-Score:7.34|P-value:5.86E-13 ID:SGTC_139|Compound:0099-0334|FD-Score:4.09|P-value:3.98E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:10.50|P-value:2.04E-24 ID:SGTC_173|Compound:1273-0061|FD-Score:3.82|P-value:1.15E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.05|P-value:4.59E-5 ID:SGTC_263|Compound:alizarin|FD-Score:6.56|P-value:1.08E-10 ID:SGTC_298|Compound:1391-0729|FD-Score:3.70|P-value:1.77E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.40|P-value:1.05E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.28|P-value:1.83E-5 ID:SGTC_444|Compound:curcumin|FD-Score:4.75|P-value:2.19E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.29|P-value:7.59E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.70|P-value:1.79E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.25|P-value:2.08E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:10.90|P-value:1.34E-26 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.72|P-value:1.37E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.01|P-value:5.53E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.11|P-value:3.94E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.58|P-value:3.40E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.61|P-value:2.94E-8 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.80|P-value:1.00E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.58|P-value:2.80E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:5.05|P-value:5.17E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.78|P-value:1.90E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.21|P-value:9.94E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.15|P-value:3.14E-5 ID:SGTC_1658|Compound:st012944|FD-Score:9.21|P-value:2.15E-19 ID:SGTC_1660|Compound:st012960|FD-Score:3.29|P-value:7.62E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.55|P-value:2.52E-4 ID:SGTC_1830|Compound:st055982|FD-Score:4.26|P-value:1.93E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.97|P-value:6.41E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.57|P-value:2.86E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.21|P-value:9.85E-4 ID:SGTC_2046|Compound:4110841|FD-Score:11.60|P-value:1.14E-29 ID:SGTC_2068|Compound:5226020|FD-Score:3.58|P-value:2.79E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.02|P-value:5.24E-5 ID:SGTC_2144|Compound:5628481|FD-Score:3.91|P-value:8.11E-5 ID:SGTC_2153|Compound:5569715|FD-Score:8.93|P-value:2.43E-18 ID:SGTC_2275|Compound:7947463|FD-Score:19.70|P-value:4.89E-82 ID:SGTC_2284|Compound:7945075|FD-Score:-3.76|P-value:1.18E-4 ID:SGTC_2286|Compound:7945697|FD-Score:8.13|P-value:1.74E-15 ID:SGTC_2291|Compound:7917025|FD-Score:55.00|P-value:0 ID:SGTC_2330|Compound:7979373|FD-Score:4.63|P-value:3.80E-6 ID:SGTC_2389|Compound:9091542|FD-Score:7.19|P-value:1.75E-12 ID:SGTC_2398|Compound:5228213|FD-Score:3.41|P-value:5.01E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:8.23|P-value:8.02E-16 ID:SGTC_2551|Compound:apiole|FD-Score:3.37|P-value:5.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.01|P-value:3.09E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:5.77|P-value:1.22E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:8.46|P-value:1.23E-16 ID:SGTC_2847|Compound:9005661|FD-Score:3.23|P-value:9.26E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_3142|Compound:9086498|FD-Score:7.10|P-value:3.18E-12 ID:SGTC_3205|Compound:9113483|FD-Score:4.10|P-value:3.81E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.41|P-value:4.22E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.49|P-value:5.51E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.38|P-value:9.68E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:6.52|P-value:1.43E-10 ID:SGTC_117|Compound:lucigenin|FD-Score:7.34|P-value:5.86E-13 ID:SGTC_139|Compound:0099-0334|FD-Score:4.09|P-value:3.98E-5 ID:SGTC_157|Compound:1348-1695|FD-Score:10.50|P-value:2.04E-24 ID:SGTC_173|Compound:1273-0061|FD-Score:3.82|P-value:1.15E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:3.72|P-value:1.66E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:4.05|P-value:4.59E-5 ID:SGTC_263|Compound:alizarin|FD-Score:6.56|P-value:1.08E-10 ID:SGTC_298|Compound:1391-0729|FD-Score:3.70|P-value:1.77E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:4.40|P-value:1.05E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:4.28|P-value:1.83E-5 ID:SGTC_444|Compound:curcumin|FD-Score:4.75|P-value:2.19E-6 ID:SGTC_663|Compound:1486-0733|FD-Score:3.68|P-value:1.91E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.29|P-value:7.59E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.70|P-value:1.79E-4 ID:SGTC_716|Compound:1683-5115|FD-Score:4.25|P-value:2.08E-5 ID:SGTC_848|Compound:0368-0089|FD-Score:10.90|P-value:1.34E-26 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.72|P-value:1.37E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.01|P-value:5.53E-5 ID:SGTC_1029|Compound:k015-0030|FD-Score:5.11|P-value:3.94E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:5.58|P-value:3.40E-8 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.61|P-value:2.94E-8 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.80|P-value:1.00E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.58|P-value:2.80E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.53|P-value:3.31E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:5.05|P-value:5.17E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:4.78|P-value:1.90E-6 ID:SGTC_1521|Compound:st012942|FD-Score:3.21|P-value:9.94E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:4.15|P-value:3.14E-5 ID:SGTC_1658|Compound:st012944|FD-Score:9.21|P-value:2.15E-19 ID:SGTC_1660|Compound:st012960|FD-Score:3.29|P-value:7.62E-4 ID:SGTC_1752|Compound:st044819|FD-Score:-3.55|P-value:2.52E-4 ID:SGTC_1830|Compound:st055982|FD-Score:4.26|P-value:1.93E-5 ID:SGTC_1834|Compound:st055981|FD-Score:3.97|P-value:6.41E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.57|P-value:2.86E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.21|P-value:9.85E-4 ID:SGTC_2046|Compound:4110841|FD-Score:11.60|P-value:1.14E-29 ID:SGTC_2068|Compound:5226020|FD-Score:3.58|P-value:2.79E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.02|P-value:5.24E-5 ID:SGTC_2144|Compound:5628481|FD-Score:3.91|P-value:8.11E-5 ID:SGTC_2153|Compound:5569715|FD-Score:8.93|P-value:2.43E-18 ID:SGTC_2275|Compound:7947463|FD-Score:19.70|P-value:4.89E-82 ID:SGTC_2284|Compound:7945075|FD-Score:-3.76|P-value:1.18E-4 ID:SGTC_2286|Compound:7945697|FD-Score:8.13|P-value:1.74E-15 ID:SGTC_2291|Compound:7917025|FD-Score:55.00|P-value:0 ID:SGTC_2330|Compound:7979373|FD-Score:4.63|P-value:3.80E-6 ID:SGTC_2389|Compound:9091542|FD-Score:7.19|P-value:1.75E-12 ID:SGTC_2398|Compound:5228213|FD-Score:3.41|P-value:5.01E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:8.23|P-value:8.02E-16 ID:SGTC_2551|Compound:apiole|FD-Score:3.37|P-value:5.81E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.01|P-value:3.09E-9 ID:SGTC_2586|Compound:curcumin|FD-Score:5.77|P-value:1.22E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:8.46|P-value:1.23E-16 ID:SGTC_2847|Compound:9005661|FD-Score:3.23|P-value:9.26E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_3142|Compound:9086498|FD-Score:7.10|P-value:3.18E-12 ID:SGTC_3205|Compound:9113483|FD-Score:4.10|P-value:3.81E-5

Top fitness defect scores for YMR058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2291 7917025 55.00 104.3 µM 0 iron homeostasis 1 0
2 SGTC_2275 7947463 19.70 200.0 µM 4.89E-82 iron homeostasis 1 5.90E-87
3 SGTC_2046 4110841 11.60 106.0 µM 1.14E-29 iron homeostasis 2 1.96E-31
4 SGTC_848 0368-0089 10.90 85.6 µM 1.34E-26 iron homeostasis 1 3.54E-28
5 SGTC_157 1348-1695 10.50 65.8 µM 2.04E-24 iron homeostasis 11 7.31E-26
6 SGTC_1658 st012944 9.21 20.0 µM 2.15E-19 iron homeostasis 4 1.56E-20
7 SGTC_2153 5569715 8.93 200.0 µM 2.43E-18 iron homeostasis 2 2.04E-19
8 SGTC_2675 theaflavin digallate 8.46 100.0 µM 1.23E-16 iron homeostasis 4 1.31E-17
9 SGTC_2418 pentamidine 8.23 31.7 µM 8.02E-16 mitochondrial processes 6 9.61E-17
10 SGTC_2286 7945697 8.13 125.0 µM 1.74E-15 7 2.18E-16
11 SGTC_117 lucigenin 7.34 22.1 µM 5.86E-13 redox potentiating 27 1.05E-13
12 SGTC_2389 9091542 7.19 195.5 µM 1.75E-12 iron homeostasis 10 3.36E-13
13 SGTC_3142 9086498 7.10 49.5 µM 3.18E-12 iron homeostasis 3 6.33E-13
14 SGTC_263 alizarin 6.56 107.9 µM 1.08E-10 iron homeostasis 20 2.67E-11
15 SGTC_103 0844-0104 6.52 51.8 µM 1.43E-10 ERAD & cell cycle 67 3.60E-11
16 SGTC_2582 agaric acid 6.01 100.0 µM 3.09E-9 redox potentiating 160 9.41E-10
17 SGTC_1257 0669-0121 5.80 16.0 µM 1.00E-8 2 3.28E-9
18 SGTC_2586 curcumin 5.77 80.0 µM 1.22E-8 iron homeostasis 18 4.06E-9
19 SGTC_1230 0170-0365 5.61 3.8 µM 2.94E-8 endomembrane recycling 26 1.03E-8
20 SGTC_1110 3-hydroxy-3'-methoxyflavone 5.58 1.2 µM 3.40E-8 iron homeostasis 17 1.20E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.655 0 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.492 9.92E-204 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.451 1.11E-167 YER145C FTR1 hom High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress
0.392 1.76E-123 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.384 1.64E-118 YNL259C ATX1 hom Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
0.362 9.51E-105 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.356 7.85E-101 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.299 3.05E-70 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.267 4.89E-56 YMR057C_d YMR057C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
0.267 5.92E-56 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.256 3.73E-51 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.244 1.21E-46 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.224 1.69E-39 YOR178C GAC1 hom Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
0.217 6.38E-37 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.215 1.89E-36 YDR256C CTA1 hom Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation