YMR059W / SEN15

Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR059W / SEN15

Click on Significant Values for Screen Details ID:SGTC_361|Compound:000s-0510|FD-Score:-2.83|P-value:6.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.77|P-value:8.48E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.48|P-value:4.02E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.72|P-value:9.25E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.11|P-value:2.15E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-2.96|P-value:3.62E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-4.46|P-value:1.74E-7 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.15|P-value:1.56E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.85|P-value:5.39E-6 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.49|P-value:3.41E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.01|P-value:2.90E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.86|P-value:5.46E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.77|P-value:9.39E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:-2.71|P-value:9.58E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-2.97|P-value:3.35E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.35|P-value:3.96E-7 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.00|P-value:3.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.49|P-value:3.31E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:2.75|P-value:9.21E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.05|P-value:2.69E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.75|P-value:9.30E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-2.99|P-value:3.19E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.12|P-value:1.79E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.88|P-value:5.37E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.62|P-value:2.03E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.01|P-value:3.26E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-2.85|P-value:5.48E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.53|P-value:3.05E-5 ID:SGTC_2257|Compound:7960413|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.74|P-value:9.74E-6 ID:SGTC_2334|Compound:9017922|FD-Score:-3.17|P-value:1.44E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:4.60E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.83|P-value:6.11E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.00|P-value:3.39E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.39|P-value:5.38E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.81|P-value:7.60E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-8.21|P-value:4.11E-21 ID:SGTC_2854|Compound:9024559|FD-Score:3.86|P-value:5.83E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-2.75|P-value:8.40E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.09|P-value:2.06E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.31|P-value:8.88E-5 ID:SGTC_2986|Compound:9022445|FD-Score:2.74|P-value:9.53E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.12|P-value:2.03E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.87|P-value:5.20E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.32|P-value:8.28E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.14|P-value:1.67E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:-2.83|P-value:6.12E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:2.77|P-value:8.48E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.48|P-value:4.02E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:-2.72|P-value:9.25E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.11|P-value:2.15E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-2.96|P-value:3.62E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-4.46|P-value:1.74E-7 ID:SGTC_421|Compound:streptovitacin|FD-Score:-3.15|P-value:1.56E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.85|P-value:5.39E-6 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.49|P-value:3.41E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.01|P-value:2.90E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.86|P-value:5.46E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:3.77|P-value:9.39E-6 ID:SGTC_825|Compound:1988-2224|FD-Score:-2.71|P-value:9.58E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:-2.97|P-value:3.35E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:4.35|P-value:3.96E-7 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.00|P-value:3.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.49|P-value:3.31E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:2.75|P-value:9.21E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.05|P-value:2.69E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:2.75|P-value:9.30E-4 ID:SGTC_1329|Compound:1447-1697|FD-Score:-2.99|P-value:3.19E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:-3.12|P-value:1.79E-4 ID:SGTC_1727|Compound:st034309|FD-Score:2.88|P-value:5.37E-4 ID:SGTC_1815|Compound:st051655|FD-Score:3.62|P-value:2.03E-5 ID:SGTC_1829|Compound:berberine|FD-Score:3.01|P-value:3.26E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-2.85|P-value:5.48E-4 ID:SGTC_1885|Compound:st057546|FD-Score:3.53|P-value:3.05E-5 ID:SGTC_2257|Compound:7960413|FD-Score:2.96|P-value:3.90E-4 ID:SGTC_2274|Compound:7947094|FD-Score:-3.74|P-value:9.74E-6 ID:SGTC_2334|Compound:9017922|FD-Score:-3.17|P-value:1.44E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.28|P-value:1.00E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.45|P-value:4.60E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.83|P-value:6.11E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.00|P-value:3.39E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.39|P-value:5.38E-5 ID:SGTC_2848|Compound:9016370|FD-Score:3.81|P-value:7.60E-6 ID:SGTC_2849|Compound:9019321|FD-Score:-8.21|P-value:4.11E-21 ID:SGTC_2854|Compound:9024559|FD-Score:3.86|P-value:5.83E-6 ID:SGTC_2925|Compound:9010536|FD-Score:-2.75|P-value:8.40E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.09|P-value:2.06E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.31|P-value:8.88E-5 ID:SGTC_2986|Compound:9022445|FD-Score:2.74|P-value:9.53E-4 ID:SGTC_3088|Compound:9117578|FD-Score:3.12|P-value:2.03E-4 ID:SGTC_3191|Compound:9110352|FD-Score:-2.87|P-value:5.20E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.32|P-value:8.28E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.14|P-value:1.67E-4

Top fitness defect scores for YMR059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_911 3456-4043 4.35 236.0 µM 3.96E-7 mitochondrial processes 8 6.85E-6 0.01
2 SGTC_2854 9024559 3.86 71.4 µM 5.83E-6 6 5.61E-5 0.01
3 SGTC_2848 9016370 3.81 26.0 µM 7.60E-6 5 6.90E-5 0.10
4 SGTC_824 1304-0008 3.77 100.0 µM 9.39E-6 DNA damage response 7 8.15E-5 0.03
5 SGTC_1815 st051655 3.62 58.2 µM 2.03E-5 TSC3-RPN4 19 1.49E-4 0.16
6 SGTC_1885 st057546 3.53 99.9 µM 3.05E-5 4 2.05E-4 0.03
7 SGTC_394 menadione 3.48 8.3 µM 4.02E-5 superoxide 9 2.55E-4 0.01
8 SGTC_2532 xanthone 3.45 78.9 µM 4.60E-5 5 2.83E-4 0.14
9 SGTC_3202 9113761 3.32 49.5 µM 8.28E-5 22 4.49E-4 0.02
10 SGTC_2968 9090663 3.31 33.4 µM 8.88E-5 20 4.75E-4 0.07
11 SGTC_2397 5161689 3.28 200.0 µM 1.00E-4 13 5.21E-4 0.29
12 SGTC_3088 9117578 3.12 49.5 µM 2.03E-4 amide catabolism 9 9.11E-4 0.02
13 SGTC_406 estrone 3.11 100.0 µM 2.15E-4 6 9.51E-4 0.01
14 SGTC_1134 3477-0009 3.05 42.5 µM 2.69E-4 26 0.00113 0.05
15 SGTC_1829 berberine 3.01 14.4 µM 3.26E-4 60S ribosome export 25 0.00132 0.00
16 SGTC_1041 0206-0046 3.00 107.0 µM 3.36E-4 12 0.00135 0.10
17 SGTC_2583 asiatic acid 3.00 100.0 µM 3.39E-4 23 0.00136 0.03
18 SGTC_2257 7960413 2.96 200.0 µM 3.90E-4 NEO1-PIK1 32 0.00152 0.01
19 SGTC_1727 st034309 2.88 9.9 µM 5.37E-4 37 0.00196 0.07
20 SGTC_374 0880-0231 2.77 82.3 µM 8.48E-4 iron homeostasis 28 0.00281 0.13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.29E-13 YJL033W HCA4 het DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
0.116 1.50E-11 YIL024C_p YIL024C_p hom Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
0.114 3.24E-11 YLR460C_p YLR460C_p hom Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine
0.114 3.93E-11 YKL154W SRP102 het Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
0.105 9.33E-10 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.104 1.54E-9 YDR368W YPR1 hom NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication
0.104 1.78E-9 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.102 3.19E-9 YKR037C SPC34 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
0.102 3.73E-9 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.099 8.38E-9 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.099 9.07E-9 YGR172C YIP1 het Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4
0.095 3.10E-8 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.093 5.85E-8 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.093 6.73E-8 YOR171C LCB4 hom Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
0.092 9.62E-8 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes