HIPHOP chemogenomics database

YMR066W / SOV1

Mitochondrial protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR066W / SOV1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR066W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1034	k072-0165	10.10	12.7 µM	7.80E-21	Golgi	2	2.89E-24
2	SGTC_3194	9111903	9.48	49.5 µM	1.41E-18		1	1.33E-21
3	SGTC_1039	k821-0043	8.52	94.0 µM	2.33E-15	Golgi	2	8.23E-18
4	SGTC_3197	9113331	8.13	49.5 µM	3.63E-14		1	2.09E-16
5	SGTC_236	1509-0011	6.53	5.3 µM	9.31E-10		275	3.25E-11
6	SGTC_1916	st067606	5.78	49.2 µM	5.38E-8		9	3.84E-9
7	SGTC_727	3032-0951	5.75	202.0 µM	6.15E-8		9	4.49E-9
8	SGTC_2001	4023502	5.41	57.7 µM	3.24E-7	mitochondrial processes	3	3.16E-8
9	SGTC_1622	st003707	5.38	19.4 µM	3.78E-7	calcium & mitochondrial duress	13	3.80E-8
10	SGTC_2013	4024628	5.34	200.0 µM	4.41E-7		23	4.56E-8
11	SGTC_310	1273-0058	5.23	1.1 µM	7.35E-7	mitochondrial stress	175	8.30E-8
12	SGTC_173	1273-0061	5.21	2.7 µM	8.06E-7	mitochondrial stress	139	9.25E-8
13	SGTC_314	1671-0008	5.04	2.7 µM	1.80E-6		22	2.37E-7
14	SGTC_2250	alverine citrate	4.84	130.0 µM	4.21E-6		100	6.45E-7
15	SGTC_1041	0206-0046	4.82	107.0 µM	4.69E-6		21	7.31E-7
16	SGTC_1426	4048-4480	4.72	71.7 µM	6.91E-6	60S ribosome export	6	1.15E-6
17	SGTC_3186	9110464	4.72	49.5 µM	7.07E-6	RPP1 & pyrimidine depletion	5	1.18E-6
18	SGTC_333	3486-0131	4.69	40.1 µM	7.95E-6	amide catabolism	3	1.36E-6
19	SGTC_1742	st038235	4.67	28.9 µM	8.61E-6	mitochondrial stress	89	1.49E-6
20	SGTC_717	1532-0246	4.58	73.2 µM	1.23E-5	Golgi	17	2.27E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.287	9.09E-65	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.284	2.65E-63	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.271	2.25E-57	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.265	3.54E-55	YOR205C	GEP3	hom	Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)
0.264	1.50E-54	YHR168W	MTG2	hom	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly
0.264	1.50E-54	YDL056W	MBP1	hom	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.263	2.64E-54	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.262	1.37E-53	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.260	4.32E-53	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.251	3.51E-49	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.250	6.19E-49	YDR296W	MHR1	hom	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.249	1.76E-48	YMR257C	PET111	hom	Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.248	4.55E-48	YLR439W	MRPL4	hom	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
0.246	1.71E-47	YMR293C	HER2	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
0.246	1.99E-47	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation