YMR070W / MOT3

Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcriptional regulation of CWP2 and other genes; can form the [MOT3+] prion

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR070W / MOT3

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:14.20|P-value:1.06E-37 ID:SGTC_18|Compound:0111-0177|FD-Score:8.70|P-value:2.80E-15 ID:SGTC_23|Compound:0213-0011|FD-Score:3.69|P-value:4.89E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.63|P-value:5.97E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.13|P-value:1.11E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.21|P-value:8.24E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:6.20|P-value:1.37E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:11.60|P-value:9.66E-26 ID:SGTC_137|Compound:0438-0332|FD-Score:4.72|P-value:1.19E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.67|P-value:1.47E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.63|P-value:1.32E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:3.71|P-value:4.61E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.33|P-value:5.30E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:7.53|P-value:6.93E-12 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.41|P-value:9.59E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.01|P-value:2.74E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.77|P-value:3.75E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.43|P-value:3.72E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.54|P-value:7.87E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.83|P-value:3.11E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.06|P-value:1.43E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.77|P-value:3.75E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.62|P-value:6.16E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.55|P-value:2.31E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.17|P-value:1.83E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.91|P-value:2.40E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.91|P-value:2.39E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.40|P-value:6.50E-7 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.43|P-value:8.83E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:6.62|P-value:1.49E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:7.61|P-value:4.24E-12 ID:SGTC_805|Compound:3852-0218|FD-Score:5.16|P-value:1.93E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:5.25|P-value:1.30E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.56|P-value:7.46E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.72|P-value:4.42E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.46|P-value:9.96E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.58|P-value:6.88E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.15|P-value:2.03E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:6.77|P-value:6.21E-10 ID:SGTC_1226|Compound:3909-7979|FD-Score:7.57|P-value:5.49E-12 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.50|P-value:8.80E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:8.20|P-value:9.33E-14 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.51|P-value:8.75E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.53|P-value:8.06E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.46|P-value:9.96E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.64|P-value:4.59E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.60|P-value:5.33E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.48|P-value:7.74E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.70|P-value:4.82E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.23|P-value:7.87E-5 ID:SGTC_1941|Compound:st076221|FD-Score:5.95|P-value:4.78E-8 ID:SGTC_2038|Compound:4100038|FD-Score:6.10|P-value:2.29E-8 ID:SGTC_2085|Compound:5307070|FD-Score:4.67|P-value:1.46E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.67|P-value:5.28E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.68|P-value:1.07E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.71|P-value:3.75E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.45|P-value:3.45E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.52|P-value:2.64E-5 ID:SGTC_2425|Compound:5628681|FD-Score:4.00|P-value:1.76E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.63|P-value:5.88E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.09|P-value:1.27E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.07|P-value:2.83E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.52|P-value:6.80E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.13|P-value:1.12E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.26|P-value:1.26E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:15.20|P-value:9.09E-43 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.52|P-value:8.47E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.23|P-value:1.14E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:8.51E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.57|P-value:7.07E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.97|P-value:4.27E-6 ID:SGTC_2846|Compound:9008642|FD-Score:-3.48|P-value:7.75E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.46|P-value:3.25E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-9.10|P-value:9.14E-17 ID:SGTC_2962|Compound:9082311|FD-Score:4.26|P-value:6.94E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.91|P-value:2.37E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.71|P-value:3.71E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.38|P-value:3.44E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-7.40|P-value:1.04E-11 ID:SGTC_3174|Compound:9107204|FD-Score:3.50|P-value:8.82E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:14.20|P-value:1.06E-37 ID:SGTC_18|Compound:0111-0177|FD-Score:8.70|P-value:2.80E-15 ID:SGTC_23|Compound:0213-0011|FD-Score:3.69|P-value:4.89E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.63|P-value:5.97E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.13|P-value:1.11E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.21|P-value:8.24E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:6.20|P-value:1.37E-8 ID:SGTC_103|Compound:0844-0104|FD-Score:11.60|P-value:9.66E-26 ID:SGTC_137|Compound:0438-0332|FD-Score:4.72|P-value:1.19E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:4.67|P-value:1.47E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.63|P-value:1.32E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:3.71|P-value:4.61E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.33|P-value:5.30E-5 ID:SGTC_258|Compound:haloperidol|FD-Score:7.53|P-value:6.93E-12 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.41|P-value:9.59E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.01|P-value:2.74E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.77|P-value:3.75E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.43|P-value:3.72E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:3.54|P-value:7.87E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.83|P-value:3.11E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.06|P-value:1.43E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:3.77|P-value:3.75E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.62|P-value:6.16E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.55|P-value:2.31E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.17|P-value:1.83E-6 ID:SGTC_572|Compound:0960-0087|FD-Score:3.91|P-value:2.40E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:3.91|P-value:2.39E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:5.40|P-value:6.50E-7 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.43|P-value:8.83E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:6.62|P-value:1.49E-9 ID:SGTC_690|Compound:glyoxal|FD-Score:7.61|P-value:4.24E-12 ID:SGTC_805|Compound:3852-0218|FD-Score:5.16|P-value:1.93E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:5.25|P-value:1.30E-6 ID:SGTC_998|Compound:3996-0085|FD-Score:3.56|P-value:7.46E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.72|P-value:4.42E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.46|P-value:9.96E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:3.58|P-value:6.88E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.15|P-value:2.03E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:6.77|P-value:6.21E-10 ID:SGTC_1226|Compound:3909-7979|FD-Score:7.57|P-value:5.49E-12 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.50|P-value:8.80E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:8.20|P-value:9.33E-14 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.51|P-value:8.75E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.53|P-value:8.06E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.46|P-value:9.96E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-3.64|P-value:4.59E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.60|P-value:5.33E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.48|P-value:7.74E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.70|P-value:4.82E-4 ID:SGTC_1893|Compound:st059353|FD-Score:4.23|P-value:7.87E-5 ID:SGTC_1941|Compound:st076221|FD-Score:5.95|P-value:4.78E-8 ID:SGTC_2038|Compound:4100038|FD-Score:6.10|P-value:2.29E-8 ID:SGTC_2085|Compound:5307070|FD-Score:4.67|P-value:1.46E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.67|P-value:5.28E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.68|P-value:1.07E-5 ID:SGTC_2358|Compound:9037157|FD-Score:-3.71|P-value:3.75E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.45|P-value:3.45E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.52|P-value:2.64E-5 ID:SGTC_2425|Compound:5628681|FD-Score:4.00|P-value:1.76E-4 ID:SGTC_2430|Compound:5571206|FD-Score:3.63|P-value:5.88E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:4.09|P-value:1.27E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.07|P-value:2.83E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-3.52|P-value:6.80E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.13|P-value:1.12E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:5.26|P-value:1.26E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:15.20|P-value:9.09E-43 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.52|P-value:8.47E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:6.23|P-value:1.14E-8 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.51|P-value:8.51E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.57|P-value:7.07E-4 ID:SGTC_2841|Compound:9004761|FD-Score:4.97|P-value:4.27E-6 ID:SGTC_2846|Compound:9008642|FD-Score:-3.48|P-value:7.75E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.46|P-value:3.25E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-9.10|P-value:9.14E-17 ID:SGTC_2962|Compound:9082311|FD-Score:4.26|P-value:6.94E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.91|P-value:2.37E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-3.71|P-value:3.71E-4 ID:SGTC_3037|Compound:9091026|FD-Score:-4.38|P-value:3.44E-5 ID:SGTC_3077|Compound:9117319|FD-Score:-7.40|P-value:1.04E-11 ID:SGTC_3174|Compound:9107204|FD-Score:3.50|P-value:8.82E-4

Top fitness defect scores for YMR070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 15.20 5.0 µM 9.09E-43 4 2.21E-52
2 SGTC_8 0354-0001 14.20 70.0 µM 1.06E-37 2 3.86E-46
3 SGTC_103 0844-0104 11.60 51.8 µM 9.66E-26 ERAD & cell cycle 21 2.11E-31
4 SGTC_18 0111-0177 8.70 500.0 nM 2.80E-15 6 1.64E-18
5 SGTC_1304 1165-0502 8.20 251.0 µM 9.33E-14 17 1.23E-16
6 SGTC_690 glyoxal 7.61 20.3 µM 4.24E-12 30 1.36E-14
7 SGTC_1226 3909-7979 7.57 35.4 µM 5.49E-12 9 1.87E-14
8 SGTC_258 haloperidol 7.53 50.8 µM 6.93E-12 fatty acid desaturase (OLE1) 7 2.48E-14
9 SGTC_1191 1487-1166 6.77 10.6 µM 6.21E-10 azole & statin 6 6.30E-12
10 SGTC_683 panaxydol 6.62 45.0 µM 1.49E-9 sphingolipid biosynthesis & PDR1 13 1.85E-11
11 SGTC_2679 rapamycin 6.23 1.0 nM 1.14E-8 71 2.27E-10
12 SGTC_87 0100-0052 6.20 35.5 µM 1.37E-8 29 2.85E-10
13 SGTC_2038 4100038 6.10 31.0 µM 2.29E-8 plasma membrane duress 22 5.34E-10
14 SGTC_1941 st076221 5.95 61.8 µM 4.78E-8 sphingolipid biosynthesis & PDR1 32 1.32E-9
15 SGTC_625 k213-0058 5.40 121.0 µM 6.50E-7 translation 49 3.28E-8
16 SGTC_2619 obliquin 5.26 87.9 µM 1.26E-6 cell wall 90 7.37E-8
17 SGTC_955 1216-0110 5.25 33.0 µM 1.30E-6 sphingolipid biosynthesis & PDR1 41 7.67E-8
18 SGTC_568 1193-0097 5.17 7.5 µM 1.83E-6 ERAD & cell cycle 80 1.17E-7
19 SGTC_805 3852-0218 5.16 479.0 µM 1.93E-6 ERAD & cell cycle 32 1.25E-7
20 SGTC_1161 k007-0610 5.15 110.0 µM 2.03E-6 ERAD & cell cycle 77 1.33E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.372 1.00E-110 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.354 1.29E-99 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.288 3.75E-65 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.287 8.64E-65 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.270 4.65E-57 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.236 7.15E-44 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.234 5.24E-43 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.234 7.20E-43 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.232 5.14E-42 YGR055W MUP1 hom High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
0.222 7.86E-39 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.220 3.98E-38 YPR120C CLB5 hom B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
0.209 1.61E-34 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.191 7.38E-29 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.191 7.53E-29 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.190 1.56E-28 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA