HIPHOP chemogenomics database

YMR072W / ABF2

Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR072W / ABF2

Click on Significant Values for Screen Details

Top fitness defect scores for YMR072W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	19.20	5.3 µM	4.57E-82		61	1.59E-82
2	SGTC_173	1273-0061	11.30	2.7 µM	1.23E-29	mitochondrial stress	30	7.90E-30
3	SGTC_310	1273-0058	10.50	1.1 µM	4.36E-26	mitochondrial stress	35	2.93E-26
4	SGTC_520	3584-0023	8.12	682.0 µM	3.01E-16		2	2.30E-16
5	SGTC_275	trichlorophene	7.85	5.7 µM	2.61E-15	mitochondrial stress	78	2.02E-15
6	SGTC_386	1509-0011	7.34	3.1 µM	1.39E-13		74	1.11E-13
7	SGTC_70	0141-0289	6.64	43.3 µM	1.88E-11	mitochondrial stress	59	1.54E-11
8	SGTC_1964	st076914	5.82	61.0 µM	3.56E-9	RPP1 & pyrimidine depletion	2	3.02E-9
9	SGTC_519	k048-0011	5.52	62.8 µM	1.98E-8		3	1.70E-8
10	SGTC_2016	5121758	5.43	140.0 µM	3.30E-8	redox potentiating	16	2.83E-8
11	SGTC_1742	st038235	4.92	28.9 µM	4.97E-7	mitochondrial stress	78	4.35E-7
12	SGTC_998	3996-0085	4.88	177.0 µM	6.20E-7		6	5.43E-7
13	SGTC_2561	acetosyringone	4.74	100.0 µM	1.24E-6		9	1.09E-6
14	SGTC_63	0099-0242	4.71	26.7 µM	1.43E-6	mitochondrial stress	66	1.27E-6
15	SGTC_314	1671-0008	4.63	2.7 µM	2.07E-6		29	1.83E-6
16	SGTC_3013	9080133	4.62	71.4 µM	2.15E-6		8	1.90E-6
17	SGTC_1887	st057648	4.58	70.8 µM	2.58E-6		2	2.28E-6
18	SGTC_596	1155-0152	4.55	116.0 µM	3.07E-6	TRP & mitochondrial translation	23	2.73E-6
19	SGTC_530	4358-1714	4.43	28.0 µM	5.20E-6		32	4.63E-6
20	SGTC_778	3456-2434	4.35	196.0 µM	7.52E-6	mitochondrial response to ROS	63	6.71E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.535	1.37E-247	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.523	1.62E-235	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.515	1.14E-225	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.511	1.48E-222	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.502	6.58E-214	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.497	8.94E-209	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.493	3.62E-205	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.490	4.87E-202	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.489	7.95E-201	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.485	7.15E-198	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.474	4.96E-188	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.466	7.53E-181	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.457	5.69E-173	YDR079W	PET100	hom	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.457	1.69E-172	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.454	2.28E-170	YDR268W	MSW1	hom	Mitochondrial tryptophanyl-tRNA synthetase