YMR072W / ABF2

Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR072W / ABF2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.53|P-value:2.24E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.12|P-value:9.66E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.71|P-value:1.43E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:6.64|P-value:1.88E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:3.24|P-value:6.41E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.30|P-value:1.23E-29 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.10|P-value:9.35E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.20|P-value:4.57E-82 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.85|P-value:2.61E-15 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.38|P-value:3.50E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.50|P-value:4.36E-26 ID:SGTC_314|Compound:1671-0008|FD-Score:4.63|P-value:2.07E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:3.34|P-value:4.55E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.19|P-value:1.32E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.34|P-value:1.39E-13 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.06|P-value:6.45E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.78|P-value:7.48E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.65|P-value:1.26E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:5.52|P-value:1.98E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:8.12|P-value:3.01E-16 ID:SGTC_530|Compound:4358-1714|FD-Score:4.43|P-value:5.20E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:4.55|P-value:3.07E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.44|P-value:3.15E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.41|P-value:3.53E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.23|P-value:6.07E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.43|P-value:2.94E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.97|P-value:3.91E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.67|P-value:1.35E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.35|P-value:7.52E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:3.17|P-value:8.25E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.64|P-value:1.49E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.51|P-value:2.46E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:4.88|P-value:6.20E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.04|P-value:3.02E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.26|P-value:6.13E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.33|P-value:8.36E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.15|P-value:8.72E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.10|P-value:9.44E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.46|P-value:2.57E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.14|P-value:8.27E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.17|P-value:8.12E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:8.12E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.92|P-value:4.97E-7 ID:SGTC_1754|Compound:st042065|FD-Score:-3.47|P-value:2.49E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.98|P-value:1.12E-9 ID:SGTC_1796|Compound:st049173|FD-Score:3.72|P-value:1.10E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.55|P-value:2.11E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.58|P-value:2.58E-6 ID:SGTC_1959|Compound:st077091|FD-Score:-3.18|P-value:7.19E-4 ID:SGTC_1964|Compound:st076914|FD-Score:5.82|P-value:3.56E-9 ID:SGTC_1967|Compound:st070177|FD-Score:3.86|P-value:6.36E-5 ID:SGTC_2016|Compound:5121758|FD-Score:5.43|P-value:3.30E-8 ID:SGTC_2021|Compound:4019055|FD-Score:-5.51|P-value:1.78E-8 ID:SGTC_2024|Compound:5144227|FD-Score:-3.78|P-value:7.62E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.77|P-value:8.86E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.95|P-value:4.40E-5 ID:SGTC_2183|Compound:6420625|FD-Score:4.09|P-value:2.35E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.53|P-value:2.23E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.53|P-value:2.28E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.84|P-value:6.03E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.71|P-value:1.13E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.27|P-value:5.26E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.27|P-value:5.75E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.29|P-value:5.46E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.77|P-value:9.08E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.41|P-value:3.49E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.58|P-value:2.21E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.08|P-value:2.47E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.86|P-value:5.72E-7 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.74|P-value:1.24E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.87|P-value:6.12E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.38|P-value:3.47E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-5.31|P-value:5.43E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.83|P-value:7.13E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:-3.13|P-value:8.54E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.43|P-value:3.27E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.31|P-value:9.23E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-3.13|P-value:8.52E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.47|P-value:3.84E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-3.98|P-value:3.30E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.86|P-value:5.76E-7 ID:SGTC_2939|Compound:9044578|FD-Score:-4.76|P-value:9.23E-7 ID:SGTC_2940|Compound:9060638|FD-Score:3.86|P-value:6.24E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-4.85|P-value:5.95E-7 ID:SGTC_3013|Compound:9080133|FD-Score:4.62|P-value:2.15E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.85|P-value:5.75E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-4.49|P-value:3.41E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:3.53|P-value:2.24E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.12|P-value:9.66E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:4.71|P-value:1.43E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:6.64|P-value:1.88E-11 ID:SGTC_119|Compound:0121-0043|FD-Score:3.24|P-value:6.41E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.30|P-value:1.23E-29 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.10|P-value:9.35E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:19.20|P-value:4.57E-82 ID:SGTC_275|Compound:trichlorophene|FD-Score:7.85|P-value:2.61E-15 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.38|P-value:3.50E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:10.50|P-value:4.36E-26 ID:SGTC_314|Compound:1671-0008|FD-Score:4.63|P-value:2.07E-6 ID:SGTC_343|Compound:4130-2827|FD-Score:3.34|P-value:4.55E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-4.19|P-value:1.32E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.54|P-value:2.22E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:7.34|P-value:1.39E-13 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.46|P-value:2.90E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-6.06|P-value:6.45E-10 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.78|P-value:7.48E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.65|P-value:1.26E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:5.52|P-value:1.98E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:8.12|P-value:3.01E-16 ID:SGTC_530|Compound:4358-1714|FD-Score:4.43|P-value:5.20E-6 ID:SGTC_596|Compound:1155-0152|FD-Score:4.55|P-value:3.07E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.44|P-value:3.15E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.41|P-value:3.53E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:-3.23|P-value:6.07E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-3.43|P-value:2.94E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.97|P-value:3.91E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:3.59|P-value:1.79E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:3.67|P-value:1.35E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.35|P-value:7.52E-6 ID:SGTC_886|Compound:0866-0150|FD-Score:3.17|P-value:8.25E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.64|P-value:1.49E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:3.51|P-value:2.46E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:4.88|P-value:6.20E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:4.04|P-value:3.02E-5 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:3.26|P-value:6.13E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.33|P-value:8.36E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.15|P-value:8.72E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.10|P-value:9.44E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:-3.46|P-value:2.57E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.14|P-value:8.27E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.17|P-value:8.12E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:8.12E-5 ID:SGTC_1742|Compound:st038235|FD-Score:4.92|P-value:4.97E-7 ID:SGTC_1754|Compound:st042065|FD-Score:-3.47|P-value:2.49E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.98|P-value:1.12E-9 ID:SGTC_1796|Compound:st049173|FD-Score:3.72|P-value:1.10E-4 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:3.55|P-value:2.11E-4 ID:SGTC_1887|Compound:st057648|FD-Score:4.58|P-value:2.58E-6 ID:SGTC_1959|Compound:st077091|FD-Score:-3.18|P-value:7.19E-4 ID:SGTC_1964|Compound:st076914|FD-Score:5.82|P-value:3.56E-9 ID:SGTC_1967|Compound:st070177|FD-Score:3.86|P-value:6.36E-5 ID:SGTC_2016|Compound:5121758|FD-Score:5.43|P-value:3.30E-8 ID:SGTC_2021|Compound:4019055|FD-Score:-5.51|P-value:1.78E-8 ID:SGTC_2024|Compound:5144227|FD-Score:-3.78|P-value:7.62E-5 ID:SGTC_2112|Compound:5488546|FD-Score:3.77|P-value:8.86E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.95|P-value:4.40E-5 ID:SGTC_2183|Compound:6420625|FD-Score:4.09|P-value:2.35E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.53|P-value:2.23E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.53|P-value:2.28E-4 ID:SGTC_2322|Compound:7413319|FD-Score:-3.84|P-value:6.03E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.71|P-value:1.13E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-3.27|P-value:5.26E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.27|P-value:5.75E-4 ID:SGTC_2471|Compound:5466956|FD-Score:3.29|P-value:5.46E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.77|P-value:9.08E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.43|P-value:3.23E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.41|P-value:3.49E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-4.58|P-value:2.21E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.08|P-value:2.47E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-4.86|P-value:5.72E-7 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.74|P-value:1.24E-6 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.87|P-value:6.12E-5 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-3.38|P-value:3.47E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-5.31|P-value:5.43E-8 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.83|P-value:7.13E-5 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:-3.13|P-value:8.54E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.43|P-value:3.27E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.31|P-value:9.23E-6 ID:SGTC_2836|Compound:9010338|FD-Score:-3.13|P-value:8.52E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.47|P-value:3.84E-6 ID:SGTC_2869|Compound:9037858|FD-Score:-3.98|P-value:3.30E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.86|P-value:5.76E-7 ID:SGTC_2939|Compound:9044578|FD-Score:-4.76|P-value:9.23E-7 ID:SGTC_2940|Compound:9060638|FD-Score:3.86|P-value:6.24E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-4.85|P-value:5.95E-7 ID:SGTC_3013|Compound:9080133|FD-Score:4.62|P-value:2.15E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.85|P-value:5.75E-5 ID:SGTC_3110|Compound:9122132|FD-Score:-4.49|P-value:3.41E-6

Top fitness defect scores for YMR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 19.20 5.3 µM 4.57E-82 61 1.59E-82
2 SGTC_173 1273-0061 11.30 2.7 µM 1.23E-29 mitochondrial stress 30 7.90E-30
3 SGTC_310 1273-0058 10.50 1.1 µM 4.36E-26 mitochondrial stress 35 2.93E-26
4 SGTC_520 3584-0023 8.12 682.0 µM 3.01E-16 2 2.30E-16
5 SGTC_275 trichlorophene 7.85 5.7 µM 2.61E-15 mitochondrial stress 78 2.02E-15
6 SGTC_386 1509-0011 7.34 3.1 µM 1.39E-13 74 1.11E-13
7 SGTC_70 0141-0289 6.64 43.3 µM 1.88E-11 mitochondrial stress 59 1.54E-11
8 SGTC_1964 st076914 5.82 61.0 µM 3.56E-9 RPP1 & pyrimidine depletion 2 3.02E-9
9 SGTC_519 k048-0011 5.52 62.8 µM 1.98E-8 3 1.70E-8
10 SGTC_2016 5121758 5.43 140.0 µM 3.30E-8 redox potentiating 16 2.83E-8
11 SGTC_1742 st038235 4.92 28.9 µM 4.97E-7 mitochondrial stress 78 4.35E-7
12 SGTC_998 3996-0085 4.88 177.0 µM 6.20E-7 6 5.43E-7
13 SGTC_2561 acetosyringone 4.74 100.0 µM 1.24E-6 9 1.09E-6
14 SGTC_63 0099-0242 4.71 26.7 µM 1.43E-6 mitochondrial stress 66 1.27E-6
15 SGTC_314 1671-0008 4.63 2.7 µM 2.07E-6 29 1.83E-6
16 SGTC_3013 9080133 4.62 71.4 µM 2.15E-6 8 1.90E-6
17 SGTC_1887 st057648 4.58 70.8 µM 2.58E-6 2 2.28E-6
18 SGTC_596 1155-0152 4.55 116.0 µM 3.07E-6 TRP & mitochondrial translation 23 2.73E-6
19 SGTC_530 4358-1714 4.43 28.0 µM 5.20E-6 32 4.63E-6
20 SGTC_778 3456-2434 4.35 196.0 µM 7.52E-6 mitochondrial response to ROS 63 6.71E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.535 1.37E-247 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.523 1.62E-235 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.515 1.14E-225 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.511 1.48E-222 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.502 6.58E-214 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.497 8.94E-209 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.493 3.62E-205 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.490 4.87E-202 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.489 7.95E-201 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.485 7.15E-198 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.474 4.96E-188 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.466 7.53E-181 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.457 5.69E-173 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.457 1.69E-172 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.454 2.28E-170 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase