HIPHOP chemogenomics database

YMR074C

Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR074C / YMR074C

Click on Significant Values for Screen Details

Top fitness defect scores for YMR074C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_656	4090-1979	7.36	187.0 µM	4.09E-16		2	9.47E-14
2	SGTC_666	0272-0154	6.56	136.0 µM	3.57E-13	cell wall	17	2.77E-11
3	SGTC_669	0108-0021	5.48	26.2 µM	1.01E-9	fatty acid desaturase (OLE1)	27	2.17E-8
4	SGTC_939	1165-0479	5.39	45.3 µM	1.76E-9		5	3.45E-8
5	SGTC_372	0155-0182	5.14	15.9 µM	9.19E-9	mitochondrial response to ROS	11	1.39E-7
6	SGTC_1525	8-methoxypsoralen	4.25	92.5 µM	1.60E-6	DNA damage response	20	1.06E-5
7	SGTC_1540	guanosine	4.15	70.6 µM	2.73E-6		6	1.66E-5
8	SGTC_2514	salinomycin	4.13	42.7 µM	3.00E-6		39	1.80E-5
9	SGTC_2284	7945075	4.03	39.2 µM	5.06E-6	mitochondrial processes	24	2.79E-5
10	SGTC_309	k408-0051	3.75	1.5 µM	1.98E-5		61	8.80E-5
11	SGTC_668	1682-0499	3.72	62.6 µM	2.25E-5		25	9.81E-5
12	SGTC_2763	lisinopril	3.34	49.3 µM	1.25E-4		20	4.15E-4
13	SGTC_2899	9053889	3.14	58.4 µM	2.91E-4		26	8.48E-4
14	SGTC_500	h-89	3.09	112.0 µM	3.52E-4	cell wall signaling	68	9.97E-4
15	SGTC_410	α-linolenic acid	3.01	100.0 µM	4.93E-4	excess fatty acid	68	0.00132
16	SGTC_2631	bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone	2.99	100.0 µM	5.22E-4		76	0.00139
17	SGTC_1333	1482-0047	2.94	286.0 µM	6.45E-4		65	0.00166
18	SGTC_3152	9099253	2.92	49.5 µM	6.87E-4	NEO1-PIK1	223	0.00176
19	SGTC_916	4466-0038	2.84	42.0 nM	9.22E-4	cell wall	165	0.00225
20	SGTC_1246	0422-0085	2.76	105.0 µM	0.00123		105	0.00286

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.295	1.97E-68	YNL218W	MGS1	hom	Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.281	8.86E-62	YDR169C	STB3	hom	Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.246	2.14E-47	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.230	2.31E-41	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.230	1.58E-41	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.228	6.21E-41	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.223	3.57E-39	YGR011W_d	YGR011W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.214	3.53E-36	YDL176W	YDL176W	hom	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.212	2.06E-35	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.200	9.60E-32	YBR274W	CHK1	hom	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.195	3.50E-30	YFL014W	HSP12	hom	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.192	4.19E-29	YJR137C	MET5	hom	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.189	1.75E-28	YFL051C_p	YFL051C_p	hom	Putative protein of unknown function; YFL051C is not an essential gene
0.189	2.43E-28	YGR136W	LSB1	hom	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.187	1.21E-27	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication