YMR085W_p

Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR085W / YMR085W

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:-3.40|P-value:2.85E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.90|P-value:5.45E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.44|P-value:3.19E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.35|P-value:7.63E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-4.35|P-value:5.54E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.50|P-value:2.63E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.91|P-value:5.22E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.29|P-value:4.27E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.84|P-value:5.11E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.98|P-value:3.90E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.98|P-value:3.82E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.07|P-value:9.23E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.13|P-value:9.54E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.87|P-value:6.07E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.52|P-value:2.43E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.22|P-value:7.05E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.17|P-value:1.68E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.28|P-value:5.68E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.94|P-value:4.60E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.21|P-value:7.26E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.28|P-value:5.77E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.32|P-value:5.04E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.53|P-value:2.33E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.11|P-value:2.23E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.17|P-value:8.40E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.18|P-value:6.24E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.10|P-value:2.29E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.32|P-value:5.00E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.89|P-value:5.70E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.71|P-value:1.14E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.41|P-value:2.72E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.39|P-value:3.91E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.55|P-value:2.13E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.50|P-value:2.55E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.17|P-value:1.24E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:7.42|P-value:6.96E-14 ID:SGTC_2805|Compound:7950783|FD-Score:4.41|P-value:5.74E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-3.34|P-value:3.60E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.91|P-value:5.14E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.40|P-value:2.85E-4 ID:SGTC_230|Compound:MPP+|FD-Score:3.90|P-value:5.45E-5 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:3.44|P-value:3.19E-4 ID:SGTC_251|Compound:melphalan|FD-Score:4.35|P-value:7.63E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:-4.35|P-value:5.54E-6 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.50|P-value:2.63E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.91|P-value:5.22E-5 ID:SGTC_587|Compound:k089-0003|FD-Score:-3.29|P-value:4.27E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:-3.84|P-value:5.11E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:3.98|P-value:3.90E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:3.98|P-value:3.82E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:3.42|P-value:3.49E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.07|P-value:9.23E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.13|P-value:9.54E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.87|P-value:6.07E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.52|P-value:2.43E-6 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.22|P-value:7.05E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.17|P-value:1.68E-5 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.28|P-value:5.68E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.94|P-value:4.60E-5 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.21|P-value:7.26E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.28|P-value:5.77E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.32|P-value:5.04E-4 ID:SGTC_1562|Compound:morin hydrate|FD-Score:3.53|P-value:2.33E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.52|P-value:2.41E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.11|P-value:2.23E-5 ID:SGTC_1916|Compound:st067606|FD-Score:3.17|P-value:8.40E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.18|P-value:6.24E-4 ID:SGTC_1933|Compound:st074711|FD-Score:4.10|P-value:2.29E-5 ID:SGTC_1936|Compound:st074407|FD-Score:3.32|P-value:5.00E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.89|P-value:5.70E-5 ID:SGTC_2057|Compound:5236571|FD-Score:3.71|P-value:1.14E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.41|P-value:2.72E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.57|P-value:2.03E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.39|P-value:3.91E-4 ID:SGTC_2463|Compound:5473429|FD-Score:3.55|P-value:2.13E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.50|P-value:2.55E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:-4.17|P-value:1.24E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:7.42|P-value:6.96E-14 ID:SGTC_2805|Compound:7950783|FD-Score:4.41|P-value:5.74E-6 ID:SGTC_2871|Compound:9038510|FD-Score:-3.34|P-value:3.60E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.91|P-value:5.14E-5

Top fitness defect scores for YMR085W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2768 sulfasalazine 7.42 50.2 µM 6.96E-14 2 5.97E-14
2 SGTC_2805 7950783 4.41 58.4 µM 5.74E-6 18 5.07E-6
3 SGTC_251 melphalan 4.35 456.5 µM 7.63E-6 DNA damage response 13 6.74E-6
4 SGTC_1067 clotrimazole 4.17 1.4 µM 1.68E-5 azole & statin 36 1.49E-5
5 SGTC_1581 himbacine 4.11 57.9 µM 2.23E-5 Golgi 50 1.98E-5
6 SGTC_1933 st074711 4.10 15.9 µM 2.29E-5 38 2.03E-5
7 SGTC_756 0508-1999 3.98 28.3 µM 3.82E-5 RPP1 & pyrimidine depletion 24 3.40E-5
8 SGTC_669 0108-0021 3.98 26.2 µM 3.90E-5 fatty acid desaturase (OLE1) 79 3.46E-5
9 SGTC_1203 3992-3522 3.94 103.0 µM 4.60E-5 34 4.09E-5
10 SGTC_3116 9124943 3.91 49.5 µM 5.14E-5 18 4.58E-5
11 SGTC_518 1021-0119 3.91 62.6 µM 5.22E-5 ERG2 38 4.64E-5
12 SGTC_230 MPP+ 3.90 141.7 µM 5.45E-5 15 4.85E-5
13 SGTC_2050 5263056 3.89 171.0 µM 5.70E-5 fatty acid desaturase (OLE1) 45 5.07E-5
14 SGTC_951 1171-0579 3.87 82.7 µM 6.07E-5 cell wall 87 5.40E-5
15 SGTC_2057 5236571 3.71 38.3 µM 1.14E-4 RPP1 & pyrimidine depletion 40 1.02E-4
16 SGTC_2157 5649910 3.57 96.4 µM 2.03E-4 31 1.82E-4
17 SGTC_2463 5473429 3.55 200.0 µM 2.13E-4 ERG2 26 1.91E-4
18 SGTC_1562 morin hydrate 3.53 59.1 µM 2.33E-4 27 2.09E-4
19 SGTC_1567 st069303 3.52 68.4 µM 2.41E-4 mitochondrial processes 33 2.16E-4
20 SGTC_2499 avocadenofuran 3.50 51.5 µM 2.55E-4 55 2.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 8.71E-11 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.097 2.10E-8 YDR308C SRB7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
0.093 7.09E-8 YOR298W MUM3 hom Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
0.089 2.24E-7 YMR189W GCV2 hom P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
0.088 3.37E-7 YOR307C SLY41 hom Protein involved in ER-to-Golgi transport
0.085 8.17E-7 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.083 1.67E-6 YGR273C_p YGR273C_p hom Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene
0.080 3.55E-6 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.080 3.66E-6 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.079 4.18E-6 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.079 4.76E-6 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.079 5.03E-6 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.078 5.37E-6 YJL125C GCD14 het Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
0.075 1.39E-5 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.074 1.66E-5 YGR244C LSC2 hom Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate