YMR089C / YTA12

Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR089C / YTA12

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.69|P-value:2.92E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.75|P-value:1.32E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.43|P-value:8.90E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:2.91|P-value:6.94E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.00|P-value:6.55E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.60|P-value:9.56E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.28|P-value:1.64E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:5.35|P-value:3.59E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.23|P-value:2.07E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.18|P-value:2.82E-6 ID:SGTC_317|Compound:4495-0002|FD-Score:2.82|P-value:9.83E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.30|P-value:3.81E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.20|P-value:2.32E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.16|P-value:2.97E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:3.64|P-value:3.57E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:2.94|P-value:6.25E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.44|P-value:8.62E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.35|P-value:1.25E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:2.83|P-value:9.46E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.58|P-value:4.76E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:3.71|P-value:2.63E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.30|P-value:1.51E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:2.89|P-value:7.48E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.57|P-value:9.60E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.89|P-value:7.61E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.05|P-value:5.25E-6 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.82|P-value:9.82E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:2.82|P-value:9.74E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.18|P-value:2.70E-6 ID:SGTC_1627|Compound:st003713|FD-Score:4.74|P-value:1.37E-7 ID:SGTC_1649|Compound:st011737|FD-Score:2.88|P-value:7.85E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.32|P-value:1.43E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.19|P-value:2.20E-14 ID:SGTC_1826|Compound:st055655|FD-Score:3.20|P-value:2.33E-4 ID:SGTC_1835|Compound:st008666|FD-Score:2.93|P-value:6.63E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.17|P-value:2.89E-6 ID:SGTC_1847|Compound:st056231|FD-Score:4.76|P-value:1.23E-7 ID:SGTC_1907|Compound:st060210|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.52|P-value:6.20E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.63|P-value:2.56E-7 ID:SGTC_2056|Compound:5235370|FD-Score:3.89|P-value:1.15E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.73|P-value:1.46E-7 ID:SGTC_2109|Compound:5483026|FD-Score:4.07|P-value:4.74E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.93|P-value:2.29E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.77|P-value:2.03E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.21|P-value:2.19E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.06|P-value:4.92E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.04|P-value:8.68E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.43|P-value:7.58E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.39|P-value:2.24E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-4.01|P-value:1.55E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.60|P-value:4.19E-5 ID:SGTC_2570|Compound:licareol|FD-Score:7.69|P-value:6.03E-17 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.29|P-value:1.58E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.76|P-value:2.09E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.10|P-value:3.47E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.21|P-value:2.23E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.53|P-value:5.76E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.06|P-value:7.98E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.00|P-value:5.07E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.84|P-value:3.41E-5 ID:SGTC_3227|Compound:9130768|FD-Score:2.96|P-value:5.93E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-4.16|P-value:7.70E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:3.69|P-value:2.92E-5 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.75|P-value:1.32E-7 ID:SGTC_118|Compound:0083-0097|FD-Score:3.43|P-value:8.90E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:2.91|P-value:6.94E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:4.00|P-value:6.55E-6 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.60|P-value:9.56E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:4.28|P-value:1.64E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:5.35|P-value:3.59E-9 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.23|P-value:2.07E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:4.18|P-value:2.82E-6 ID:SGTC_317|Compound:4495-0002|FD-Score:2.82|P-value:9.83E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.30|P-value:3.81E-6 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.20|P-value:2.32E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:4.16|P-value:2.97E-6 ID:SGTC_744|Compound:1594-0068|FD-Score:3.64|P-value:3.57E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:2.94|P-value:6.25E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.44|P-value:8.62E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:3.35|P-value:1.25E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:2.83|P-value:9.46E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.58|P-value:4.76E-5 ID:SGTC_899|Compound:1083-0020|FD-Score:3.71|P-value:2.63E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.30|P-value:1.51E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:2.89|P-value:7.48E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.57|P-value:9.60E-7 ID:SGTC_1131|Compound:3454-3128|FD-Score:2.89|P-value:7.61E-4 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.05|P-value:5.25E-6 ID:SGTC_1437|Compound:4092-1038|FD-Score:2.82|P-value:9.82E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:2.82|P-value:9.74E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.18|P-value:2.70E-6 ID:SGTC_1627|Compound:st003713|FD-Score:4.74|P-value:1.37E-7 ID:SGTC_1649|Compound:st011737|FD-Score:2.88|P-value:7.85E-4 ID:SGTC_1695|Compound:st026914|FD-Score:3.32|P-value:1.43E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-7.19|P-value:2.20E-14 ID:SGTC_1826|Compound:st055655|FD-Score:3.20|P-value:2.33E-4 ID:SGTC_1835|Compound:st008666|FD-Score:2.93|P-value:6.63E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.17|P-value:2.89E-6 ID:SGTC_1847|Compound:st056231|FD-Score:4.76|P-value:1.23E-7 ID:SGTC_1907|Compound:st060210|FD-Score:3.35|P-value:1.28E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.52|P-value:6.20E-5 ID:SGTC_2053|Compound:5265679|FD-Score:4.63|P-value:2.56E-7 ID:SGTC_2056|Compound:5235370|FD-Score:3.89|P-value:1.15E-5 ID:SGTC_2057|Compound:5236571|FD-Score:4.73|P-value:1.46E-7 ID:SGTC_2109|Compound:5483026|FD-Score:4.07|P-value:4.74E-6 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-3.93|P-value:2.29E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.77|P-value:2.03E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.21|P-value:2.19E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.06|P-value:4.92E-6 ID:SGTC_2270|Compound:7924575|FD-Score:-3.04|P-value:8.68E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.43|P-value:7.58E-7 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.39|P-value:2.24E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:-4.01|P-value:1.55E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.60|P-value:4.19E-5 ID:SGTC_2570|Compound:licareol|FD-Score:7.69|P-value:6.03E-17 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.29|P-value:1.58E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.76|P-value:2.09E-5 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.10|P-value:3.47E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.21|P-value:2.23E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.53|P-value:5.76E-5 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.06|P-value:7.98E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.00|P-value:5.07E-4 ID:SGTC_3015|Compound:9080845|FD-Score:-3.84|P-value:3.41E-5 ID:SGTC_3227|Compound:9130768|FD-Score:2.96|P-value:5.93E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-4.16|P-value:7.70E-6

Top fitness defect scores for YMR089C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2570 licareol 7.69 100.0 µM 6.03E-17 1 7.09E-15
2 SGTC_236 1509-0011 5.35 5.3 µM 3.59E-9 308 4.45E-8
3 SGTC_1847 st056231 4.76 15.0 µM 1.23E-7 18 9.75E-7
4 SGTC_28 pentachloropyridine N-oxide 4.75 1.6 µM 1.32E-7 TSC3-RPN4 36 1.04E-6
5 SGTC_1627 st003713 4.74 25.6 µM 1.37E-7 calcium & mitochondrial duress 47 1.07E-6
6 SGTC_2057 5236571 4.73 38.3 µM 1.46E-7 RPP1 & pyrimidine depletion 15 1.13E-6
7 SGTC_2053 5265679 4.63 138.0 µM 2.56E-7 10 1.84E-6
8 SGTC_2277 7947813 4.43 106.9 µM 7.58E-7 RSC complex & mRNA processing 18 4.75E-6
9 SGTC_173 1273-0061 4.28 2.7 µM 1.64E-6 mitochondrial stress 174 9.28E-6
10 SGTC_1622 st003707 4.18 19.4 µM 2.70E-6 calcium & mitochondrial duress 28 1.43E-5
11 SGTC_314 1671-0008 4.18 2.7 µM 2.82E-6 44 1.49E-5
12 SGTC_1836 st055642 4.17 81.0 µM 2.89E-6 15 1.52E-5
13 SGTC_527 4476-4215 4.16 268.0 µM 2.97E-6 PDR1 28 1.56E-5
14 SGTC_2109 5483026 4.07 200.0 µM 4.74E-6 RSC complex & mRNA processing 23 2.34E-5
15 SGTC_2233 sulbentine 4.06 40.4 µM 4.92E-6 60 2.42E-5
16 SGTC_1189 1431-2119 4.05 7.3 µM 5.25E-6 22 2.56E-5
17 SGTC_131 0141-0277 4.00 33.9 µM 6.55E-6 36 3.10E-5
18 SGTC_2056 5235370 3.89 200.0 µM 1.15E-5 41 5.08E-5
19 SGTC_2120 5538279 3.77 152.0 µM 2.03E-5 22 8.30E-5
20 SGTC_2600 tangeritin 3.76 88.0 µM 2.09E-5 39 8.53E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.322 1.07E-81 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.312 1.43E-76 YJL096W MRPL49 hom Mitochondrial ribosomal protein of the large subunit
0.298 5.13E-70 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.291 1.56E-66 YDL056W MBP1 hom Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes
0.282 1.79E-62 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.282 2.69E-62 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.280 3.25E-61 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.279 3.33E-61 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.279 7.37E-61 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.278 2.10E-60 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.277 4.00E-60 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.277 6.06E-60 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.276 9.69E-60 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.274 8.17E-59 YKL169C_d YKL169C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38
0.274 8.84E-59 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD