HIPHOP chemogenomics database
YMR093W / UTP15 
Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YMR093W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.174 | 4.55E-24 | YNL178W | RPS3 | het | Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 |
| 0.162 | 4.44E-21 | YHR196W | UTP9 | het | Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA |
| 0.158 | 3.14E-20 | YGL123W | RPS2 | het | Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 |
| 0.146 | 2.44E-17 | YDR398W | UTP5 | het | Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit |
| 0.140 | 3.86E-16 | YDR064W | RPS13 | het | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 |
| 0.130 | 3.62E-14 | YPR136C_d | YPR136C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 |
| 0.122 | 1.51E-12 | YOL040C | RPS15 | het | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 |
| 0.117 | 1.14E-11 | YJR007W | SUI2 | het | Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress |
| 0.116 | 1.61E-11 | YER012W | PRE1 | het | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
| 0.116 | 1.74E-11 | YOR312C | RPL20B | hom | Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication |
| 0.113 | 6.96E-11 | YPR137W | RRP9 | het | Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein |
| 0.111 | 1.25E-10 | YHL015W | RPS20 | het | Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10 |
| 0.108 | 3.48E-10 | YDR324C | UTP4 | het | Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript |
| 0.107 | 5.20E-10 | YJL069C | UTP18 | het | Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data |
| 0.105 | 1.13E-9 | YOR210W | RPB10 | het | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |