YMR094W / CTF13

Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR094W / CTF13

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-2.80|P-value:3.38E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-2.60|P-value:8.20E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.13|P-value:7.74E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:2.59|P-value:8.98E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.91|P-value:2.21E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.99|P-value:1.44E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.01|P-value:1.38E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-2.97|P-value:1.55E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:2.75|P-value:4.49E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-2.73|P-value:4.65E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:2.92|P-value:2.13E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.60|P-value:8.66E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.85|P-value:2.81E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-2.85|P-value:2.73E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:2.75|P-value:4.50E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.10|P-value:8.78E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.62|P-value:7.65E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-2.60|P-value:8.15E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-2.75|P-value:4.31E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.19|P-value:5.99E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.78|P-value:3.72E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.69|P-value:5.80E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.66|P-value:6.21E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.10|P-value:9.06E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-2.94|P-value:1.86E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.11|P-value:8.20E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-2.70|P-value:5.37E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.57|P-value:9.71E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.58|P-value:1.61E-8 ID:SGTC_2018|Compound:5133068|FD-Score:-3.62|P-value:5.81E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-4.34|P-value:7.11E-8 ID:SGTC_2050|Compound:5263056|FD-Score:3.34|P-value:2.77E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-2.60|P-value:8.00E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.96|P-value:1.67E-4 ID:SGTC_2591|Compound:skatole|FD-Score:2.65|P-value:6.85E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.99|P-value:7.25E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.50|P-value:1.21E-5 ID:SGTC_2800|Compound:7887935|FD-Score:2.75|P-value:4.45E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.06|P-value:1.03E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.22|P-value:4.78E-5 ID:SGTC_3016|Compound:9080866|FD-Score:-3.00|P-value:1.37E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.63|P-value:5.88E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-2.65|P-value:6.46E-4 ID:SGTC_3168|Compound:9103419|FD-Score:2.80|P-value:3.65E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.23|P-value:4.77E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-2.82|P-value:3.16E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.48|P-value:1.35E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-2.80|P-value:3.38E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-2.60|P-value:8.20E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.13|P-value:7.74E-5 ID:SGTC_326|Compound:k292-0812|FD-Score:2.59|P-value:8.98E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:2.91|P-value:2.21E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-2.99|P-value:1.44E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.01|P-value:1.38E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:-2.97|P-value:1.55E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:2.75|P-value:4.49E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:-2.73|P-value:4.65E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:2.92|P-value:2.13E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:2.60|P-value:8.66E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-2.85|P-value:2.81E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:-2.85|P-value:2.73E-4 ID:SGTC_1235|Compound:benzylparaben|FD-Score:2.75|P-value:4.50E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:-3.10|P-value:8.78E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:2.62|P-value:7.65E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-2.60|P-value:8.15E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-2.75|P-value:4.31E-4 ID:SGTC_1434|Compound:4073-0095|FD-Score:3.19|P-value:5.99E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-2.78|P-value:3.72E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:2.69|P-value:5.80E-4 ID:SGTC_1674|Compound:st016616|FD-Score:-2.66|P-value:6.21E-4 ID:SGTC_1685|Compound:st024049|FD-Score:3.10|P-value:9.06E-5 ID:SGTC_1705|Compound:st027868|FD-Score:-2.94|P-value:1.86E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.11|P-value:8.20E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-2.70|P-value:5.37E-4 ID:SGTC_2002|Compound:4023503|FD-Score:2.57|P-value:9.71E-4 ID:SGTC_2013|Compound:4024628|FD-Score:4.58|P-value:1.61E-8 ID:SGTC_2018|Compound:5133068|FD-Score:-3.62|P-value:5.81E-6 ID:SGTC_2023|Compound:5144124|FD-Score:-4.34|P-value:7.11E-8 ID:SGTC_2050|Compound:5263056|FD-Score:3.34|P-value:2.77E-5 ID:SGTC_2473|Compound:5854593|FD-Score:-2.60|P-value:8.00E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.96|P-value:1.67E-4 ID:SGTC_2591|Compound:skatole|FD-Score:2.65|P-value:6.85E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:3.99|P-value:7.25E-7 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.50|P-value:1.21E-5 ID:SGTC_2800|Compound:7887935|FD-Score:2.75|P-value:4.45E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-3.06|P-value:1.03E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.22|P-value:4.78E-5 ID:SGTC_3016|Compound:9080866|FD-Score:-3.00|P-value:1.37E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.63|P-value:5.88E-6 ID:SGTC_3153|Compound:9100258|FD-Score:-2.65|P-value:6.46E-4 ID:SGTC_3168|Compound:9103419|FD-Score:2.80|P-value:3.65E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.23|P-value:4.77E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-2.82|P-value:3.16E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.48|P-value:1.35E-5

Top fitness defect scores for YMR094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2013 4024628 4.58 200.0 µM 1.61E-8 8 2.37E-6 0.56
2 SGTC_2620 irigenin 3.99 100.0 µM 7.25E-7 14 3.33E-5 0.03
3 SGTC_3080 9117754 3.63 49.5 µM 5.88E-6 7 1.43E-4 0.12
4 SGTC_2758 dehydroepiandrosterone 3.50 69.3 µM 1.21E-5 10 2.36E-4 0.03
5 SGTC_3328 9140624 3.48 29.0 µM 1.35E-5 7 2.55E-4 0.07
6 SGTC_2050 5263056 3.34 171.0 µM 2.77E-5 fatty acid desaturase (OLE1) 37 4.22E-4 0.03
7 SGTC_3181 9108277 3.23 49.5 µM 4.77E-5 iron homeostasis 19 6.17E-4 0.08
8 SGTC_1434 4073-0095 3.19 163.0 µM 5.99E-5 7 7.23E-4 0.06
9 SGTC_163 1327-0036 3.13 7.5 µM 7.74E-5 66 8.66E-4 0.04
10 SGTC_1685 st024049 3.10 53.1 µM 9.06E-5 TSC3-RPN4 7 9.67E-4 0.02
11 SGTC_866 0495-0101 3.01 262.0 µM 1.38E-4 60S ribosome export 16 0.00130 0.05
12 SGTC_1057 3448-5381 2.92 134.0 µM 2.13E-4 calcium & mitochondrial duress 30 0.00176 0.03
13 SGTC_399 oxolinic acid 2.91 75.0 µM 2.21E-4 11 0.00181 0.08
14 SGTC_3168 9103419 2.80 49.5 µM 3.65E-4 60S ribosome export 6 0.00257 0.16
15 SGTC_2800 7887935 2.75 81.8 µM 4.45E-4 RPP1 & pyrimidine depletion 27 0.00296 0.03
16 SGTC_876 0720-0963 2.75 56.8 µM 4.49E-4 15 0.00298 0.03
17 SGTC_1235 benzylparaben 2.75 21.5 µM 4.50E-4 19 0.00298 5.96E-4
18 SGTC_1525 8-methoxypsoralen 2.69 92.5 µM 5.80E-4 DNA damage response 47 0.00356 0.04
19 SGTC_2591 skatole 2.65 100.0 µM 6.85E-4 27 0.00401 0.12
20 SGTC_1251 0490-5699 2.62 265.0 µM 7.65E-4 27 0.00433 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.198 4.05E-31 YDR331W GPI8 het ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
0.129 5.46E-14 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.127 1.57E-13 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.127 1.83E-13 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.125 3.65E-13 YPL151C PRP46 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs
0.122 1.11E-12 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.122 1.27E-12 YDL004W ATP16 het Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
0.119 3.91E-12 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.119 4.25E-12 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.117 1.00E-11 YGL015C_p YGL015C_p hom Putative protein of unknown function; null mutants accumulate cargo in the Golgi
0.117 1.09E-11 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.117 1.32E-11 YFL020C PAU5 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme
0.113 5.49E-11 YHR014W SPO13 hom Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
0.111 1.08E-10 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.108 3.59E-10 YIL164C NIT1 hom Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene