HIPHOP chemogenomics database

YMR095C / SNO1

Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR095C / SNO1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR095C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_945	3381-0768	5.84	11.3 µM	2.71E-11	endomembrane recycling	8	2.64E-9
2	SGTC_2814	7977482	5.09	43.0 µM	5.24E-9		18	1.77E-7
3	SGTC_2602	kawain	5.00	100.0 µM	9.38E-9		10	2.82E-7
4	SGTC_1508	1080-0625	4.72	72.9 µM	5.47E-8		7	1.15E-6
5	SGTC_939	1165-0479	4.55	45.3 µM	1.62E-7		14	2.75E-6
6	SGTC_1176	0848-0131	4.32	83.3 µM	6.11E-7	Golgi	17	7.96E-6
7	SGTC_2536	dehydroabietamide	3.69	32.0 µM	1.65E-5		44	1.12E-4
8	SGTC_946	3434-1334	3.64	87.4 µM	2.12E-5		40	1.37E-4
9	SGTC_2791	5663188	3.59	71.4 µM	2.66E-5	RPP1 & pyrimidine depletion	34	1.64E-4
10	SGTC_884	0851-0618	3.59	334.0 µM	2.71E-5		23	1.66E-4
11	SGTC_3018	9082602	3.52	49.5 µM	3.73E-5		58	2.15E-4
12	SGTC_1678	st019265	3.46	80.2 µM	5.03E-5	60S ribosome export	38	2.74E-4
13	SGTC_2621	lithochol-11-enic acid	3.34	100.0 µM	8.57E-5		54	4.20E-4
14	SGTC_2624	nerol	3.25	100.0 µM	1.28E-4		28	5.81E-4
15	SGTC_2125	5246583	3.17	200.0 µM	1.83E-4	tubulin folding & SWR complex	88	7.72E-4
16	SGTC_2819	7996655	3.15	46.4 µM	1.98E-4		50	8.24E-4
17	SGTC_1866	st057638	3.07	64.0 µM	2.75E-4		40	0.00107
18	SGTC_1035	k081-0041	3.05	55.2 µM	3.01E-4	Golgi	65	0.00115
19	SGTC_798	1287-0182	2.90	476.0 µM	5.38E-4		77	0.00184
20	SGTC_2820	7989630	2.90	71.4 µM	5.54E-4	ERG2	66	0.00189

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.282	1.86E-62	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.198	5.35E-31	YAL045C_d	YAL045C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.197	1.18E-30	YLR097C	HRT3	hom	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.195	3.03E-30	YLR363W-A	YLR363W-A	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.190	1.19E-28	YKL171W	NNK1	hom	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.180	8.23E-26	YLL012W	YEH1	hom	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.174	4.36E-24	YFL063W_d	YFL063W_d	hom	Dubious open reading frame, based on available experimental and comparative sequence data
0.165	5.66E-22	YDR139C	RUB1	hom	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.161	5.79E-21	YOR163W	DDP1	hom	Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.158	4.51E-20	YKL220C	FRE2	hom	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.154	3.68E-19	YOL141W	PPM2	hom	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.153	6.27E-19	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.147	9.30E-18	YKR023W_p	YKR023W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.146	1.75E-17	YOR238W_p	YOR238W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.145	2.49E-17	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture