YMR095C / SNO1

Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR095C / SNO1

Click on Significant Values for Screen Details ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.91|P-value:5.74E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-4.21|P-value:1.29E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-2.88|P-value:6.58E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.43|P-value:3.61E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.43|P-value:6.50E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.90|P-value:5.38E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.59|P-value:2.71E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.55|P-value:1.62E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:5.84|P-value:2.71E-11 ID:SGTC_946|Compound:3434-1334|FD-Score:3.64|P-value:2.12E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.05|P-value:3.01E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.63|P-value:1.16E-7 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.32|P-value:6.11E-7 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.87|P-value:6.92E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.80|P-value:9.01E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.72|P-value:5.47E-8 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.26|P-value:1.38E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.46|P-value:5.03E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.07|P-value:2.75E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.39|P-value:7.55E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.76|P-value:9.29E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.62|P-value:2.66E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.59|P-value:1.48E-7 ID:SGTC_2048|Compound:5246248|FD-Score:2.79|P-value:8.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.91|P-value:2.00E-8 ID:SGTC_2125|Compound:5246583|FD-Score:3.17|P-value:1.83E-4 ID:SGTC_2201|Compound:6605497|FD-Score:2.80|P-value:8.07E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.69|P-value:1.65E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.78|P-value:9.46E-4 ID:SGTC_2602|Compound:kawain|FD-Score:5.00|P-value:9.38E-9 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.34|P-value:8.57E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.25|P-value:1.28E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.59|P-value:2.66E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.09|P-value:5.24E-9 ID:SGTC_2819|Compound:7996655|FD-Score:3.15|P-value:1.98E-4 ID:SGTC_2820|Compound:7989630|FD-Score:2.90|P-value:5.54E-4 ID:SGTC_3001|Compound:9076041|FD-Score:2.76|P-value:9.25E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.52|P-value:3.73E-5 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.91|P-value:5.74E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-4.21|P-value:1.29E-6 ID:SGTC_531|Compound:3788-1495|FD-Score:-2.88|P-value:6.58E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.43|P-value:3.61E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:-3.43|P-value:6.50E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:2.90|P-value:5.38E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:3.59|P-value:2.71E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:4.55|P-value:1.62E-7 ID:SGTC_945|Compound:3381-0768|FD-Score:5.84|P-value:2.71E-11 ID:SGTC_946|Compound:3434-1334|FD-Score:3.64|P-value:2.12E-5 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.05|P-value:3.01E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.63|P-value:1.16E-7 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.32|P-value:6.11E-7 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-2.87|P-value:6.92E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.80|P-value:9.01E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.72|P-value:5.47E-8 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.26|P-value:1.38E-4 ID:SGTC_1678|Compound:st019265|FD-Score:3.46|P-value:5.03E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.07|P-value:2.75E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.39|P-value:7.55E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.76|P-value:9.29E-4 ID:SGTC_1925|Compound:st057770|FD-Score:-3.62|P-value:2.66E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.59|P-value:1.48E-7 ID:SGTC_2048|Compound:5246248|FD-Score:2.79|P-value:8.25E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-4.91|P-value:2.00E-8 ID:SGTC_2125|Compound:5246583|FD-Score:3.17|P-value:1.83E-4 ID:SGTC_2201|Compound:6605497|FD-Score:2.80|P-value:8.07E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:3.69|P-value:1.65E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.78|P-value:9.46E-4 ID:SGTC_2602|Compound:kawain|FD-Score:5.00|P-value:9.38E-9 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.34|P-value:8.57E-5 ID:SGTC_2624|Compound:nerol|FD-Score:3.25|P-value:1.28E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.59|P-value:2.66E-5 ID:SGTC_2814|Compound:7977482|FD-Score:5.09|P-value:5.24E-9 ID:SGTC_2819|Compound:7996655|FD-Score:3.15|P-value:1.98E-4 ID:SGTC_2820|Compound:7989630|FD-Score:2.90|P-value:5.54E-4 ID:SGTC_3001|Compound:9076041|FD-Score:2.76|P-value:9.25E-4 ID:SGTC_3018|Compound:9082602|FD-Score:3.52|P-value:3.73E-5

Top fitness defect scores for YMR095C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_945 3381-0768 5.84 11.3 µM 2.71E-11 endomembrane recycling 8 2.64E-9
2 SGTC_2814 7977482 5.09 43.0 µM 5.24E-9 18 1.77E-7
3 SGTC_2602 kawain 5.00 100.0 µM 9.38E-9 10 2.82E-7
4 SGTC_1508 1080-0625 4.72 72.9 µM 5.47E-8 7 1.15E-6
5 SGTC_939 1165-0479 4.55 45.3 µM 1.62E-7 14 2.75E-6
6 SGTC_1176 0848-0131 4.32 83.3 µM 6.11E-7 Golgi 17 7.96E-6
7 SGTC_2536 dehydroabietamide 3.69 32.0 µM 1.65E-5 44 1.12E-4
8 SGTC_946 3434-1334 3.64 87.4 µM 2.12E-5 40 1.37E-4
9 SGTC_2791 5663188 3.59 71.4 µM 2.66E-5 RPP1 & pyrimidine depletion 34 1.64E-4
10 SGTC_884 0851-0618 3.59 334.0 µM 2.71E-5 23 1.66E-4
11 SGTC_3018 9082602 3.52 49.5 µM 3.73E-5 58 2.15E-4
12 SGTC_1678 st019265 3.46 80.2 µM 5.03E-5 60S ribosome export 38 2.74E-4
13 SGTC_2621 lithochol-11-enic acid 3.34 100.0 µM 8.57E-5 54 4.20E-4
14 SGTC_2624 nerol 3.25 100.0 µM 1.28E-4 28 5.81E-4
15 SGTC_2125 5246583 3.17 200.0 µM 1.83E-4 tubulin folding & SWR complex 88 7.72E-4
16 SGTC_2819 7996655 3.15 46.4 µM 1.98E-4 50 8.24E-4
17 SGTC_1866 st057638 3.07 64.0 µM 2.75E-4 40 0.00107
18 SGTC_1035 k081-0041 3.05 55.2 µM 3.01E-4 Golgi 65 0.00115
19 SGTC_798 1287-0182 2.90 476.0 µM 5.38E-4 77 0.00184
20 SGTC_2820 7989630 2.90 71.4 µM 5.54E-4 ERG2 66 0.00189

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.282 1.86E-62 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.198 5.35E-31 YAL045C_d YAL045C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.197 1.18E-30 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.195 3.03E-30 YLR363W-A YLR363W-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress
0.190 1.19E-28 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.180 8.23E-26 YLL012W YEH1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.174 4.36E-24 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.165 5.66E-22 YDR139C RUB1 hom Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)
0.161 5.79E-21 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.158 4.51E-20 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.154 3.68E-19 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.153 6.27E-19 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.147 9.30E-18 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.146 1.75E-17 YOR238W_p YOR238W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.145 2.49E-17 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture