YMR105C / PGM2

Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR105C / PGM2

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:4.05|P-value:3.02E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.81|P-value:8.70E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-2.93|P-value:4.85E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.58|P-value:2.77E-5 ID:SGTC_458|Compound:nppb|FD-Score:2.87|P-value:7.01E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.94|P-value:5.26E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.08|P-value:2.98E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.24|P-value:1.30E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.19|P-value:1.88E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.12|P-value:2.54E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.22|P-value:1.68E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.13|P-value:2.13E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-3.01|P-value:3.45E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.98|P-value:3.89E-6 ID:SGTC_1924|Compound:st058459|FD-Score:3.96|P-value:4.83E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-3.85|P-value:7.38E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.49|P-value:4.97E-5 ID:SGTC_1971|Compound:st069429|FD-Score:2.85|P-value:7.56E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.40|P-value:6.46E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.11|P-value:2.64E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-4.27|P-value:7.75E-7 ID:SGTC_2318|Compound:6029776|FD-Score:3.09|P-value:2.88E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.79|P-value:1.18E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.78|P-value:9.77E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.87|P-value:6.79E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.85|P-value:7.65E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.45|P-value:6.00E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.38|P-value:5.14E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:3.53|P-value:4.04E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.92|P-value:5.74E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.01|P-value:3.87E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-2.88|P-value:5.88E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.10|P-value:2.45E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.78|P-value:8.69E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.52|P-value:4.39E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:4.05|P-value:3.02E-6 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:2.81|P-value:8.70E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-2.93|P-value:4.85E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.58|P-value:2.77E-5 ID:SGTC_458|Compound:nppb|FD-Score:2.87|P-value:7.01E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:2.94|P-value:5.26E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.08|P-value:2.98E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.24|P-value:1.30E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.19|P-value:1.88E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.12|P-value:2.54E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.22|P-value:1.68E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.13|P-value:2.13E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-3.01|P-value:3.45E-4 ID:SGTC_1782|Compound:st039423|FD-Score:-3.98|P-value:3.89E-6 ID:SGTC_1924|Compound:st058459|FD-Score:3.96|P-value:4.83E-6 ID:SGTC_1925|Compound:st057770|FD-Score:-3.85|P-value:7.38E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.49|P-value:4.97E-5 ID:SGTC_1971|Compound:st069429|FD-Score:2.85|P-value:7.56E-4 ID:SGTC_2280|Compound:7785178|FD-Score:-3.40|P-value:6.46E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.11|P-value:2.64E-4 ID:SGTC_2291|Compound:7917025|FD-Score:-4.27|P-value:7.75E-7 ID:SGTC_2318|Compound:6029776|FD-Score:3.09|P-value:2.88E-4 ID:SGTC_2324|Compound:6149169|FD-Score:3.79|P-value:1.18E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:2.78|P-value:9.77E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:2.87|P-value:6.79E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.85|P-value:7.65E-6 ID:SGTC_2586|Compound:curcumin|FD-Score:3.45|P-value:6.00E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:4.38|P-value:5.14E-7 ID:SGTC_2606|Compound:farnesol|FD-Score:3.53|P-value:4.04E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.92|P-value:5.74E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:4.01|P-value:3.87E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-2.88|P-value:5.88E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.10|P-value:2.45E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-2.78|P-value:8.69E-4 ID:SGTC_3318|Compound:9139014|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.52|P-value:4.39E-5

Top fitness defect scores for YMR105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2605 digitonin 4.38 300.0 nM 5.14E-7 17 6.02E-6
2 SGTC_73 0327-0325 4.05 16.2 µM 3.02E-6 DNA damage response 47 2.51E-5
3 SGTC_2616 abietic acid 4.01 100.0 µM 3.87E-6 29 3.07E-5
4 SGTC_1924 st058459 3.96 75.1 µM 4.83E-6 10 3.67E-5
5 SGTC_2324 6149169 3.79 200.0 µM 1.18E-5 22 7.57E-5
6 SGTC_2606 farnesol 3.53 9.8 µM 4.04E-5 31 2.05E-4
7 SGTC_3320 9137005 3.52 35.1 µM 4.39E-5 endomembrane recycling 25 2.19E-4
8 SGTC_1935 st074532 3.49 41.6 µM 4.97E-5 53 2.42E-4
9 SGTC_2586 curcumin 3.45 80.0 µM 6.00E-5 iron homeostasis 78 2.82E-4
10 SGTC_3318 9139014 3.30 38.6 µM 1.19E-4 33 4.92E-4
11 SGTC_1525 8-methoxypsoralen 3.22 92.5 µM 1.68E-4 DNA damage response 66 6.51E-4
12 SGTC_979 1426-2828 3.19 121.0 µM 1.88E-4 52 7.13E-4
13 SGTC_1096 rimcazole 3.12 32.2 µM 2.54E-4 35 9.10E-4
14 SGTC_2288 7946289 3.11 167.3 µM 2.64E-4 72 9.36E-4
15 SGTC_2318 6029776 3.09 164.0 µM 2.88E-4 70 0.00101
16 SGTC_882 0843-0131 3.08 351.0 µM 2.98E-4 49 0.00104
17 SGTC_798 1287-0182 2.94 476.0 µM 5.26E-4 73 0.00164
18 SGTC_2608 thymoquinone 2.92 42.7 µM 5.74E-4 63 0.00176
19 SGTC_2574 2',4'-dihydroxychalcone 2.87 14.6 µM 6.79E-4 69 0.00202
20 SGTC_458 nppb 2.87 133.0 µM 7.01E-4 55 0.00208

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.196 3.09E-30 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.176 8.73E-25 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.153 5.34E-19 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.122 1.58E-12 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.121 1.67E-12 YLR013W GAT3 hom Protein containing GATA family zinc finger motifs
0.121 1.88E-12 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.121 2.32E-12 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.120 2.55E-12 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.117 1.18E-11 YJR011C_p YJR011C_p hom Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
0.117 1.39E-11 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.109 2.82E-10 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.106 6.65E-10 YBR227C MCX1 hom Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins
0.105 1.11E-9 YOR287C RRP36 het Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
0.104 1.59E-9 YPL112C PEX25 hom Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
0.102 2.83E-9 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene