YMR107W / SPG4

Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR107W / SPG4

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.16|P-value:1.75E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.36|P-value:4.12E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:4.74|P-value:4.86E-8 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.83|P-value:6.80E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.84|P-value:6.62E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.75|P-value:9.25E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.61|P-value:2.43E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:4.10|P-value:2.03E-6 ID:SGTC_534|Compound:k292-0788|FD-Score:3.14|P-value:2.04E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.08|P-value:2.44E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.36|P-value:7.85E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.90|P-value:5.46E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.00|P-value:3.38E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.19|P-value:1.53E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.36|P-value:7.77E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.06|P-value:2.93E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.36|P-value:3.62E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.71|P-value:5.24E-8 ID:SGTC_1906|Compound:st060206|FD-Score:3.53|P-value:3.59E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.23|P-value:1.39E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.05|P-value:3.07E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.18|P-value:1.61E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.93|P-value:4.97E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.70|P-value:6.18E-8 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.98|P-value:4.10E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.28|P-value:1.12E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.02|P-value:3.18E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.72|P-value:1.45E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.63|P-value:2.05E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.19|P-value:1.66E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.29|P-value:1.08E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.30|P-value:1.05E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.86|P-value:6.62E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.16|P-value:1.75E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-4.36|P-value:4.12E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:4.74|P-value:4.86E-8 ID:SGTC_184|Compound:1494-0393|FD-Score:-2.83|P-value:6.80E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-2.84|P-value:6.62E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-2.75|P-value:9.25E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.61|P-value:2.43E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:4.10|P-value:2.03E-6 ID:SGTC_534|Compound:k292-0788|FD-Score:3.14|P-value:2.04E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.08|P-value:2.44E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.36|P-value:7.85E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:2.90|P-value:5.46E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.00|P-value:3.38E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.19|P-value:1.53E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.36|P-value:7.77E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.06|P-value:2.93E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.36|P-value:3.62E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.71|P-value:5.24E-8 ID:SGTC_1906|Compound:st060206|FD-Score:3.53|P-value:3.59E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.23|P-value:1.39E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.05|P-value:3.07E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.18|P-value:1.61E-4 ID:SGTC_2458|Compound:5808907|FD-Score:2.93|P-value:4.97E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.70|P-value:6.18E-8 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.98|P-value:4.10E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:3.28|P-value:1.12E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.02|P-value:3.18E-4 ID:SGTC_2810|Compound:7959871|FD-Score:3.72|P-value:1.45E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.63|P-value:2.05E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.19|P-value:1.66E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.29|P-value:1.08E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.30|P-value:1.05E-4 ID:SGTC_3313|Compound:9133968|FD-Score:2.86|P-value:6.62E-4

Top fitness defect scores for YMR107W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_180 1486-1293 4.74 102.8 µM 4.86E-8 26 1.08E-6
2 SGTC_2487 5918373 4.70 44.0 µM 6.18E-8 5 1.31E-6
3 SGTC_438 sphingosine 4.10 6.7 µM 2.03E-6 17 2.10E-5
4 SGTC_1131 3454-3128 4.00 32.3 µM 3.38E-6 45 3.16E-5
5 SGTC_2810 7959871 3.72 45.5 µM 1.45E-5 copper-dependent oxidative stress 46 1.01E-4
6 SGTC_416 estradiol valerate 3.61 100.0 µM 2.43E-5 22 1.52E-4
7 SGTC_1906 st060206 3.53 94.7 µM 3.59E-5 30 2.08E-4
8 SGTC_1262 0737-0114 3.36 49.6 µM 7.77E-5 47 3.85E-4
9 SGTC_1125 tnp00248 3.36 1.3 µM 7.85E-5 65 3.88E-4
10 SGTC_3310 9130229 3.30 44.1 µM 1.05E-4 Golgi 53 4.89E-4
11 SGTC_3309 9129340 3.29 25.8 µM 1.08E-4 38 5.00E-4
12 SGTC_2563 tomatine 3.28 8.5 µM 1.12E-4 85 5.17E-4
13 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.23 70.1 µM 1.39E-4 64 6.12E-4
14 SGTC_2917 7979103 3.19 53.8 µM 1.66E-4 67 7.06E-4
15 SGTC_534 k292-0788 3.14 63.4 µM 2.04E-4 mitochondrial processes 57 8.33E-4
16 SGTC_1312 1218-2183 3.06 165.0 µM 2.93E-4 28 0.00111
17 SGTC_1937 st074714 3.05 47.2 µM 3.07E-4 79 0.00116
18 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 2.98 100.0 µM 4.10E-4 63 0.00146
19 SGTC_2458 5808907 2.93 16.4 µM 4.97E-4 30 0.00170
20 SGTC_1130 3454-2858 2.90 15.9 µM 5.46E-4 NEO1 144 0.00184

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.349 1.11E-96 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.299 3.16E-70 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.296 5.09E-69 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.279 5.66E-61 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.277 2.70E-60 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.274 2.41E-58 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.269 1.77E-56 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.263 2.17E-54 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.258 3.48E-52 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.249 1.46E-48 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.242 4.14E-46 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.239 7.31E-45 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.236 9.66E-44 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.233 1.42E-42 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.230 1.73E-41 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress