YMR110C / HFD1

Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR110C / HFD1

Click on Significant Values for Screen Details ID:SGTC_27|Compound:0485-0001|FD-Score:3.03|P-value:3.46E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.06|P-value:3.08E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:7.32|P-value:1.03E-16 ID:SGTC_64|Compound:000l-0018|FD-Score:10.10|P-value:7.01E-30 ID:SGTC_65|Compound:0798-0905|FD-Score:2.78|P-value:9.12E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:19.90|P-value:6.32E-111 ID:SGTC_86|Compound:0417-1630|FD-Score:5.70|P-value:8.09E-11 ID:SGTC_137|Compound:0438-0332|FD-Score:5.40|P-value:6.84E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:7.24|P-value:2.32E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:10.60|P-value:3.69E-33 ID:SGTC_200|Compound:k038-0079|FD-Score:5.44|P-value:5.29E-10 ID:SGTC_216|Compound:k038-0035|FD-Score:5.62|P-value:1.47E-10 ID:SGTC_284|Compound:0988-0104|FD-Score:4.28|P-value:7.88E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:3.48|P-value:4.93E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:5.93|P-value:1.39E-11 ID:SGTC_340|Compound:k038-0059|FD-Score:6.08|P-value:4.40E-12 ID:SGTC_367|Compound:0335-0881|FD-Score:4.62|P-value:1.13E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:2.82|P-value:7.90E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:6.64|P-value:4.72E-14 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.77|P-value:9.65E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.14|P-value:4.10E-9 ID:SGTC_635|Compound:k038-0028|FD-Score:3.63|P-value:2.39E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.19|P-value:1.29E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:6.19|P-value:1.93E-12 ID:SGTC_827|Compound:3253-0474|FD-Score:3.93|P-value:5.31E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.30|P-value:1.11E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.03|P-value:3.19E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.75|P-value:1.33E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.09|P-value:2.29E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.36|P-value:8.41E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.95|P-value:4.86E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.04|P-value:3.35E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.15|P-value:2.08E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-2.92|P-value:5.03E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.96|P-value:4.54E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.08|P-value:2.58E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.58|P-value:2.77E-5 ID:SGTC_1964|Compound:st076914|FD-Score:-4.51|P-value:1.87E-7 ID:SGTC_1974|Compound:st069448|FD-Score:6.47|P-value:1.86E-13 ID:SGTC_2028|Compound:5153890|FD-Score:-3.99|P-value:3.42E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.01|P-value:3.68E-4 ID:SGTC_2044|Compound:5102272|FD-Score:2.88|P-value:6.19E-4 ID:SGTC_2047|Compound:4141938|FD-Score:2.92|P-value:5.46E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.18|P-value:1.87E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-2.85|P-value:6.55E-4 ID:SGTC_2239|Compound:6685329|FD-Score:2.98|P-value:4.21E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.90|P-value:5.60E-6 ID:SGTC_2373|Compound:9071805|FD-Score:3.57|P-value:3.23E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.96|P-value:4.66E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.38|P-value:6.79E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.24|P-value:9.90E-7 ID:SGTC_2796|Compound:7949634|FD-Score:-2.80|P-value:7.82E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.51|P-value:4.10E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.10|P-value:2.54E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.56|P-value:2.98E-5 ID:SGTC_3295|Compound:9122362|FD-Score:-4.57|P-value:1.34E-7 ID:SGTC_3329|Compound:9141233|FD-Score:2.99|P-value:4.02E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:3.03|P-value:3.46E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.06|P-value:3.08E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:7.32|P-value:1.03E-16 ID:SGTC_64|Compound:000l-0018|FD-Score:10.10|P-value:7.01E-30 ID:SGTC_65|Compound:0798-0905|FD-Score:2.78|P-value:9.12E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:19.90|P-value:6.32E-111 ID:SGTC_86|Compound:0417-1630|FD-Score:5.70|P-value:8.09E-11 ID:SGTC_137|Compound:0438-0332|FD-Score:5.40|P-value:6.84E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:7.24|P-value:2.32E-16 ID:SGTC_158|Compound:k038-0087|FD-Score:10.60|P-value:3.69E-33 ID:SGTC_200|Compound:k038-0079|FD-Score:5.44|P-value:5.29E-10 ID:SGTC_216|Compound:k038-0035|FD-Score:5.62|P-value:1.47E-10 ID:SGTC_284|Compound:0988-0104|FD-Score:4.28|P-value:7.88E-7 ID:SGTC_291|Compound:4130-1278|FD-Score:3.48|P-value:4.93E-5 ID:SGTC_294|Compound:k038-0071|FD-Score:5.93|P-value:1.39E-11 ID:SGTC_340|Compound:k038-0059|FD-Score:6.08|P-value:4.40E-12 ID:SGTC_367|Compound:0335-0881|FD-Score:4.62|P-value:1.13E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:2.82|P-value:7.90E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:6.64|P-value:4.72E-14 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:2.77|P-value:9.65E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.14|P-value:4.10E-9 ID:SGTC_635|Compound:k038-0028|FD-Score:3.63|P-value:2.39E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:4.19|P-value:1.29E-6 ID:SGTC_794|Compound:k038-0031|FD-Score:6.19|P-value:1.93E-12 ID:SGTC_827|Compound:3253-0474|FD-Score:3.93|P-value:5.31E-6 ID:SGTC_846|Compound:0335-0850|FD-Score:3.30|P-value:1.11E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-3.03|P-value:3.19E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:3.75|P-value:1.33E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:4.09|P-value:2.29E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.36|P-value:8.41E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:2.95|P-value:4.86E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.04|P-value:3.35E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.15|P-value:2.08E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-2.92|P-value:5.03E-4 ID:SGTC_1426|Compound:4048-4480|FD-Score:2.96|P-value:4.54E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.08|P-value:2.58E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.58|P-value:2.77E-5 ID:SGTC_1964|Compound:st076914|FD-Score:-4.51|P-value:1.87E-7 ID:SGTC_1974|Compound:st069448|FD-Score:6.47|P-value:1.86E-13 ID:SGTC_2028|Compound:5153890|FD-Score:-3.99|P-value:3.42E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.01|P-value:3.68E-4 ID:SGTC_2044|Compound:5102272|FD-Score:2.88|P-value:6.19E-4 ID:SGTC_2047|Compound:4141938|FD-Score:2.92|P-value:5.46E-4 ID:SGTC_2048|Compound:5246248|FD-Score:3.18|P-value:1.87E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-2.85|P-value:6.55E-4 ID:SGTC_2239|Compound:6685329|FD-Score:2.98|P-value:4.21E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.90|P-value:5.60E-6 ID:SGTC_2373|Compound:9071805|FD-Score:3.57|P-value:3.23E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.96|P-value:4.66E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.38|P-value:6.79E-5 ID:SGTC_2477|Compound:5967686|FD-Score:-2.97|P-value:3.99E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.24|P-value:9.90E-7 ID:SGTC_2796|Compound:7949634|FD-Score:-2.80|P-value:7.82E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.51|P-value:4.10E-5 ID:SGTC_2934|Compound:9036370|FD-Score:3.10|P-value:2.54E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.56|P-value:2.98E-5 ID:SGTC_3295|Compound:9122362|FD-Score:-4.57|P-value:1.34E-7 ID:SGTC_3329|Compound:9141233|FD-Score:2.99|P-value:4.02E-4

Top fitness defect scores for YMR110C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_67 0335-0847 19.90 266.0 µM 6.32E-111 ubiquinone biosynthesis & proteasome 5 2.26E-88
2 SGTC_158 k038-0087 10.60 26.4 µM 3.69E-33 ubiquinone biosynthesis & proteasome 30 1.04E-26
3 SGTC_64 000l-0018 10.10 272.1 µM 7.01E-30 ubiquinone biosynthesis & proteasome 36 4.17E-24
4 SGTC_36 0335-0881 7.32 14.2 µM 1.03E-16 ubiquinone biosynthesis & proteasome 44 1.21E-13
5 SGTC_142 0335-0849 7.24 62.7 µM 2.32E-16 ubiquinone biosynthesis & proteasome 49 2.31E-13
6 SGTC_438 sphingosine 6.64 6.7 µM 4.72E-14 4 1.59E-11
7 SGTC_1974 st069448 6.47 26.9 µM 1.86E-13 1 4.75E-11
8 SGTC_794 k038-0031 6.19 316.0 µM 1.93E-12 ubiquinone biosynthesis & proteasome 54 3.06E-10
9 SGTC_340 k038-0059 6.08 454.0 µM 4.40E-12 ubiquinone biosynthesis & proteasome 20 5.90E-10
10 SGTC_294 k038-0071 5.93 157.0 µM 1.39E-11 ubiquinone biosynthesis & proteasome 16 1.47E-9
11 SGTC_86 0417-1630 5.70 471.9 µM 8.09E-11 ubiquinone biosynthesis & proteasome 91 6.00E-9
12 SGTC_216 k038-0035 5.62 28.4 µM 1.47E-10 ubiquinone biosynthesis & proteasome 28 9.68E-9
13 SGTC_200 k038-0079 5.44 37.5 µM 5.29E-10 ubiquinone biosynthesis & proteasome 34 2.69E-8
14 SGTC_137 0438-0332 5.40 85.4 µM 6.84E-10 ubiquinone biosynthesis & proteasome 69 3.30E-8
15 SGTC_514 4466-0038 5.14 2.6 nM 4.10E-9 cell wall 102 1.38E-7
16 SGTC_367 0335-0881 4.62 7.1 µM 1.13E-7 ubiquinone biosynthesis & proteasome 52 1.95E-6
17 SGTC_284 0988-0104 4.28 32.6 µM 7.88E-7 heme requiring 9 9.23E-6
18 SGTC_2582 agaric acid 4.24 100.0 µM 9.90E-7 redox potentiating 290 1.11E-5
19 SGTC_642 0335-0876 4.19 158.0 µM 1.29E-6 ubiquinone biosynthesis & proteasome 37 1.37E-5
20 SGTC_1091 telmisartan 4.09 47.6 µM 2.29E-6 9 2.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.665 0 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.634 0 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.577 4.71E-297 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.571 6.54E-290 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.570 5.45E-288 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.557 3.81E-273 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.555 2.90E-270 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.554 4.44E-269 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.536 1.18E-248 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.532 2.91E-244 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.526 3.10E-238 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.525 1.10E-236 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.512 1.10E-223 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.508 1.25E-219 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.492 1.93E-204 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)