YMR115W / MGR3

Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR115W / MGR3

Click on Significant Values for Screen Details ID:SGTC_163|Compound:1327-0036|FD-Score:3.84|P-value:3.71E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.84|P-value:2.82E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:4.81|P-value:3.37E-7 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.46|P-value:1.76E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.90|P-value:2.80E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.07|P-value:7.57E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.07|P-value:7.66E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.62|P-value:8.90E-7 ID:SGTC_763|Compound:3453-1109|FD-Score:3.49|P-value:1.55E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:13.60|P-value:2.55E-45 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.29|P-value:3.37E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.85|P-value:3.48E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.79|P-value:4.57E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.00|P-value:9.82E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.76|P-value:5.09E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.91|P-value:2.74E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.00|P-value:1.20E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.24|P-value:4.04E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.24|P-value:4.02E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.70|P-value:6.64E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.23|P-value:4.20E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:-3.35|P-value:2.69E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.05|P-value:7.99E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.05|P-value:8.19E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.16|P-value:5.54E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.43|P-value:1.98E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.07|P-value:1.34E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.77|P-value:4.07E-7 ID:SGTC_2292|Compound:7671323|FD-Score:3.02|P-value:9.13E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.87|P-value:3.23E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.71|P-value:6.38E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.23|P-value:4.27E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.81|P-value:4.60E-20 ID:SGTC_2585|Compound:alliin|FD-Score:-3.07|P-value:7.59E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:5.34|P-value:1.73E-8 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.35|P-value:2.71E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.32|P-value:3.08E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.26|P-value:3.84E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.06|P-value:7.96E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.50|P-value:1.52E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-3.42|P-value:2.05E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.58|P-value:1.10E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.84|P-value:3.71E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.84|P-value:2.82E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:4.81|P-value:3.37E-7 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.46|P-value:1.76E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:3.90|P-value:2.80E-5 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.07|P-value:7.57E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.07|P-value:7.66E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.62|P-value:8.90E-7 ID:SGTC_763|Compound:3453-1109|FD-Score:3.49|P-value:1.55E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:13.60|P-value:2.55E-45 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.29|P-value:3.37E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:3.85|P-value:3.48E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.79|P-value:4.57E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:3.00|P-value:9.82E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.76|P-value:5.09E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.91|P-value:2.74E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:5.00|P-value:1.20E-7 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.24|P-value:4.04E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.24|P-value:4.02E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.70|P-value:6.64E-5 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.23|P-value:4.20E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:-3.35|P-value:2.69E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-3.05|P-value:7.99E-4 ID:SGTC_1701|Compound:st028638|FD-Score:3.05|P-value:8.19E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.16|P-value:5.54E-4 ID:SGTC_2024|Compound:5144227|FD-Score:3.43|P-value:1.98E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.07|P-value:1.34E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.77|P-value:4.07E-7 ID:SGTC_2292|Compound:7671323|FD-Score:3.02|P-value:9.13E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.87|P-value:3.23E-5 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.71|P-value:6.38E-5 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.23|P-value:4.27E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.81|P-value:4.60E-20 ID:SGTC_2585|Compound:alliin|FD-Score:-3.07|P-value:7.59E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:5.34|P-value:1.73E-8 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.35|P-value:2.71E-4 ID:SGTC_2806|Compound:7952793|FD-Score:3.32|P-value:3.08E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.26|P-value:3.84E-4 ID:SGTC_3020|Compound:9089140|FD-Score:3.06|P-value:7.96E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.50|P-value:1.52E-4 ID:SGTC_3052|Compound:9092717|FD-Score:-3.42|P-value:2.05E-4 ID:SGTC_3067|Compound:9117431|FD-Score:-3.58|P-value:1.10E-4

Top fitness defect scores for YMR115W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_769 0302-0231 13.60 76.0 µM 2.55E-45 1 1.34E-42
2 SGTC_2582 agaric acid 8.81 100.0 µM 4.60E-20 redox potentiating 86 6.40E-19
3 SGTC_2729 fluphenazine 5.34 10.7 µM 1.73E-8 1 4.64E-8
4 SGTC_1055 3448-0672 5.00 86.0 µM 1.20E-7 15 2.85E-7
5 SGTC_236 1509-0011 4.84 5.3 µM 2.82E-7 333 6.38E-7
6 SGTC_366 0181-0206 4.81 4.3 µM 3.37E-7 Golgi 19 7.53E-7
7 SGTC_2289 7946404 4.77 165.1 µM 4.07E-7 65 9.00E-7
8 SGTC_743 1275-0778 4.62 158.0 µM 8.90E-7 excess fatty acid 23 1.88E-6
9 SGTC_2126 5251174 4.07 33.9 µM 1.34E-5 29 2.40E-5
10 SGTC_2575 plumbagin 4.00 510.0 nM 1.79E-5 superoxide 38 3.15E-5
11 SGTC_908 3448-7491 3.91 47.7 µM 2.74E-5 mitochondrial stress 126 4.69E-5
12 SGTC_464 bw-b 70c 3.90 158.0 µM 2.80E-5 27 4.79E-5
13 SGTC_2489 cantharidin 3.87 73.4 µM 3.23E-5 cell wall signaling 46 5.49E-5
14 SGTC_794 k038-0031 3.85 316.0 µM 3.48E-5 ubiquinone biosynthesis & proteasome 110 5.88E-5
15 SGTC_163 1327-0036 3.84 7.5 µM 3.71E-5 111 6.25E-5
16 SGTC_795 0685-0265 3.79 78.0 µM 4.57E-5 excess fatty acid 32 7.59E-5
17 SGTC_811 0416-0114 3.76 265.0 µM 5.09E-5 31 8.41E-5
18 SGTC_2568 diosmetin 3.71 100.0 µM 6.38E-5 29 1.04E-4
19 SGTC_1353 1498-1206 3.70 8.1 µM 6.64E-5 mitochondrial response to ROS 62 1.08E-4
20 SGTC_3044 9093193 3.50 49.5 µM 1.52E-4 46 2.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.301 2.65E-71 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.265 3.14E-55 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.230 2.05E-41 YCL044C MGR1 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.230 2.27E-41 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.219 1.11E-37 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.214 3.46E-36 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.200 1.39E-31 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.197 1.45E-30 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.196 2.98E-30 YHR013C ARD1 hom Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells; protein abundance increases in response to DNA replication stress
0.193 1.78E-29 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.190 1.51E-28 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.186 1.60E-27 YPR133W-A TOM5 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore
0.185 2.34E-27 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.180 9.37E-26 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.176 8.76E-25 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p