HIPHOP chemogenomics database
YMR117C / SPC24 
Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YMR117C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.110 | 1.48E-10 | YLR406C | RPL31B | hom | Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication |
| 0.108 | 2.95E-10 | YKL049C | CSE4 | het | Centromere protein that resembles histone H3; required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p; Cse4p marks a subset of open chromatin; associated with promoters, accessible chromatin and RNA polymerase II-bound regions |
| 0.103 | 1.87E-9 | YGR103W | NOP7 | het | Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation |
| 0.098 | 1.38E-8 | YHR152W | SPO12 | hom | Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis |
| 0.095 | 3.56E-8 | YKL078W | DHR2 | het | Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis |
| 0.092 | 9.72E-8 | YDR486C | VPS60 | hom | Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p |
| 0.090 | 1.94E-7 | YOR127W | RGA1 | hom | GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.087 | 4.00E-7 | YAL065C_p | YAL065C_p | hom | Putative protein of unknown function; has homology to FLO1; possible pseudogene |
| 0.085 | 7.65E-7 | YOL134C_d | YOL134C_d | het | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit |
| 0.084 | 1.16E-6 | YGR185C | TYS1 | het | Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress |
| 0.084 | 1.19E-6 | YCL043C | PDI1 | het | Protein disulfide isomerase; multifunctional protein of ER lumen, essential for formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; key regulator of Ero1p; forms complex with Mnl1p that has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response; PDI1 has a paralog, EUG1, that arose from the whole genome duplication |
| 0.079 | 4.89E-6 | YNR071C_p | YNR071C_p | hom | Putative aldose 1-epimerase |
| 0.078 | 5.53E-6 | YNR014W_p | YNR014W_p | hom | Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication |
| 0.078 | 5.77E-6 | YNL161W | CBK1 | het | Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress |
| 0.078 | 5.85E-6 | YGL238W | CSE1 | het | Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation |