HIPHOP chemogenomics database
YMR118C_p / SHH3 
Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR118C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.223 | 5.01E-39 | YBR139W | YBR139W | hom | Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner |
| 0.211 | 5.66E-35 | YOR268C_p | YOR268C_p | hom | Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene |
| 0.210 | 1.23E-34 | YBR169C | SSE2 | hom | Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication |
| 0.190 | 1.15E-28 | YNL086W_p | SNN1_p | hom | Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes |
| 0.190 | 1.31E-28 | YGR217W | CCH1 | hom | Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together |
| 0.172 | 1.29E-23 | YKL187C | FAT3 | hom | Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies |
| 0.169 | 9.66E-23 | YJL136W-A_p | YJL136W-A_p | hom | Putative protein of unknown function; identified by SAGE |
| 0.153 | 4.92E-19 | YPL027W | SMA1 | hom | Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p |
| 0.150 | 2.60E-18 | YOR071C | NRT1 | hom | High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity |
| 0.146 | 1.45E-17 | YOR087W | YVC1 | hom | Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock |
| 0.145 | 2.41E-17 | YJL150W_d | YJL150W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.143 | 9.90E-17 | YJR099W | YUH1 | hom | Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p |
| 0.139 | 7.30E-16 | YIL010W | DOT5 | hom | Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth |
| 0.138 | 1.22E-15 | YBR156C | SLI15 | hom | Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly |
| 0.137 | 1.88E-15 | YLR199C | PBA1 | hom | Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly |