YMR118C_p / SHH3

Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR118C / SHH3

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:2.80|P-value:9.84E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:10.40|P-value:7.53E-31 ID:SGTC_338|Compound:4055-0136|FD-Score:4.09|P-value:3.02E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.60|P-value:3.49E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.95|P-value:5.66E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:4.53|P-value:2.77E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:3.54|P-value:4.47E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.35|P-value:1.07E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.14|P-value:2.43E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.09|P-value:3.15E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.51|P-value:5.23E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.09|P-value:3.22E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.28|P-value:1.33E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.17|P-value:2.16E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.81|P-value:9.41E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.87|P-value:7.17E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.07|P-value:3.41E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.09|P-value:2.95E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.13|P-value:2.69E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-7.45|P-value:6.98E-17 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.11|P-value:7.66E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.38|P-value:9.41E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.93|P-value:6.13E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:2.86|P-value:7.80E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.95|P-value:5.59E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.80|P-value:1.35E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.94|P-value:5.90E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.71|P-value:2.09E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.13|P-value:2.69E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.98|P-value:4.92E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.78|P-value:1.43E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.00|P-value:4.64E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.42|P-value:7.79E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.05|P-value:3.55E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.22|P-value:1.84E-4 ID:SGTC_2311|Compound:7694451|FD-Score:2.91|P-value:6.59E-4 ID:SGTC_2322|Compound:7413319|FD-Score:2.80|P-value:9.72E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.21|P-value:1.83E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.24|P-value:1.57E-4 ID:SGTC_2411|Compound:st077133|FD-Score:2.89|P-value:6.93E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.43|P-value:7.41E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.39|P-value:8.99E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.08|P-value:3.10E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.93|P-value:5.71E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.87|P-value:7.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.07|P-value:3.19E-6 ID:SGTC_2585|Compound:alliin|FD-Score:4.14|P-value:2.28E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.92|P-value:6.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.04|P-value:3.92E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.10|P-value:3.08E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-2.88|P-value:7.01E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.18|P-value:2.20E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.97|P-value:5.61E-6 ID:SGTC_57|Compound:miconazole|FD-Score:2.80|P-value:9.84E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:10.40|P-value:7.53E-31 ID:SGTC_338|Compound:4055-0136|FD-Score:4.09|P-value:3.02E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:3.60|P-value:3.49E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:-3.95|P-value:5.66E-6 ID:SGTC_558|Compound:k064-0027|FD-Score:4.53|P-value:2.77E-7 ID:SGTC_561|Compound:1550-0330|FD-Score:3.54|P-value:4.47E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.35|P-value:1.07E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.14|P-value:2.43E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.09|P-value:3.15E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:3.51|P-value:5.23E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:3.09|P-value:3.22E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.28|P-value:1.33E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.17|P-value:2.16E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:2.81|P-value:9.41E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.87|P-value:7.17E-4 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.07|P-value:3.41E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.09|P-value:2.95E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.13|P-value:2.69E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:-7.45|P-value:6.98E-17 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.11|P-value:7.66E-9 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.38|P-value:9.41E-5 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.93|P-value:6.13E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:2.86|P-value:7.80E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:2.95|P-value:5.59E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.80|P-value:1.35E-5 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.94|P-value:5.90E-4 ID:SGTC_1567|Compound:st069303|FD-Score:3.71|P-value:2.09E-5 ID:SGTC_1634|Compound:st006576|FD-Score:3.13|P-value:2.69E-4 ID:SGTC_1795|Compound:st049545|FD-Score:2.98|P-value:4.92E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.78|P-value:1.43E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.00|P-value:4.64E-4 ID:SGTC_2003|Compound:4023581|FD-Score:3.42|P-value:7.79E-5 ID:SGTC_2059|Compound:5238311|FD-Score:-3.05|P-value:3.55E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.22|P-value:1.84E-4 ID:SGTC_2311|Compound:7694451|FD-Score:2.91|P-value:6.59E-4 ID:SGTC_2322|Compound:7413319|FD-Score:2.80|P-value:9.72E-4 ID:SGTC_2352|Compound:9027995|FD-Score:-3.21|P-value:1.83E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-3.24|P-value:1.57E-4 ID:SGTC_2411|Compound:st077133|FD-Score:2.89|P-value:6.93E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.43|P-value:7.41E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.39|P-value:8.99E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.08|P-value:3.10E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-2.93|P-value:5.71E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-2.87|P-value:7.17E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.07|P-value:3.19E-6 ID:SGTC_2585|Compound:alliin|FD-Score:4.14|P-value:2.28E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.11|P-value:2.95E-4 ID:SGTC_2807|Compound:7945238|FD-Score:2.92|P-value:6.25E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.04|P-value:3.92E-4 ID:SGTC_2932|Compound:9016711|FD-Score:3.10|P-value:3.08E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-2.88|P-value:7.01E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.18|P-value:2.20E-4 ID:SGTC_3354|Compound:9151612|FD-Score:3.97|P-value:5.61E-6

Top fitness defect scores for YMR118C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 10.40 35.0 µM 7.53E-31 calcium & mitochondrial duress 8 1.58E-25
2 SGTC_1263 0774-1208 5.11 64.8 µM 7.66E-9 22 1.57E-7
3 SGTC_558 k064-0027 4.53 21.3 µM 2.77E-7 DNA damage response 17 3.00E-6
4 SGTC_2585 alliin 4.14 100.0 µM 2.28E-6 19 1.70E-5
5 SGTC_338 4055-0136 4.09 114.0 µM 3.02E-6 8 2.14E-5
6 SGTC_3354 9151612 3.97 71.4 µM 5.61E-6 8 3.56E-5
7 SGTC_1484 3473-2379 3.80 286.0 µM 1.35E-5 20 7.36E-5
8 SGTC_1924 st058459 3.78 75.1 µM 1.43E-5 14 7.72E-5
9 SGTC_1567 st069303 3.71 68.4 µM 2.09E-5 mitochondrial processes 24 1.05E-4
10 SGTC_400 oxethazaine 3.60 37.5 µM 3.49E-5 calcium & mitochondrial duress 30 1.61E-4
11 SGTC_561 1550-0330 3.54 72.9 µM 4.47E-5 19 1.97E-4
12 SGTC_886 0866-0150 3.51 153.0 µM 5.23E-5 33 2.24E-4
13 SGTC_2415 st077333 3.43 57.7 µM 7.41E-5 74 2.99E-4
14 SGTC_2003 4023581 3.42 200.0 µM 7.79E-5 cell wall signaling 53 3.12E-4
15 SGTC_2435 5706476 3.39 10.6 µM 8.99E-5 38 3.51E-4
16 SGTC_1276 0871-0068 3.38 94.2 µM 9.41E-5 32 3.65E-4
17 SGTC_739 1486-1183 3.35 203.0 µM 1.07E-4 36 4.07E-4
18 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.22 49.5 µM 1.84E-4 52 6.34E-4
19 SGTC_3340 9146634 3.18 11.1 µM 2.20E-4 42 7.37E-4
20 SGTC_1634 st006576 3.13 41.0 µM 2.69E-4 TSC3-RPN4 50 8.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 5.01E-39 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.211 5.66E-35 YOR268C_p YOR268C_p hom Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
0.210 1.23E-34 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.190 1.15E-28 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.190 1.31E-28 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.172 1.29E-23 YKL187C FAT3 hom Protein required for fatty acid uptake; Fat3p abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
0.169 9.66E-23 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.153 4.92E-19 YPL027W SMA1 hom Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p
0.150 2.60E-18 YOR071C NRT1 hom High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
0.146 1.45E-17 YOR087W YVC1 hom Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
0.145 2.41E-17 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.143 9.90E-17 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.139 7.30E-16 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.138 1.22E-15 YBR156C SLI15 hom Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
0.137 1.88E-15 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly