YMR119W / ASI1

Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR119W / ASI1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:3.90|P-value:2.17E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-7.27|P-value:3.94E-12 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.90|P-value:1.73E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.95|P-value:1.87E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.79|P-value:3.22E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.98|P-value:7.52E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.70|P-value:4.41E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.28|P-value:8.30E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.57|P-value:6.73E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.55|P-value:7.12E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.12|P-value:9.92E-5 ID:SGTC_469|Compound:w7|FD-Score:3.55|P-value:7.10E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.26|P-value:8.77E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.76|P-value:8.08E-8 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.79|P-value:7.23E-6 ID:SGTC_512|Compound:prima-1|FD-Score:5.32|P-value:6.91E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:3.65|P-value:5.15E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.64|P-value:5.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:8.10|P-value:6.18E-14 ID:SGTC_700|Compound:3453-2283|FD-Score:9.64|P-value:5.13E-19 ID:SGTC_702|Compound:1488-0190|FD-Score:4.08|P-value:1.16E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:7.85|P-value:3.59E-13 ID:SGTC_818|Compound:4072-2707|FD-Score:3.70|P-value:4.28E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.38|P-value:3.73E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.22|P-value:6.99E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.28|P-value:5.46E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.45|P-value:4.78E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.43|P-value:5.14E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.86|P-value:2.50E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-4.50|P-value:9.73E-6 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.59|P-value:3.04E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.32|P-value:6.90E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.54|P-value:7.24E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.26|P-value:5.91E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.73|P-value:3.90E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.29|P-value:5.26E-5 ID:SGTC_1643|Compound:st009866|FD-Score:-4.19|P-value:3.32E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.06|P-value:8.44E-7 ID:SGTC_1744|Compound:st037937|FD-Score:-3.97|P-value:7.88E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.70|P-value:4.40E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.55|P-value:3.45E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.76|P-value:3.59E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.53|P-value:3.73E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.56|P-value:6.85E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.82|P-value:2.93E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.68|P-value:4.69E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.24|P-value:9.54E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-3.41|P-value:5.53E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.96|P-value:1.77E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-5.72|P-value:3.26E-8 ID:SGTC_3040|Compound:9091894|FD-Score:3.48|P-value:8.75E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.69|P-value:1.07E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-4.39|P-value:1.55E-5 ID:SGTC_3157|Compound:9099274|FD-Score:-3.41|P-value:5.47E-4 ID:SGTC_3259|Compound:9138485|FD-Score:6.29|P-value:5.04E-9 ID:SGTC_17|Compound:0960-0276|FD-Score:3.90|P-value:2.17E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-7.27|P-value:3.94E-12 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.90|P-value:1.73E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:3.95|P-value:1.87E-4 ID:SGTC_125|Compound:0133-0007|FD-Score:3.79|P-value:3.22E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-3.98|P-value:7.52E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:3.70|P-value:4.41E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.28|P-value:8.30E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.57|P-value:6.73E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.55|P-value:7.12E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:4.12|P-value:9.92E-5 ID:SGTC_469|Compound:w7|FD-Score:3.55|P-value:7.10E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.26|P-value:8.77E-7 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:5.76|P-value:8.08E-8 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.79|P-value:7.23E-6 ID:SGTC_512|Compound:prima-1|FD-Score:5.32|P-value:6.91E-7 ID:SGTC_513|Compound:4245-1575|FD-Score:3.65|P-value:5.15E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.64|P-value:5.28E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:8.10|P-value:6.18E-14 ID:SGTC_700|Compound:3453-2283|FD-Score:9.64|P-value:5.13E-19 ID:SGTC_702|Compound:1488-0190|FD-Score:4.08|P-value:1.16E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:7.85|P-value:3.59E-13 ID:SGTC_818|Compound:4072-2707|FD-Score:3.70|P-value:4.28E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.38|P-value:3.73E-5 ID:SGTC_867|Compound:0518-0118|FD-Score:4.22|P-value:6.99E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:4.28|P-value:5.46E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.45|P-value:4.78E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:-3.43|P-value:5.14E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.86|P-value:2.50E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-4.50|P-value:9.73E-6 ID:SGTC_1118|Compound:chelidonine|FD-Score:-3.59|P-value:3.04E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:5.32|P-value:6.90E-7 ID:SGTC_1260|Compound:0700-1617|FD-Score:3.54|P-value:7.24E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.26|P-value:5.91E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.73|P-value:3.90E-4 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:4.29|P-value:5.26E-5 ID:SGTC_1643|Compound:st009866|FD-Score:-4.19|P-value:3.32E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-5.06|P-value:8.44E-7 ID:SGTC_1744|Compound:st037937|FD-Score:-3.97|P-value:7.88E-5 ID:SGTC_1824|Compound:st053723|FD-Score:3.70|P-value:4.40E-4 ID:SGTC_1849|Compound:st056239|FD-Score:-3.55|P-value:3.45E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.76|P-value:3.59E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.53|P-value:3.73E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.56|P-value:6.85E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.82|P-value:2.93E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.68|P-value:4.69E-4 ID:SGTC_2771|Compound:fluoxetine|FD-Score:-3.24|P-value:9.54E-4 ID:SGTC_2860|Compound:9025725|FD-Score:-3.41|P-value:5.53E-4 ID:SGTC_2873|Compound:9040596|FD-Score:3.96|P-value:1.77E-4 ID:SGTC_3018|Compound:9082602|FD-Score:-5.72|P-value:3.26E-8 ID:SGTC_3040|Compound:9091894|FD-Score:3.48|P-value:8.75E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.69|P-value:1.07E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-4.39|P-value:1.55E-5 ID:SGTC_3157|Compound:9099274|FD-Score:-3.41|P-value:5.47E-4 ID:SGTC_3259|Compound:9138485|FD-Score:6.29|P-value:5.04E-9

Top fitness defect scores for YMR119W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_700 3453-2283 9.64 142.0 µM 5.13E-19 amide catabolism 2 2.84E-22
2 SGTC_633 0437-0093 8.10 97.7 µM 6.18E-14 DNA intercalators 1 2.66E-16
3 SGTC_711 k292-0785 7.85 179.0 µM 3.59E-13 DNA intercalators 1 2.10E-15
4 SGTC_3259 9138485 6.29 49.5 µM 5.04E-9 1 1.61E-10
5 SGTC_471 1-acyl-paf 5.76 4.0 µM 8.08E-8 DNA intercalators 8 4.23E-9
6 SGTC_1128 3448-9350 5.32 235.0 µM 6.90E-7 8 5.31E-8
7 SGTC_512 prima-1 5.32 270.0 µM 6.91E-7 DNA intercalators 7 5.32E-8
8 SGTC_470 aa-861 5.26 153.0 µM 8.77E-7 sphingolipid biosynthesis & PDR1 30 7.05E-8
9 SGTC_511 blebbistatin 4.79 171.0 µM 7.23E-6 DNA intercalators 11 8.50E-7
10 SGTC_3099 9120367 4.69 49.5 µM 1.07E-5 6 1.35E-6
11 SGTC_858 0438-0351 4.38 2.8 µM 3.73E-5 copper-dependent oxidative stress 13 5.92E-6
12 SGTC_1533 dihydroergotamine mesylate 4.29 29.4 µM 5.26E-5 DNA intercalators 8 8.87E-6
13 SGTC_911 3456-4043 4.28 236.0 µM 5.46E-5 mitochondrial processes 21 9.27E-6
14 SGTC_1459 k035-0031 4.26 35.7 µM 5.91E-5 DNA intercalators 17 1.02E-5
15 SGTC_867 0518-0118 4.22 155.0 µM 6.99E-5 DNA intercalators 15 1.24E-5
16 SGTC_468 gf-109203x 4.12 121.0 µM 9.92E-5 amide catabolism 5 1.88E-5
17 SGTC_702 1488-0190 4.08 94.0 µM 1.16E-4 amide catabolism 14 2.26E-5
18 SGTC_2873 9040596 3.96 71.4 µM 1.77E-4 47 3.73E-5
19 SGTC_115 0527-0192 3.95 112.0 µM 1.87E-4 69 3.98E-5
20 SGTC_17 0960-0276 3.90 49.8 µM 2.17E-4 33 4.74E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 4.71E-108 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.365 1.72E-105 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.345 6.89E-94 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.327 5.29E-84 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.318 4.29E-79 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.251 6.09E-49 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.242 1.02E-45 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.230 1.94E-41 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.215 2.19E-36 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.208 4.41E-34 YKL139W CTK1 hom Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
0.208 5.71E-34 YGL023C PIB2 hom Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27
0.196 3.79E-30 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.160 1.23E-20 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.129 9.29E-14 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
0.124 7.44E-13 YML093W UTP14 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit