HIPHOP chemogenomics database

YMR119W-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR119W-A / YMR119W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YMR119W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1747	st037496	18.60	66.6 µM	9.32E-79		1	8.90E-78
2	SGTC_548	1436-0017	5.08	110.0 µM	1.58E-7	TSC3-RPN4	21	1.84E-7
3	SGTC_2336	9001819	4.84	198.7 µM	5.59E-7	heme biosynthesis & mitochondrial translocase	24	6.41E-7
4	SGTC_3201	9113999	4.83	49.5 µM	5.87E-7		14	6.73E-7
5	SGTC_619	1652-1634	4.51	108.0 µM	2.86E-6	PDR1	13	3.22E-6
6	SGTC_1133	3473-0247	4.37	50.0 µM	5.49E-6	RSC complex & mRNA processing	34	6.12E-6
7	SGTC_158	k038-0087	4.33	26.4 µM	6.75E-6	ubiquinone biosynthesis & proteasome	118	7.51E-6
8	SGTC_1748	st037455	4.11	53.6 µM	1.82E-5		27	2.00E-5
9	SGTC_471	1-acyl-paf	3.84	4.0 µM	5.57E-5	DNA intercalators	34	6.06E-5
10	SGTC_2710	st078562	3.84	53.7 µM	5.64E-5		18	6.12E-5
11	SGTC_407	eburnamonine	3.84	100.0 µM	5.75E-5		15	6.24E-5
12	SGTC_1220	1838-0075	3.83	193.0 µM	5.96E-5		14	6.47E-5
13	SGTC_1134	3477-0009	3.71	42.5 µM	9.71E-5		51	1.05E-4
14	SGTC_1746	st038117	3.67	42.0 µM	1.14E-4		40	1.23E-4
15	SGTC_151	3013-0144	3.59	2.3 µM	1.56E-4	iron homeostasis	43	1.67E-4
16	SGTC_744	1594-0068	3.45	283.0 µM	2.62E-4	amide catabolism	48	2.80E-4
17	SGTC_2485	5633444	3.44	17.8 µM	2.78E-4	redox potentiating	68	2.96E-4
18	SGTC_365	0121-0052	3.42	13.6 µM	2.95E-4	mitochondrial response to ROS	88	3.14E-4
19	SGTC_1278	0874-0585	3.37	172.0 µM	3.56E-4		31	3.79E-4
20	SGTC_3049	9092223	3.34	49.5 µM	3.89E-4		44	4.13E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.222	2.37E-38	YBL065W_d	YBL065W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.208	9.47E-34	YDR206W	EBS1	hom	Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.174	5.62E-24	YDR171W	HSP42	hom	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.154	3.58E-19	YDL220C	CDC13	het	Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping; autophagy and proteasome are involved in Cdc13p degradation
0.141	2.59E-16	YKL085W	MDH1	hom	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
0.138	1.37E-15	YCR007C_p	YCR007C_p	hom	Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
0.132	2.21E-14	YGR002C	SWC4	het	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex
0.128	1.11E-13	YDR291W	HRQ1	hom	3'-5'DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)
0.124	6.41E-13	YNL047C	SLM2	hom	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.121	2.11E-12	YOR234C	RPL33B	hom	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication
0.118	8.28E-12	YPL228W	CET1	het	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.117	1.15E-11	YFL014W	HSP12	hom	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.116	2.18E-11	YPR177C_d	YPR177C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.115	2.32E-11	YJL010C	NOP9	het	Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain
0.113	7.40E-11	YOR083W	WHI5	hom	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1