HIPHOP chemogenomics database
YMR120C / ADE17 
Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR120C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.240 | 4.20E-45 | YGR204W | ADE3 | hom | Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine |
| 0.182 | 1.74E-26 | YGR061C | ADE6 | hom | Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway |
| 0.148 | 6.03E-18 | YLR058C | SHM2 | hom | Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis |
| 0.140 | 4.82E-16 | YGL234W | ADE5,7 | hom | Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities |
| 0.129 | 7.63E-14 | YMR300C | ADE4 | hom | Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway |
| 0.100 | 7.08E-9 | YLL015W | BPT1 | hom | ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p |
| 0.094 | 4.99E-8 | YKR080W | MTD1 | hom | NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline |
| 0.084 | 1.15E-6 | YOR329C | SCD5 | het | Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency |
| 0.083 | 1.30E-6 | YOL086W-A | MHF1 | hom | Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 |
| 0.082 | 1.90E-6 | YJR046W | TAH11 | het | DNA replication licensing factor, required for pre-replication complex assembly |
| 0.079 | 4.93E-6 | YPL151C | PRP46 | het | Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs |
| 0.078 | 5.77E-6 | YDL236W | PHO13 | hom | Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity |
| 0.078 | 5.92E-6 | YDR408C | ADE8 | hom | Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway |
| 0.075 | 1.30E-5 | YPL160W | CDC60 | het | Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA |
| 0.075 | 1.44E-5 | YLR097C | HRT3 | hom | Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies |