YMR124W_p

Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR124W / YMR124W

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-2.93|P-value:8.79E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:18.30|P-value:1.34E-85 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.19|P-value:1.42E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:4.75|P-value:1.95E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:3.59|P-value:6.08E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.28|P-value:2.28E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.59|P-value:4.64E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:12.70|P-value:1.69E-42 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.69|P-value:3.97E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.09|P-value:4.80E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:10.40|P-value:3.49E-29 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.20|P-value:3.12E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.11|P-value:4.34E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:14.00|P-value:1.05E-50 ID:SGTC_521|Compound:r062-0005|FD-Score:6.06|P-value:4.63E-11 ID:SGTC_586|Compound:0957-0265|FD-Score:3.28|P-value:2.29E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:5.25|P-value:1.01E-8 ID:SGTC_666|Compound:0272-0154|FD-Score:3.50|P-value:9.24E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.41|P-value:1.31E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:30.90|P-value:2.17E-240 ID:SGTC_928|Compound:2764-0428|FD-Score:9.31|P-value:1.22E-23 ID:SGTC_930|Compound:2810-3379|FD-Score:-2.97|P-value:7.58E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.11|P-value:4.37E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:2.96|P-value:7.85E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.00|P-value:6.70E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.98|P-value:7.18E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.92|P-value:1.38E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.50|P-value:9.12E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.38|P-value:1.52E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.99|P-value:9.99E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.27|P-value:2.38E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.68|P-value:4.15E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.38|P-value:1.53E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.07|P-value:5.08E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_1800|Compound:st050079|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.91|P-value:9.15E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.45|P-value:1.14E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.67|P-value:4.41E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.00|P-value:6.67E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.10|P-value:4.62E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.37|P-value:1.55E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.29|P-value:2.26E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.15|P-value:3.72E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.64|P-value:5.01E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.25|P-value:2.73E-6 ID:SGTC_2367|Compound:9070478|FD-Score:9.71|P-value:1.49E-25 ID:SGTC_2398|Compound:5228213|FD-Score:7.44|P-value:9.05E-16 ID:SGTC_2403|Compound:6032726|FD-Score:-3.13|P-value:4.08E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.73|P-value:3.39E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.90|P-value:1.55E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.20|P-value:3.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.24|P-value:2.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:7.92|P-value:1.22E-17 ID:SGTC_2619|Compound:obliquin|FD-Score:12.30|P-value:8.53E-40 ID:SGTC_2781|Compound:5567276|FD-Score:3.58|P-value:6.38E-5 ID:SGTC_2807|Compound:7945238|FD-Score:9.06|P-value:1.66E-22 ID:SGTC_2808|Compound:7946468|FD-Score:3.45|P-value:1.13E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.22|P-value:3.17E-6 ID:SGTC_2852|Compound:9023854|FD-Score:2.93|P-value:8.61E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.07|P-value:5.25E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.30|P-value:2.17E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.82|P-value:2.25E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.52|P-value:8.22E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.75|P-value:3.03E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.39|P-value:1.47E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.12|P-value:5.40E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.81|P-value:2.34E-5 ID:SGTC_3013|Compound:9080133|FD-Score:3.76|P-value:2.92E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.26|P-value:2.44E-4 ID:SGTC_3266|Compound:9136860|FD-Score:8.86|P-value:1.28E-21 ID:SGTC_3311|Compound:9131146|FD-Score:14.80|P-value:6.50E-57 ID:SGTC_3321|Compound:9137793|FD-Score:7.51|P-value:4.85E-16 ID:SGTC_3322|Compound:9139058|FD-Score:3.82|P-value:2.18E-5 ID:SGTC_3331|Compound:9141060|FD-Score:5.83|P-value:2.26E-10 ID:SGTC_3350|Compound:9150499|FD-Score:6.34|P-value:5.98E-12 ID:SGTC_3351|Compound:9150312|FD-Score:5.71|P-value:4.96E-10 ID:SGTC_47|Compound:0149-0135|FD-Score:-2.93|P-value:8.79E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:18.30|P-value:1.34E-85 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.19|P-value:1.42E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:4.75|P-value:1.95E-7 ID:SGTC_76|Compound:0433-0009|FD-Score:3.59|P-value:6.08E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.28|P-value:2.28E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:-4.59|P-value:4.64E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:12.70|P-value:1.69E-42 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.69|P-value:3.97E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:3.09|P-value:4.80E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:10.40|P-value:3.49E-29 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.20|P-value:3.12E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.11|P-value:4.34E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:14.00|P-value:1.05E-50 ID:SGTC_521|Compound:r062-0005|FD-Score:6.06|P-value:4.63E-11 ID:SGTC_586|Compound:0957-0265|FD-Score:3.28|P-value:2.29E-4 ID:SGTC_593|Compound:1203-0218|FD-Score:5.25|P-value:1.01E-8 ID:SGTC_666|Compound:0272-0154|FD-Score:3.50|P-value:9.24E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.41|P-value:1.31E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:30.90|P-value:2.17E-240 ID:SGTC_928|Compound:2764-0428|FD-Score:9.31|P-value:1.22E-23 ID:SGTC_930|Compound:2810-3379|FD-Score:-2.97|P-value:7.58E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.11|P-value:4.37E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:2.96|P-value:7.85E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:-3.00|P-value:6.70E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:2.98|P-value:7.18E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.92|P-value:1.38E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.50|P-value:9.12E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.38|P-value:1.52E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.99|P-value:9.99E-6 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.27|P-value:2.38E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.68|P-value:4.15E-5 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.38|P-value:1.53E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.07|P-value:5.08E-4 ID:SGTC_1754|Compound:st042065|FD-Score:3.12|P-value:4.30E-4 ID:SGTC_1800|Compound:st050079|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_1803|Compound:st050068|FD-Score:2.91|P-value:9.15E-4 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.45|P-value:1.14E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.67|P-value:4.41E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.00|P-value:6.67E-4 ID:SGTC_2133|Compound:5320837|FD-Score:-3.10|P-value:4.62E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.37|P-value:1.55E-4 ID:SGTC_2196|Compound:6573537|FD-Score:4.29|P-value:2.26E-6 ID:SGTC_2257|Compound:7960413|FD-Score:3.15|P-value:3.72E-4 ID:SGTC_2304|Compound:7443016|FD-Score:-3.64|P-value:5.01E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.25|P-value:2.73E-6 ID:SGTC_2367|Compound:9070478|FD-Score:9.71|P-value:1.49E-25 ID:SGTC_2398|Compound:5228213|FD-Score:7.44|P-value:9.05E-16 ID:SGTC_2403|Compound:6032726|FD-Score:-3.13|P-value:4.08E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.73|P-value:3.39E-5 ID:SGTC_2435|Compound:5706476|FD-Score:3.90|P-value:1.55E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-3.20|P-value:3.15E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.24|P-value:2.61E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.43|P-value:1.21E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:7.92|P-value:1.22E-17 ID:SGTC_2619|Compound:obliquin|FD-Score:12.30|P-value:8.53E-40 ID:SGTC_2781|Compound:5567276|FD-Score:3.58|P-value:6.38E-5 ID:SGTC_2807|Compound:7945238|FD-Score:9.06|P-value:1.66E-22 ID:SGTC_2808|Compound:7946468|FD-Score:3.45|P-value:1.13E-4 ID:SGTC_2809|Compound:7964133|FD-Score:4.22|P-value:3.17E-6 ID:SGTC_2852|Compound:9023854|FD-Score:2.93|P-value:8.61E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.07|P-value:5.25E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.30|P-value:2.17E-6 ID:SGTC_2938|Compound:9059746|FD-Score:3.82|P-value:2.25E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.52|P-value:8.22E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.75|P-value:3.03E-5 ID:SGTC_2974|Compound:9094440|FD-Score:-3.39|P-value:1.47E-4 ID:SGTC_2977|Compound:9011197|FD-Score:4.12|P-value:5.40E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.81|P-value:2.34E-5 ID:SGTC_3013|Compound:9080133|FD-Score:3.76|P-value:2.92E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.26|P-value:2.44E-4 ID:SGTC_3266|Compound:9136860|FD-Score:8.86|P-value:1.28E-21 ID:SGTC_3311|Compound:9131146|FD-Score:14.80|P-value:6.50E-57 ID:SGTC_3321|Compound:9137793|FD-Score:7.51|P-value:4.85E-16 ID:SGTC_3322|Compound:9139058|FD-Score:3.82|P-value:2.18E-5 ID:SGTC_3331|Compound:9141060|FD-Score:5.83|P-value:2.26E-10 ID:SGTC_3350|Compound:9150499|FD-Score:6.34|P-value:5.98E-12 ID:SGTC_3351|Compound:9150312|FD-Score:5.71|P-value:4.96E-10

Top fitness defect scores for YMR124W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_916 4466-0038 30.90 42.0 nM 2.17E-240 cell wall 1 1.45E-210
2 SGTC_58 0957-0393 18.30 9.0 µM 1.34E-85 cell wall 17 3.83E-75
3 SGTC_3311 9131146 14.80 2.9 µM 6.50E-57 cell wall 6 4.84E-50
4 SGTC_514 4466-0038 14.00 2.6 nM 1.05E-50 cell wall 11 1.31E-44
5 SGTC_138 0850-0259 12.70 40.9 µM 1.69E-42 cell wall 23 2.00E-37
6 SGTC_2619 obliquin 12.30 87.9 µM 8.53E-40 cell wall 13 4.64E-35
7 SGTC_304 1310-0298 10.40 97.0 µM 3.49E-29 cell wall 1 9.08E-26
8 SGTC_2367 9070478 9.71 135.4 µM 1.49E-25 cell wall 3 1.37E-22
9 SGTC_928 2764-0428 9.31 58.7 µM 1.22E-23 cell wall 4 6.48E-21
10 SGTC_2807 7945238 9.06 52.0 µM 1.66E-22 1 6.38E-20
11 SGTC_3266 9136860 8.86 49.5 µM 1.28E-21 cell wall 11 3.83E-19
12 SGTC_2584 androsterone 7.92 48.7 µM 1.22E-17 cell wall 27 1.17E-15
13 SGTC_3321 9137793 7.51 26.8 µM 4.85E-16 cell wall 13 2.95E-14
14 SGTC_2398 5228213 7.44 48.8 µM 9.05E-16 iron homeostasis 2 5.10E-14
15 SGTC_3350 9150499 6.34 3.6 µM 5.98E-12 cell wall 12 1.14E-10
16 SGTC_521 r062-0005 6.06 13.8 µM 4.63E-11 3 6.87E-10
17 SGTC_3331 9141060 5.83 2.0 µM 2.26E-10 cell wall 12 2.76E-9
18 SGTC_3351 9150312 5.71 21.6 µM 4.96E-10 cell wall 10 5.50E-9
19 SGTC_593 1203-0218 5.25 61.7 µM 1.01E-8 2 7.74E-8
20 SGTC_69 0096-0274 4.75 206.7 µM 1.95E-7 mitochondrial processes 22 1.04E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.534 7.11E-247 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.522 2.27E-233 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.496 9.11E-208 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.486 1.92E-198 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.478 2.04E-191 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.456 9.74E-172 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.454 3.04E-170 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.443 5.34E-161 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.422 7.13E-145 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.413 1.80E-138 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.398 8.52E-128 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.395 6.71E-126 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.394 1.53E-124 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.381 5.85E-116 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.376 4.86E-113 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication