YMR126C_p / DLT1

Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR126C / DLT1

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:6.99|P-value:6.33E-15 ID:SGTC_18|Compound:0111-0177|FD-Score:2.88|P-value:7.68E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:2.89|P-value:7.40E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:6.62|P-value:1.45E-13 ID:SGTC_59|Compound:0330-0160|FD-Score:3.93|P-value:7.49E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:5.40|P-value:1.36E-9 ID:SGTC_129|Compound:0088-0017|FD-Score:3.44|P-value:7.40E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.50|P-value:5.64E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.43|P-value:8.02E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.16|P-value:2.47E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.82|P-value:9.42E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.60|P-value:3.67E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:3.46|P-value:6.77E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:15.30|P-value:3.05E-64 ID:SGTC_599|Compound:1935-0052|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.43|P-value:7.95E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.72|P-value:9.84E-8 ID:SGTC_616|Compound:4092-0450|FD-Score:4.77|P-value:7.33E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:6.08|P-value:1.04E-11 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.45|P-value:6.89E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:7.44|P-value:1.17E-16 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.55|P-value:4.39E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:2.82|P-value:9.44E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.66|P-value:2.82E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.00|P-value:4.85E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.06|P-value:3.72E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.65|P-value:2.95E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.09|P-value:3.39E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-2.92|P-value:6.36E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.02|P-value:4.19E-4 ID:SGTC_1750|Compound:st081859|FD-Score:39.40|P-value:0 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.44|P-value:1.16E-16 ID:SGTC_2256|Compound:7954252|FD-Score:-3.89|P-value:8.89E-6 ID:SGTC_2279|Compound:7948423|FD-Score:3.08|P-value:3.44E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.10|P-value:3.18E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.46|P-value:6.52E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.65|P-value:2.81E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-3.60|P-value:3.53E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.30|P-value:1.38E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.18|P-value:2.25E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.82|P-value:1.24E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.91|P-value:8.32E-6 ID:SGTC_2480|Compound:5767542|FD-Score:2.87|P-value:7.79E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.01|P-value:4.47E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.38|P-value:6.66E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.89|P-value:7.05E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.44|P-value:7.65E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-2.90|P-value:6.66E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.86|P-value:8.31E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.15|P-value:6.31E-12 ID:SGTC_8|Compound:0354-0001|FD-Score:6.99|P-value:6.33E-15 ID:SGTC_18|Compound:0111-0177|FD-Score:2.88|P-value:7.68E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:2.89|P-value:7.40E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:6.62|P-value:1.45E-13 ID:SGTC_59|Compound:0330-0160|FD-Score:3.93|P-value:7.49E-6 ID:SGTC_87|Compound:0100-0052|FD-Score:5.40|P-value:1.36E-9 ID:SGTC_129|Compound:0088-0017|FD-Score:3.44|P-value:7.40E-5 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.50|P-value:5.64E-5 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.43|P-value:8.02E-5 ID:SGTC_252|Compound:miconazole|FD-Score:3.16|P-value:2.47E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:2.82|P-value:9.42E-4 ID:SGTC_542|Compound:3381-0244|FD-Score:3.60|P-value:3.67E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:3.46|P-value:6.77E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:15.30|P-value:3.05E-64 ID:SGTC_599|Compound:1935-0052|FD-Score:3.13|P-value:2.86E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.43|P-value:7.95E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:4.72|P-value:9.84E-8 ID:SGTC_616|Compound:4092-0450|FD-Score:4.77|P-value:7.33E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:6.08|P-value:1.04E-11 ID:SGTC_649|Compound:1123-0311|FD-Score:-3.45|P-value:6.89E-5 ID:SGTC_696|Compound:1560-0013|FD-Score:7.44|P-value:1.17E-16 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.55|P-value:4.39E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.06|P-value:3.70E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:2.82|P-value:9.44E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.66|P-value:2.82E-5 ID:SGTC_1333|Compound:1482-0047|FD-Score:2.92|P-value:6.50E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.00|P-value:4.85E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.06|P-value:3.72E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.65|P-value:2.95E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.09|P-value:3.39E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-2.92|P-value:6.36E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.02|P-value:4.19E-4 ID:SGTC_1750|Compound:st081859|FD-Score:39.40|P-value:0 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.44|P-value:1.16E-16 ID:SGTC_2256|Compound:7954252|FD-Score:-3.89|P-value:8.89E-6 ID:SGTC_2279|Compound:7948423|FD-Score:3.08|P-value:3.44E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.10|P-value:3.18E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.46|P-value:6.52E-5 ID:SGTC_2451|Compound:5856223|FD-Score:-3.65|P-value:2.81E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-3.60|P-value:3.53E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.30|P-value:1.38E-4 ID:SGTC_2456|Compound:5770359|FD-Score:-3.18|P-value:2.25E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-3.82|P-value:1.24E-5 ID:SGTC_2463|Compound:5473429|FD-Score:3.91|P-value:8.32E-6 ID:SGTC_2480|Compound:5767542|FD-Score:2.87|P-value:7.79E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:-3.01|P-value:4.47E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.38|P-value:6.66E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:-2.89|P-value:7.05E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.44|P-value:7.65E-5 ID:SGTC_2830|Compound:7992007|FD-Score:-2.90|P-value:6.66E-4 ID:SGTC_3018|Compound:9082602|FD-Score:2.86|P-value:8.31E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.15|P-value:6.31E-12

Top fitness defect scores for YMR126C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 39.40 2.4 µM 0 endomembrane recycling 3 0
2 SGTC_568 1193-0097 15.30 7.5 µM 3.05E-64 ERAD & cell cycle 2 3.24E-53
3 SGTC_2250 alverine citrate 7.44 130.0 µM 1.16E-16 27 4.92E-14
4 SGTC_696 1560-0013 7.44 611.0 µM 1.17E-16 1 4.94E-14
5 SGTC_8 0354-0001 6.99 70.0 µM 6.33E-15 19 1.34E-12
6 SGTC_56 0957-0365 6.62 83.2 µM 1.45E-13 Golgi 14 1.77E-11
7 SGTC_3152 9099253 6.15 49.5 µM 6.31E-12 NEO1-PIK1 55 3.99E-10
8 SGTC_637 1181-0519 6.08 7.3 µM 1.04E-11 fatty acid desaturase (OLE1) 51 6.03E-10
9 SGTC_87 0100-0052 5.40 35.5 µM 1.36E-9 44 3.38E-8
10 SGTC_616 4092-0450 4.77 108.0 µM 7.33E-8 2 9.18E-7
11 SGTC_611 3453-1652 4.72 23.7 µM 9.84E-8 10 1.17E-6
12 SGTC_59 0330-0160 3.93 1.3 µM 7.49E-6 114 4.26E-5
13 SGTC_2463 5473429 3.91 200.0 µM 8.32E-6 ERG2 16 4.65E-5
14 SGTC_1161 k007-0610 3.66 110.0 µM 2.82E-5 ERAD & cell cycle 135 1.28E-4
15 SGTC_1474 0330-0125 3.65 5.3 µM 2.95E-5 39 1.33E-4
16 SGTC_542 3381-0244 3.60 89.3 µM 3.67E-5 54 1.59E-4
17 SGTC_562 3772-2733 3.46 112.0 µM 6.77E-5 ERG2 103 2.65E-4
18 SGTC_129 0088-0017 3.44 176.6 µM 7.40E-5 85 2.86E-4
19 SGTC_2815 7968870 3.44 71.4 µM 7.65E-5 46 2.94E-4
20 SGTC_605 1315-0399 3.43 119.0 µM 7.95E-5 Golgi 41 3.03E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.721 0 YPR153W YPR153W hom Putative protein of unknown function
0.561 2.31E-277 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.558 4.12E-274 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.552 1.86E-266 YBR255W MTC4 hom Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1
0.528 1.55E-240 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.455 5.29E-171 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.429 4.66E-150 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.345 1.07E-94 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.341 6.74E-92 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.320 1.15E-80 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.314 8.96E-78 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.308 1.26E-74 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.304 1.17E-72 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.303 4.75E-72 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.298 8.54E-70 YHR151C MTC6 hom Protein of unknown function; mtc6 is synthetically sick with cdc13-1