YMR129W / POM152

Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR129W / POM152

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:2.87|P-value:3.06E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.79|P-value:4.23E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-2.87|P-value:5.23E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.98|P-value:2.35E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.35|P-value:5.91E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:2.78|P-value:4.39E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.37|P-value:5.54E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.53|P-value:1.34E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.01|P-value:2.81E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.30|P-value:7.79E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.18|P-value:7.25E-7 ID:SGTC_1115|Compound:galangin|FD-Score:2.61|P-value:8.88E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.59|P-value:9.79E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-2.76|P-value:8.11E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.75|P-value:8.45E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.22|P-value:6.26E-5 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.62|P-value:2.21E-8 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.03|P-value:1.51E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.59|P-value:9.74E-4 ID:SGTC_1794|Compound:st048918|FD-Score:2.91|P-value:2.61E-4 ID:SGTC_1903|Compound:st060211|FD-Score:9.46|P-value:4.51E-29 ID:SGTC_2017|Compound:5132927|FD-Score:-2.92|P-value:4.08E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.13|P-value:9.31E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.00|P-value:1.70E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.56|P-value:2.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.23|P-value:5.98E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.87|P-value:5.16E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.03|P-value:2.62E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.55|P-value:1.19E-5 ID:SGTC_2702|Compound:st077768|FD-Score:-2.77|P-value:7.82E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.55|P-value:1.23E-5 ID:SGTC_2716|Compound:st080858|FD-Score:2.73|P-value:5.39E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.32|P-value:6.96E-5 ID:SGTC_3152|Compound:9099253|FD-Score:2.98|P-value:1.89E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.15|P-value:4.18E-7 ID:SGTC_6|Compound:0844-0013|FD-Score:2.87|P-value:3.06E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.79|P-value:4.23E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:-2.87|P-value:5.23E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:-3.98|P-value:2.35E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.35|P-value:5.91E-5 ID:SGTC_634|Compound:1611-4317|FD-Score:2.78|P-value:4.39E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.37|P-value:5.54E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.53|P-value:1.34E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.01|P-value:2.81E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-3.30|P-value:7.79E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.18|P-value:7.25E-7 ID:SGTC_1115|Compound:galangin|FD-Score:2.61|P-value:8.88E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:2.59|P-value:9.79E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-2.76|P-value:8.11E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-2.75|P-value:8.45E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.22|P-value:6.26E-5 ID:SGTC_1343|Compound:1487-0095|FD-Score:4.62|P-value:2.21E-8 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.03|P-value:1.51E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:2.59|P-value:9.74E-4 ID:SGTC_1794|Compound:st048918|FD-Score:2.91|P-value:2.61E-4 ID:SGTC_1903|Compound:st060211|FD-Score:9.46|P-value:4.51E-29 ID:SGTC_2017|Compound:5132927|FD-Score:-2.92|P-value:4.08E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.13|P-value:9.31E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.00|P-value:1.70E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.56|P-value:2.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.23|P-value:5.98E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:-2.87|P-value:5.16E-4 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:-3.03|P-value:2.62E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.55|P-value:1.19E-5 ID:SGTC_2702|Compound:st077768|FD-Score:-2.77|P-value:7.82E-4 ID:SGTC_2703|Compound:st077852|FD-Score:3.55|P-value:1.23E-5 ID:SGTC_2716|Compound:st080858|FD-Score:2.73|P-value:5.39E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.32|P-value:6.96E-5 ID:SGTC_3152|Compound:9099253|FD-Score:2.98|P-value:1.89E-4 ID:SGTC_3328|Compound:9140624|FD-Score:4.15|P-value:4.18E-7

Top fitness defect scores for YMR129W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1903 st060211 9.46 78.3 µM 4.51E-29 1 1.60E-21
2 SGTC_1343 1487-0095 4.62 224.0 µM 2.21E-8 4 1.93E-6
3 SGTC_3328 9140624 4.15 29.0 µM 4.18E-7 15 1.65E-5
4 SGTC_2678 equilin 3.55 100.0 µM 1.19E-5 31 1.91E-4
5 SGTC_2703 st077852 3.55 53.4 µM 1.23E-5 35 1.95E-4
6 SGTC_766 1391-0721 3.53 126.0 µM 1.34E-5 28 2.09E-4
7 SGTC_2651 1327-0036 3.23 5.0 µM 5.98E-5 221 6.24E-4
8 SGTC_1261 0712-0010 3.22 12.7 µM 6.26E-5 RNA processing & uracil transport 54 6.45E-4
9 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.13 3.7 µM 9.31E-5 177 8.62E-4
10 SGTC_1346 1488-2224 3.03 62.4 µM 1.51E-4 50 0.00123
11 SGTC_2588 indole-3-carbinol 3.00 100.0 µM 1.70E-4 107 0.00134
12 SGTC_3152 9099253 2.98 49.5 µM 1.89E-4 NEO1-PIK1 213 0.00145
13 SGTC_1794 st048918 2.91 76.9 µM 2.61E-4 38 0.00184
14 SGTC_6 0844-0013 2.87 19.8 µM 3.06E-4 233 0.00206
15 SGTC_65 0798-0905 2.79 35.0 µM 4.23E-4 calcium & mitochondrial duress 183 0.00262
16 SGTC_634 1611-4317 2.78 11.2 µM 4.39E-4 ERG2 76 0.00269
17 SGTC_2716 st080858 2.73 38.6 µM 5.39E-4 60S ribosome export 71 0.00313
18 SGTC_1115 galangin 2.61 695.7 nM 8.88E-4 RPP1 & pyrimidine depletion 96 0.00451
19 SGTC_1508 1080-0625 2.59 72.9 µM 9.74E-4 74 0.00483
20 SGTC_1123 mangostin 2.59 811.3 nM 9.79E-4 mitochondrial response to ROS 126 0.00485

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.232 4.11E-42 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.202 4.42E-32 YLR241W_p YLR241W_p hom Putative protein of unknown function, may be involved in detoxification
0.172 1.26E-23 YMR025W CSI1 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome
0.155 1.84E-19 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.146 1.76E-17 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.142 1.21E-16 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.137 1.69E-15 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.130 4.32E-14 YDR508C GNP1 hom High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication
0.129 7.96E-14 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.128 1.02E-13 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.127 1.79E-13 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.127 1.93E-13 YDR402C DIT2 hom N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s
0.123 7.09E-13 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.122 1.23E-12 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.120 3.69E-12 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria